Vinpotropil capsules 5mg + 400mg, No. 60

• insufficiency of cerebral circulation (the recovery period of ischemic and hemorrhagic stroke, encephalopathy of various origins);

• parkinsonism of vascular origin;

• intoxication;

• brain trauma and other diseases of the central nervous system, accompanied by a decrease in intellectual and mnestic functions;

• psychoorganic syndrome with a predominance of signs of asthenia and adynamia;

• asthenic syndrome;

• labyrinthopathies, Meniere's syndrome;

• prevention of migraine;

For adults and adolescents over 14 years of age, the drug is prescribed 1-2 capsules 3 times / day. Maintenance dose - 1 capsule 3 times / day.

The duration of the course of treatment is from 2-3 weeks to 2-6 months.

Capsules should be taken without chewing, before meals, with plenty of water.

Active ingredients:

vinpocetine - 5 mg

piracetam - 400 mg

Excipients: lactose, calcium stearate.

• severe heart rhythm disturbances;

• Ischemic heart disease (severe course);

• acute stage of hemorrhagic stroke;

• renal failure;

• liver failure;

• children up to age 14;

• pregnancy;

• lactation (breastfeeding);

• hypersensitivity to the components of the drug.

Clinical and pharmacological group: Nootropic drug

Pharmaco-therapeutic group: Cerebral blood flow improving agent + nootropic agent

pharmachologic effect

Combined nootropic drug also has vasodilating properties. Improves cerebral circulation, causes a slight decrease in systemic blood pressure. Increases the resistance of brain cells to hypoxia, facilitates the transport of oxygen and substrates of energy supply to tissues (due to a decrease in the affinity of erythrocytes for oxygen, increased absorption and metabolism of glucose and the transition to aerobic processes). Promotes the accumulation of cAMP and ATP in the tissues, increasing the content of catecholamines in the brain tissues. The vasodilating effect is associated with a direct relaxing effect on the smooth muscles of the vessels, predominantly of the brain. The drug does not cause the stealing phenomenon and enhances the blood supply to the ischemic area of ??the brain, without affecting the blood supply to intact areas.Improves microcirculation in the brain by reducing platelet aggregation, reducing blood viscosity, increasing erythrocyte deformability.

It has a positive effect on metabolic processes in brain cells, increases the concentration of ATP in brain tissue, enhances the synthesis of ribonucleic acid and phospholipids, as well as glucose utilization. It improves the integrative activity of the brain, promotes the consolidation of memory, facilitates the learning process, and changes the rate of propagation of excitation in the brain. It enhances alpha and beta activity, reduces delta activity on the EEG, reduces the severity of vestibular nystagmus, improves connections between the hemispheres and synaptic conduction in neocortical structures, increases mental activity, enhances cerebral blood flow, does not have a sedative, psychostimulating effect.

The action of the drug develops gradually.

Pharmacokinetics

Vinpocetine

After taking the drug inside, vinpocetine is well absorbed from the gastrointestinal tract, bioavailability is about 50-70%. Cmax is reached within 1 hour after administration. Therapeutic plasma concentration varies from 10 to 20 ng / ml. T1 / 2 - 4.8 h.

Piracetam

After taking the drug inside, it is well absorbed from the gastrointestinal tract, bioavailability is about 95%. Cmax is achieved within 0.5-1 hours after oral administration. Penetrates the BBB, accumulates in the brain tissues 1-4 hours after ingestion. It is excreted from the cerebrospinal fluid much more slowly than from other tissues and body fluids. Virtually no biotransformation in the body and 2/3 is excreted by the kidneys unchanged within 30 hours.T1 / 2 from plasma is 4.5 hours, from the brain - 7.7 hours

Indications for VinpotropilЃ

• insufficiency of cerebral circulation (the recovery period of ischemic and hemorrhagic stroke, encephalopathy of various origins);

• parkinsonism of vascular origin;

• intoxication;

• brain trauma and other diseases of the central nervous system, accompanied by a decrease in intellectual and mnestic functions;

• psychoorganic syndrome with a predominance of signs of asthenia and adynamia;

• asthenic syndrome;

• labyrinthopathies, Meniere's syndrome;

• prevention of migraine;

• prevention of kinetosis.

Dosage regimen

For adults and adolescents over 14 years of age, the drug is prescribed 1-2 capsules 3 times / day. Maintenance dose - 1 capsule 3 times / day.

The duration of the course of treatment is from 2-3 weeks to 2-6 months.

Capsules should be taken without chewing, before meals, with plenty of water.

Side effect

From the side of the central nervous system: mental and motor agitation, irritability, imbalance, decreased ability to concentrate, anxiety, sleep disturbances, dizziness, headache, extrapyramidal disorders.

From the digestive system: gastralgia, nausea, vomiting, constipation, diarrhea, loss of appetite.

From the side of the cardiovascular system: worsening of angina pectoris, tachycardia, extrasystole, slowing of AV conduction.

Others: increased sexual activity.

The drug is well tolerated. Side effects are rare.

Contraindications for use

• severe heart rhythm disturbances;

• Ischemic heart disease (severe course);

• acute stage of hemorrhagic stroke;

• renal failure;

• liver failure;

• children up to age 14;

• pregnancy;

• lactation (breastfeeding);

• hypersensitivity to the components of the drug.

Application during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

Application for violations of liver function

The drug is contraindicated in liver failure.

Application for impaired renal function

The drug is contraindicated in renal failure.

Application in children

The drug is contraindicated in children under 14 years of age.

special instructions

Before discontinuing the drug, the dose of Vinpotropil should be reduced gradually.

Overdose

Data on an overdose of Vinpotropil were not provided.

Drug interactions

When used together, Vinpotropil increases the risk of hemorrhagic complications of heparin therapy, enhances the effects of thyroid hormones, antipsychotics (neuroleptics), indirect anticoagulants.

With the simultaneous use of Vinpotropil weakens the effect of anticonvulsants (reduces the seizure threshold).

Storage conditions

List B. The drug should be stored in a dry, dark place and out of reach of children at a temperature not exceeding 25 ? C.

Shelf life

Shelf life is 2 years.

Terms of sale

The drug is available with a prescription.

Contacts for inquiries

KANONFARMA PRODUCTION CJSC (Russia)