Veldeksal solution for injection 25mg / ml, 2ml No. 5

• For parenteral administration: relief of pain syndrome of various origins (including postoperative pain, pain in bone metastases, post-traumatic pain, pain in renal colic, algomenorrhea, sciatica, sciatica, neuralgia, toothache);

• symptomatic treatment of acute and chronic inflammatory, inflammatory-degenerative and metabolic diseases of the musculoskeletal system (including rheumatoid arthritis, osteoarthritis, spondyloarthritis: ankylosing spondylitis, reactive arthritis, psoriatic arthritis).

For parenteral administration (i / m or i / v), the recommended dose for adults is 50 mg every 8-12 hours For patients with impaired liver or kidney function, elderly patients, the initial dose is no more than 50 mg / day.

The solution for intravenous and intramuscular administration is transparent, colorless, with a characteristic smell of alcohol.

1 ml

dexketoprofen trometamol 39.6 mg,

which corresponds to the content of dexketoprofen 25 mg

• Peptic ulcer and duodenal ulcer,

• gastrointestinal bleeding,

• active bleeding of various origins,

• increased bleeding

• anticoagulant therapy,

• Crohn's disease,

• nonspecific ulcerative colitis,

• bronchial asthma (including history),

• severe heart failure

• severe renal failure

• severe liver failure

• pregnancy,

• lactation,

• children under 18 years of age,

• hypersensitivity to dexketoprofen or other NSAIDs.

pharmachologic effect

NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is based on the inhibition of prostaglandin synthesis due to the suppression of COX. The analgesic effect occurs 30 minutes after administration, the duration of the action is 4-6 hours.

Pharmacokinetics

After taking the drug inside, Cmax of dexketoprofen in humans is achieved on average after 30 minutes (15-60 minutes). Plasma protein binding - 99%. Average Vd - less than 0.25 l / kg. T1 / 2 is 1.65 hours. It is metabolized. It is excreted mainly by the kidneys in the form of metabolites.

Side effect

From the digestive system: heartburn, abdominal pain; rarely - erosive and ulcerative lesions of the gastrointestinal tract. From the nervous system: headaches, dizziness, nervousness, sleep disturbance, paresthesia. From the side of the cardiovascular system: palpitations, increased blood pressure. Allergic reactions: skin rash, bronchospasm.

Others: chills, swelling of the limbs, photosensitivity; rarely - a change in the picture of peripheral blood, renal dysfunction.

Application during pregnancy and lactation

Use during pregnancy and lactation is contraindicated.

Application for violations of liver function

Contraindicated in liver failure. For patients with impaired liver function, the initial dose is no more than 50 mg / day.

Application for impaired renal function

Contraindicated in renal failure. For patients with impaired renal function, the initial dose is no more than 50 mg / day.

Application in children

The drug is contraindicated for use in children and adolescents under the age of 18 years.

Use in elderly patients

Care should be taken when prescribing the drug to elderly patients. For the elderly, the initial dose is no more than 50 mg / day.

special instructions

Care should be taken when prescribing the drug to elderly patients, patients with allergic reactions, with systemic diseases of the connective tissue and patients with impaired hematopoiesis. Patients should be informed that in the event of side effects, as well as in the absence of a clinical effect within 3-5 days of treatment, it is necessary to inform the attending physician about it. Special care is required with the simultaneous use of dexketoprofen with phenytoin, sulfonamides and drugs that reduce blood clotting. Influence on the ability to drive vehicles and mechanisms Since dexketoprofen can cause a decrease in the ability to concentrate, it should be used with caution in patients engaged in potentially hazardous activities,requiring increased attention and speed of psychomotor reactions.

Drug interactions

With the simultaneous use of dexketoprofen with other NSAIDs, the risk of side effects may increase. With simultaneous use with lithium preparations, it is possible to increase the concentration of the latter in the blood plasma. Use dexketoprofen with caution less than 24 hours before the start of use or after the end of methotrexate therapy. the concentration of the latter in blood plasma (and therefore toxicity) may increase. Some cases of bleeding with the simultaneous use of NSAIDs and anticoagulants are described.