Vibrocil drops, 15ml

acute rhinitis (including runny nose for colds);

allergic rhinitis (including hay fever);

vasomotor rhinitis;

chronic rhinitis;

acute and chronic sinusitis;

acute otitis media (as an auxiliary method of treatment);

preparation for surgical interventions in the nasal area and elimination of edema of the nasal mucosa and paranasal sinuses after surgical interventions in this area.

Intranasally, before administration, the nasal passages should be cleaned.

Nasal drops. Adults and children over 6 years old - 3-4 drops in each nasal passage 3-4 times a day. Children from 1 year to 6 years old - only in the form of nasal drops, 1-2 drops in each nasal passage 3-4 times a day: from 1 year to 6 years - 1-2 drops, up to 1 year - 1 drop in each nasal passage 3-4 times a day. Buried intranasally, with the head thrown back. This head position is maintained for several minutes.

Nasal spray. Adults and children over 6 years of age are prescribed 1-2 sprays in each nasal passage 3-4 times a day. When using a spray, the spray should be held vertically, tip up. Keeping the head straight, insert the tip into the nasal passage, squeeze the nebulizer once with a short sharp movement, and remove the tip from the nose, unclench it. It is recommended to inhale slightly through the nose while spraying.

Nasal gel. For adults and children over 6 years of age, the gel is applied into each nasal passage as deep as possible 3-4 times a day (the last application is carried out shortly before bedtime). The use of the drug immediately before bedtime provides an effect throughout the night.

Per 1 ml:
Active substances: phenylephrine 2.5 mg, dimethindene maleate 0.25 mg.
Excipients: benzalkonium chloride 50% solution (in terms of benzalkonium chloride) - 0.2 mg (0.1 mg), citric acid monohydrate - 2.6 mg, sodium hydrogen phosphate - 4.4 mg, sorbitol - 35 mg, lavender oil - 0.2 mg, water - up to 1 ml

hypersensitivity to phenylephrine, dimethindene maleate or other components of the drug; atrophic rhinitis (including with fetid discharge - ozena); simultaneous administration of MAO inhibitors and a period up to 14 days after their cancellation; angle-closure glaucoma; children's age up to 1 year.

— осторожностью следует примен¤ть препарат при сердечно-сосудистых заболевани¤х (артериальной гипертензии, аритми¤х, генерализованном атеросклерозе), гипертиреозе, аденоме предстательной железы, сахарном диабете, обструкции шейки мочевого пузыр¤ (например, вследствие гипертрофии предстательной железы), эпилепсии.  ак и в случае применени¤ любых местных сосудосуживающих средств, следует соблюдать осторожность при назначении препарата ¬иброцилЃ пациентам с выраженными реакци¤ми на симпатомиметики, про¤вл¤ющимис¤ в виде бессонницы, головокружени¤, тремора, сердечной аритмии или повышени¤ ј?.

Vibrocil - nasal drops with lavender oil for children from 1 year old and adults.
Х The unique dual formula of the drug Vibrocil with vasoconstrictor and antihistamine components makes the procedure for treating rhinitis mild and gentle.
Х Due to the gentle effect, the drug is approved for use within 7 days.
Х A gentle approach to the treatment of rhinitis in children and adults.

pharmachologic effect

VibrocilЃ is a combined preparation containing phenylephrine and dimethindene. Phenylephrine is a sympathomimetic, when applied topically, it has a moderate vasoconstrictor effect (due to stimulation of ? 1-adrenergic receptors located in the venous vessels of the nasal mucosa), eliminates edema of the nasal mucosa and its paranasal sinuses. Dimetindene is an anti-allergic agent - an antagonist of histamine H1 receptors; does not reduce the activity of the ciliated epithelium of the nasal mucosa.

Side effect

Determination of the frequency of side effects (WHO): very often (> 1/10), often (from> 1/100 to <1/10), infrequently (from> 1/1000 to <1/100), rarely (from> 1 / 10,000 to <1/1000), very rare (from <1/10 000, including individual messages). From the respiratory system: rarely - discomfort in the nose, dryness in the nose, nosebleeds. Local reactions: rarely - burning sensation in the area of ??application. If any of the above side effects are aggravated, or the patient has noticed any other side effects, he should inform the doctor about it.

Contraindications for use

hypersensitivity to phenylephrine, dimethindene maleate or other components of the drug; atrophic rhinitis (including with fetid discharge - ozena); simultaneous administration of MAO inhibitors and a period up to 14 days after their cancellation; angle-closure glaucoma; children's age up to 1 year.

The drug should be used with caution in cardiovascular diseases (arterial hypertension, arrhythmias, generalized atherosclerosis), hyperthyroidism, prostate adenoma, diabetes mellitus, bladder neck obstruction (for example, due to prostatic hypertrophy), epilepsy. As with the use of any local vasoconstrictor drugs, care should be taken when prescribing VibrocilЃ to patients with severe reactions to sympathomimetics, manifested in the form of insomnia, dizziness, tremors, cardiac arrhythmias or increased blood pressure.

Application during pregnancy and lactation

Given the possible systemic vasoconstrictor effect, VibrocilЃ is not recommended for use during pregnancy and lactation (breastfeeding).

Application in children

Children under 1 year of age: Contraindicated. Children aged 1 to 6 years (under the supervision of adults): 1-2 drops in each nasal passage 3-4 times / day. Children aged 6 to 12 years (under the supervision of adults): 3-4 drops in each nasal passage 3-4 times / day. Special instructions VibrocilЃ should not be used continuously for more than 7 days without consulting a doctor. Prolonged or excessive use of the drug can cause tachyphylaxis and the 'rebound' effect associated with the re-development of nasal congestion (rhinitis medicamentosa), leading to the development of a systemic vasoconstrictor effect. The recommended dose of VibrocilЃ should not be exceeded. Otherwise, the development of manifestations of the systemic action of the drug, especially in children and elderly patients, is possible.In children under the age of 6, only nasal drops are used. VibrocilЃ does not have a sedative effect (does not affect the speed of psychomotor reactions). Influence on the ability to drive vehicles and mechanisms Does not affect.

Overdose

An overdose of VibrocilЃ can cause sympathomimetic effects, for example, heart palpitations, premature contraction of the ventricles of the heart, headache in the occiput, tremors, fatigue, increased blood pressure, emotional excitement, insomnia, pallor of the skin. The drug can also cause mild sedation, dizziness, stomach pain, nausea, and vomiting.

Treatment: the use of activated charcoal, laxatives in young children; in adults and children over 6 years old - taking a large amount of liquid. There is no specific antidote. The increased blood pressure caused by phenylephrine can be eliminated with the use of alpha-blockers.

Drug interactions

Phenylephrine (like other vasoconstrictor drugs) is contraindicated in patients receiving MAO inhibitors at this time or have received them within the previous 2 weeks. You should not simultaneously prescribe the drug with tri- and tetracyclic antidepressants, beta-blockers.