Validol tablets 60mg, No. 16

Functional cardialgia, neuroses, as an antiemetic for sea and air sickness.

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Sublingual, 2-3 times / day. The frequency and duration of admission is determined depending on the effectiveness of the treatment. In the absence or insufficient severity of the therapeutic effect in the next 5-10 minutes after administration, another therapy must be prescribed.

Levomenthol solution in menthyl isovalerate (validol) - 60 mg

Hypersensitivity to the active substance, age up to 18 years.

Sublingual tablets

Composition:

Active substance:

levomenthol solution in menthil isovalerate (validol) - 60 mg

Clinical and pharmacological group: A drug with a reflex vasodilating effect

Pharmaco-therapeutic group: Coronarodilating agent of reflex action

pharmachologic effect

Coronarodilator of reflex action, causes sedation. The reflex vasodilating effect is due to irritation of the sensitive nerve endings. Stimulates the production and release of enkephalins, endorphins and a number of other peptides, histamine, kinins (due to irritation of mucosal receptors), which are actively involved in the regulation of vascular permeability, the formation of pain.

Dextrose (if present in the composition of the dosage form used) is phosphorylated in tissues with the formation of glucose-6-phosphate, which is actively involved in various metabolic processes.

With sublingual administration, the therapeutic effect occurs on average after 5 minutes, while up to 70% of the active substance is released within 3 minutes.

Pharmacokinetics

With sublingual administration of levomenthol, the solution in menthil isovalerate is absorbed from the oral mucosa. It is metabolized in the liver and excreted by the kidneys in the form of glucuronides.

When using dosage forms containing dextrose (glucose), the latter is completely absorbed by the body; It is not excreted by the kidneys (appearance in the urine is a pathological sign).

Indications

Functional cardialgia, neuroses, as an antiemetic for sea and air sickness.

Dosage regimen

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Sublingual, 2-3 times / day. The frequency and duration of admission is determined depending on the effectiveness of the treatment. In the absence or insufficient severity of the therapeutic effect in the next 5-10 minutes after administration, another therapy must be prescribed.

Side effect

Possibly: nausea, watery eyes, dizziness, allergic reactions.

Contraindications for use

Hypersensitivity to the active substance, age up to 18 years.

Application during pregnancy and lactation

Application during pregnancy and lactation (breastfeeding) is possible if the expected benefit of therapy to the mother outweighs the potential risk to the fetus.

special instructions

If necessary, the use of dosage forms containing dextrose (glucose) requires caution.

Simultaneous alcohol intake is not recommended.

Influence on the ability to drive vehicles and mechanisms

When using, patients should be careful when driving vehicles and other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Drug interactions

With simultaneous use with drugs that have a depressing effect on the central nervous system, an increase in their action is observed.