Valparin XP tablets 300mg, No. 100
Expiration Date: 05/2027
Russian Pharmacy name:
Вальпарин ХР таблетки 300мг, №100
epilepsy of any genesis;
epileptic seizures (including generalized and partial, as well as against the background of organic brain diseases);
disorders of character and behavior associated with epilepsy;
febrile seizures in children;
manic-depressive syndrome with bipolar course, which does not respond to treatment with lithium or other drugs.
Inside.
Capsules: do not chew, regardless of food, with a small amount of liquid, 2-3 times a day.
Syrup and drops: regardless of food, with a little liquid, 2-3 times a day.
Tablets: do not chew, regardless of food, with a small amount of liquid, 1-2 times a day.
For adults, the initial daily dose is 600 mg, with a gradual increase in the dose every 3 days until a clinical effect is achieved (the disappearance of seizures).
With monotherapy, the initial dose is 5-15 mg / kg / day, then the dose is gradually increased by 5-10 mg / kg per week.
The average daily dose is about 1000-2000 mg / day, ie. 20-30 mg / kg. If necessary, the dose is increased to 2500 mg / day.
The maximum dose is 30 mg / kg / day (it can be increased if it is possible to organize monitoring of plasma concentration up to 60 mg / kg / day).
With combination therapy - 10-30 mg / kg / day, followed by an increase in the dose by 5-10 mg / kg per week.
Children weighing more than 25 kg: the initial daily dose is 300 mg (regardless of body weight), it can be gradually increased until the clinical effect is achieved (the disappearance of seizures) up to 20-30 mg / kg per day. The initial dose for monotherapy is 5-15 mg / kg / day, then it is gradually increased by 5-10 mg / kg per week. The maximum dose is 30 mg / kg / day (it can be increased if it is possible to organize monitoring of plasma concentration up to 60 mg / kg / day).
Children weighing 17-25 kg (tablets), 7.5-25 kg (capsules, syrup, drops): the average daily dose for monotherapy is 15-45 mg / kg, the maximum is 50 mg / kg. In combination therapy - 30-100 mg / kg / day.
Average daily doses - see table.
Table
Average daily doses of KonvuleksЃ
| Body weight of a child, teenager or adult, kg | Dose, mg / day | Number of capsules (150 mg) | Number of capsules or tablets (300 mg) | Number of capsules or tablets (500 mg) | Amount of syrup, ml | Number of drops |
| 7.5-14 | 150-450 | 1-3 | 3-9 | 15Ц45 | ||
| 14-21 | 300-600 | 2-4 | 1-2 | 6-12 | 30-60 | |
| 21Ц32 | 600-900 | 4-6 | 2-3 | 12-18 | 60Ц90 | |
| 32-50 | 900-1500 | 3-5 | 2-3 | |||
| 50Ц90 | 1500-2500 | 3-5 |
Elderly and patients with renal insufficiency may be prescribed smaller doses of the drug (careful dose selection is required).
| Soft capsules | 1 caps. |
| valproic acid | 150 mg |
| 300 mg | |
| 500 mg | |
| excipients: sorbitol (Karion 83); glycerin 85%; gelatin; titanium dioxide; iron oxide red E172; hydrochloric acid 25%; shellac; iron oxide black E172; hypromellose phthalate; dibutyl phthalate |
in a contour acheikova packing 10 pcs .; in a box of 10 packages (150 and 500 mg) or in a blister strip packaging 20 pcs.; in a box of 5 packages (300 mg).
| Syrup for children | 100 ml |
| valproic acid | 4.338 g |
| excipients: sodium hydroxide; lycasin 80/55; saccharin sodium; sodium cyclamate; methylhydroxybenzoate; propyl hydroxybenzoate; sodium chloride; flavors raspberry (9/372710) and peach (9/030307); purified water |
in bottles of 100 ml, complete with a measuring syringe; in the box 1 set.
| Oral drops | 1 ml |
| valproic acid | 300 mg |
| auxiliary substances: purified water |
in bottles of 100 ml; in the box 1 bottle.
| Sustained-release film-coated tablets | 1 tab. |
| valproic acid | 300 mg |
| 500 mg | |
| excipients: citric acid monohydrate; ethyl cellulose; Eudragit RS30D; talcum powder; colloidal anhydrous silicon; magnesium stearate; Eudragit L30D; dibutyl phthalate; sodium carmellose; macrogol 6000; titanium dioxide; vanillin; simethicone |
in polyethylene bottles or dark glass bottles of 50 or 100 pcs .; in a cardboard box 1 bottle
hypersensitivity;
severe dysfunction of the liver and / or pancreas;
porphyria;
severe thrombocytopenia;
hemorrhagic diathesis;
pregnancy (I trimester);
breast-feeding;
children under 3 years of age (tablets).