xylometazoline | Tizin Classic nasal spray 0, 1% 10 ml

Special Price $14.55 Regular Price $23.00
In stock
SKU
BID695131
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Release form

Dosage nasal spray 0.1%.
Release form

Dosage nasal spray 0.1%.

Packaging

10 ml of the drug in a bottle, for 0.1% at least 70 doses.

Pharmacological action

Xylometazoline (an imidazole derivative) is a sympathomimetic drug with alpha-adrenergic activity. It has a vasoconstrictor effect and reduces swelling of the mucous membrane.

Action usually begins within 5–10 minutes.

The drug facilitates nasal breathing by reducing swelling and hyperemia of the mucous membrane, and also improves discharge discharge.

Indications

To reduce swelling of the mucous membrane of the nasopharynx and secretions in acute allergic rhinitis, acute respiratory infections with rhinitis, sinusitis, hay fever, otitis media.

Preparing the patient for diagnostic procedures in the nasal passages.

Contraindications

Hypersensitivity to any component of the drug, concomitant use of monoamine oxidase inhibitors (MAOs) or other drugs that can cause high blood pressure, hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, cerebral surgery , children's age (up to 6 years - for a dosage of 0.1%, up to 2 years - for a dosage of 0.05%).

Precautions - IHD (angina pectoris), prostatic hyperplasia, thyrotoxicosis, diabetes mellitus, pheochromocytoma, in patients with hypersensitivity to adrenergic agonists, accompanied by symptoms of insomnia, dizziness.

Use during pregnancy and lactation

Pregnancy

Carefully controlled and relevant studies have not been conducted in pregnant women. The drug should not be used during pregnancy unless the potential benefit of treating the mother outweighs the potential risk to the developing fetus.

Lactation

It is not known whether xylometazoline or its metabolites passes into breast milk, so the drug should not be used during breast-feeding.

Special instructions

Long-term use and overdose of sympathomimetics that have a decongestant effect can lead to reactive hyperemia of the nasal mucosa.

The recoil phenomenon can cause airway obstruction, which leads to the fact that the patient begins to use the drug repeatedly or even constantly. This can lead to chronic swelling (drug rhinitis), and as a result, even to atrophy of the nasal mucosa (ozena).

In case of chronic rhinitis, TizinВ® Classic 0.05% and 0.1% can only be used under medical supervision, given the risk of atrophy of the nasal mucosa.

TizinВ® Classic should not be used if hypersensitivity to benzalkonium chloride, which is part of the drug as a preservative.

Do not exceed recommended doses, especially in children and the elderly.

INFLUENCE ON THE ABILITY TO DRIVE A CAR AND USE THE MACHINE

With prolonged treatment or the use of TizinВ® Classic in higher doses, it is impossible to exclude the possibility of its systemic effect on the cardiovascular system, which may impair the ability to drive and use the equipment.

Composition of

In 1 ml of solution contains:

active ingredient:

xylometazoline hydrochloride 1.0 mg (0.1%)

amount of active ingredient in a single dose for 0.1% - 0, 14 mg xylometazoline hydrochloride

excipients:

benzalkonium chloride - 0.2 mg

sorbitol 70% - 20.0 mg

sodium chloride - 4.16 mg

sodium dihydrogen phosphate dihydrate - 3.38 mg

disodium hydrogen phosphate dihydrate 2.0 mg

disodium edetate - 1.0 mg

purified water - a sufficient amount.

Dosage and administration of

Adults and children of school age (over 6 years old)

are administered 3 times a day with one dose of Tizin® Classic in the form of 0.1% nasal spray dosed into each nostril. The dose depends on the individual sensitivity of the patient and the clinical effect. Xylometazoline in the form of a nasal dosage spray should not be used for more than 5-7 days, unless the doctor has recommended a different duration of treatment.

After completion of therapy, the drug can be prescribed again only after a few days.

Always consult a doctor regarding the duration of use in children.

Side effects

-Tizin® Classic may cause transient mild nose irritation (burning), paresthesia, sneezing, and hypersecretion in susceptible people.

- In some cases, after the use of the drug, increased swelling of the nasal mucosa (reactive hyperemia) may be observed.

- Prolonged or frequent use of xylometazoline or its use in high doses can lead to a burning sensation in the nose or dry mucous membrane, as well as reactive stasis with the development of drug rhinitis. This effect can be observed even 5-7 days after completion of treatment, and with prolonged use can cause irreversible damage to the mucous membrane with the formation of crusts (dry rhinitis).

- In very rare cases, headache, insomnia or fatigue, depression (with prolonged use in high doses) may occur. In isolated cases, local intranasal use of sympathomimetics may be accompanied by systemic effects, such as palpitations, tachycardia, arrhythmias, increased blood pressure, and visual impairment.

Drug Interactions

The simultaneous use of MAO inhibitors such as tranylcypromine or tricyclic antidepressants can lead to high blood pressure due to the cardiovascular effects of these substances.

overdose

intoxication symptoms

An overdose or accidental intake of the drug can lead to the following symptoms: pupillary enlargement, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmias mental disorders. In addition, the following symptoms can be observed: central nervous system suppression, accompanied by drowsiness, decreased body temperature, bradycardia, shock-like hypotension, apnea and coma.

Treatment of intoxication

Use of activated carbon, gastric lavage, artificial respiration with oxygen administration. To reduce blood pressure, phentolamine is used 5 mg saline intravenously slowly or 100 mg orally.

Vasopressor agents are contraindicated. If necessary, use antipyretic and anticonvulsants.

Storage Conditions

Do not store above 25 РC. Keep out of reach of children.

Shelf life

3 years.

Deystvuyushtee substance

Xylometazoline

Terms and conditions

without prescription

Dosage form

spray nasal

Possible product names

Tizin Classic Nasal Spray 0.1% 10 ml

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