Zinaprim 1 kg

DESCRIPTION

Zinaprim is an antibacterial drug containing sulfamethazine and trimethoprim as active ingredients. The drug in appearance is a fine white-yellow powder.

COMPOSITION

1 g of the drug contains 200 mg of sulfamethazine and 40 mg of trimethoprim.

PHARMACHOLOGIC EFFECT

Sulfamethazine and trimethoprim, which are part of the drug, separately act on the microbial cell bacteriostatically. When used together, a synergistic effect and a bactericidal effect are manifested, which are due to the sequential blockade of enzymes in the microbial cell: sulfamethazine disrupts the synthesis of dihydrofolic acid, and trimethoprim blocks the next stage of bacterial metabolism - the restoration of dihydrofolic acid to tetrahydrofolic acid, which is necessary for the development of microorganisms. The drug has a wide spectrum of action against gram-negative and gram-positive microorganisms, including Clostridium spp., E. Coli, Salmonella spp., Haemophilus spp., Pasteurella spp., Proteus mirabilis, Streptococcus spp. The antibacterial components of zinaprim are well absorbed from the gastrointestinal tract and are quickly distributed to all organs and tissues of the body. Sulfamethozin and trimethoprim are excreted mainly in the urine and, to a lesser extent, in the bile.

INDICATIONS

Treatment of bacterial diseases of cattle, sheep, goats, pigs, horses, dogs, cats, rabbits and poultry, localized in the gastrointestinal tract, respiratory tract, genitourinary system, caused by microorganisms sensitive to the combination of trimethoprim-sulfanilamide.

DOSAGE AND APPLICATIONS

The drug is administered orally once a day: to cattle, sheep, goats and small animals at a dose of 1 g per 10 kg of body weight for 3 to 5 days. It is possible to use zinaprim with water at the rate of 750 g per 1000 liters of drinking water. On the first day, it is recommended to enter a therapeutic dose twice with an interval of 12 hours. Zinaprim is applied to poultry and rabbits in a dose of 1 g per liter of drinking water on the first day, in the next 2 - 3 days the daily dose is 0.5 g per 1 liter of drinking water. During the treatment period, the bird receives only water containing zinaprim.

SIDE EFFECTS

Not observed in recommended doses. With an increase in the duration of use, vomiting, diarrhea, crystalluria may appear.

CONTRAINDICATIONS

Individual hypersensitivity to one of the components of the drug. It should be administered with caution to animals with renal and hepatic insufficiency.

SPECIAL INSTRUCTIONS

Slaughter for meat is allowed 5 days after the last use of the drug. The meat of animals that were forcedly killed before the expiration of the specified period can be used to feed fur-bearing animals or for the production of meat and bone meal. It is forbidden to use for food purposes milk obtained from animals during the period of treatment with the drug and within 4 days after stopping the use of the drug.

SHELF LIFE AND STORAGE

List B. In a dry, dark place at a temperature of 5 to 25 В° C. The shelf life is 5 years.

PACKAGING

Produced in foil packs of 1 kg.

Specifications

KolVUP

12

Manufacturer

Livisto

Temperature regime

from +5 to +25

Teaser

treatment of bacterial diseases of cattle, sheep, goats, pigs, horses, dogs, cats, rabbits and poultry caused by microorganisms sensitive to the trimethoprim-sulfonamide combination