Velaxin tablets 75mg, No. 28
Expiration Date: 05/2027
Russian Pharmacy name:
Велаксин таблетки 75мг, №28
Depression of various etiologies, treatment and prevention.
Inside, during meals.
The recommended starting dose is 75 mg in 2 divided doses (37.5 mg each) daily. If after several weeks of treatment there is no significant improvement, the daily dose can be increased to 150 mg (2 tablets, 75 mg per day). If, according to the doctor, a higher dose is needed (severe depressive disorder or other conditions requiring hospital treatment), you can immediately prescribe 150 mg in 2 divided doses (2 tablets, 75 mg per day). Thereafter, the daily dose can be increased by 75 mg every 2-3 days until the desired therapeutic effect is achieved. The maximum daily dose of VelaxinЃ is 375 mg. After achieving the desired therapeutic effect, the daily dose can be gradually reduced to the minimum effective level.
Supportive care and relapse prevention. Supportive treatment can last 6 months or more. The minimum effective dose used in the treatment of a depressive episode is prescribed.
Renal failure: with mild renal failure (GFR more than 30 ml / min), no dosage adjustment is required. With moderate renal failure (GFR 10-30 ml / min), the dose should be reduced by 25-50%. Due to the increase in T1 / 2 of venlafaxine and EFA, such patients should take the entire dose once a day. It is not recommended to use venlafaxine in severe renal failure (GFR less than 10 ml / min), as reliable data on such therapy are not available. Patients on hemodialysis can receive 50% of the usual daily dose of venlafaxine after completing hemodialysis.
Hepatic impairment: With mild hepatic impairment (PT <14 s), no dosage adjustment is required. With moderate hepatic impairment (PV 14-18 s), the dose should be reduced by 50%. It is not recommended to use venlafaxine in severe hepatic impairment, as reliable data on such therapy are not available.
Elderly patients. By itself, the elderly age of the patient does not require a change in the dose, however (as with the appointment of other drugs), caution is required in the treatment of elderly patients, for example, due to the possibility of impaired renal function. The lowest effective dose should be used. When the dose is increased, the patient should be under close medical supervision.
Stop taking VelaxinЃ. At the end of taking VelaxinЃ, it is recommended to gradually reduce the dosage of the drug, at least for a week, and monitor the patient's condition in order to minimize the risk associated with drug withdrawal (see below).
The period required to completely stop taking the drug depends on its dosage, the duration of the course of treatment and the individual characteristics of the patient.
| Pills | 1 tab. |
| active substance: | |
| venlafaxine hydrochloride | 42.42 mg |
| 84.84 mg | |
| (equivalent to 37.5 mg and 75 mg venlafaxine, respectively) | |
| excipients: lactose monohydrate - 84.93 / 169.86 mg; MCC - 36/72 mg; sodium carboxymethyl starch - 12.6 / 25.2 mg; anhydrous colloidal silicon dioxide - 1.35 / 2.7 mg; magnesium stearate - 2.7 / 5.4 mg |
hypersensitivity;
simultaneous administration of MAO inhibitors (see 'Interaction');
severe impairment of kidney and / or liver function (glomerular filtration rate (GFR) - less than 10 ml / min);
age up to 18 years (safety and effectiveness for this age group have not been proven);
established or suspected pregnancy;
lactation period.
With care: recent myocardial infarction, unstable angina pectoris, arterial hypertension, tachycardia, a history of convulsive syndrome, increased intraocular pressure, angle-closure glaucoma, a history of manic conditions, a predisposition to hemorrhages from the skin and mucous membranes, reduced body mass.