Velafax tablets 75mg, No. 28

Treatment of depression of various etiologies, including depression accompanied by symptoms of anxiety.

Inside, during meals, preferably at the same time, without chewing and drinking liquid.

For the treatment of depression, the recommended initial dose of VelafaxЃ is 37.5 mg 2 times a day daily. If after several weeks of treatment there is no significant improvement, the dose can be increased to 150 mg / day - 75 mg 2 times a day.

If it is necessary to use the drug in a higher dose for severe depressive disorder or other conditions requiring inpatient treatment, you can immediately prescribe 75 mg 2 times a day. Thereafter, the daily dose can be increased by 75 mg every 2-3 days until the desired therapeutic effect is achieved. The maximum daily dose of VelafaxЃ is 375 mg. After achieving the desired therapeutic effect, the daily dose can be gradually reduced to the minimum effective level.

Supportive treatment continues for 6 months or more. The drug is prescribed in the minimum effective dose used in the treatment of a depressive episode.

In case of renal failure of mild severity (glomerular filtration rate more than 30 ml / min), correction of the dosage regimen is not required.

In case of moderate renal failure (glomerular filtration rate 10Ц30 ml / min), the dose should be reduced by 25Ц50%. Due to the T1 / 2 lengthening of venlafaxine and its active metabolite, such patients should take the entire dose once a day.

In case of severe renal failure (glomerular filtration rate less than 10 ml / min), the use of VelafaxЃ is not recommended, since the experience of such therapy is limited.

Patients on hemodialysis can receive 50% of the usual daily dose of venlafaxine after completing hemodialysis.

With mild hepatic impairment (PT less than 14 s), dosage adjustment is not required.

With moderate hepatic impairment (PT from 14 to 18 s), the dose should be reduced by 50%.

In severe hepatic impairment, the use of VelafaxЃ is not recommended, since the experience of such therapy is limited.

Elderly patients do not need dose adjustment, however (as with the appointment of other drugs), care must be taken in treatment, for example, due to the possibility of impaired renal function. Therefore, in elderly patients, the lowest effective dose of the drug should be used; close medical supervision is indicated if necessary to increase the dose.

Stopping taking VelafaxЃ

At the end of treatment, it is recommended to reduce the dose gradually. When used in a dose equal to or exceeding 75 mg for a course of 7 days or more, the drug is canceled for at least a week, gradually reducing the dose. When used in high doses for a course of more than 6 weeks, the period required to completely stop taking the drug is at least 2 weeks. The appearance of symptoms of a relapse of the disease during the period of discontinuation of the VelafaxЃ drug requires the appointment of the initial dose of the drug or a more gradual and prolonged reduction.

individual intolerance to venlafaxine and other components of the drug;

simultaneous administration of MAO inhibitors (see 'Interaction');

severe impairment of renal function (Cl creatinine <10 ml / min) and / or liver;

age under 18;

pregnancy;

lactation period.

With care: recent myocardial infarction, unstable angina pectoris; arterial hypertension; tachycardia; a history of convulsive syndrome; increased intraocular pressure, angle-closure glaucoma; a history of manic conditions; hyponatremia; hypovolemia; dehydration; concomitant use of diuretics; suicidal tendencies; a predisposition to bleeding from the skin and mucous membranes; initially reduced body weight.