Urofuragin tablets 50mg, No. 30
Expiration Date: 05/2027
Russian Pharmacy name:
Урофурагин таблетки 50мг, №30
The drug is taken orally, after meals. For treatment, 100-200 mg is used 2-3 times / day for 7-10 days. If necessary, after a 10-15-day break, the courses of treatment are repeated. The maximum daily dose is 600 mg. For the prevention of infectious complications after surgical interventions on the organs of the genitourinary system, a single dose of 50 mg is used 30 minutes before the operation.
Tablets are yellow-orange in color, round, flat-cylindrical, with a score on one side and a chamfer on both sides.
furazidine 50 mg
impaired renal function; urosepsis and renal parenchymal infections; impaired liver function; pregnancy; breastfeeding period; children and adolescents up to 18 years old; deficiency of lactase, sucrase / isomaltase, lactose intolerance, fructose, glucose-galactose malabsorption; hypersensitivity to furazidine, other components of the drug; hypersensitivity to nitrofuran derivatives.
The drug should be prescribed with caution in case of anemia, lung diseases (especially in patients over 65 years of age), diseases of the nervous system, diabetes mellitus, porphyria, deficiency of glucose-6-phosphate dehydrogenase, B vitamins and folic acid.
pharmachologic effect
Antimicrobial agent of a wide spectrum of action, belongs to the group of nitrofurans. The mechanism of action is associated with inhibition of nucleic acid synthesis. Under the influence of nitrofurans, the activity of the respiratory chain and the tricarboxylic acid cycle (Krebs cycle) is suppressed, as well as the suppression of other biochemical processes of microorganisms, which leads to the destruction of their membrane or cytoplasmic membrane. Active against gram-positive cocci: Staphylococcus spp., Streptococcus spp .; gram-negative rods: Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp. Resistant to furazidine: Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., Most strains of Proteus spp., Serratia spp. Depending on the concentration, it has a bactericidal or bacteriostatic effect.Against most bacteria, the bacteriostatic concentration ranges from 10 to 20 ?g / ml. The bactericidal concentration is approximately 2 times higher.
Pharmacokinetics
Suction
Absorbed from the small intestine by passive diffusion. The absorption of nitrofurans from the distal segment of the small intestine exceeds the absorption from the proximal and medial segment by 2 and 4 times, respectively. Poorly absorbed from the colon. Cmax in serum lasts from 3 to 7-8 hours. Distribution Distributed evenly. It is found in high concentrations in lymph; in bile its concentration is several times higher than in serum, in cerebrospinal fluid - several times lower than in serum; saliva contains up to 30% of its concentration in serum; in the blood and tissues, the concentration is low, which is associated with its rapid excretion, while its concentration in the urine is much higher than in the blood. Metabolism and excretion Metabolized in the liver (less than 10%), with a decrease in renal excretory function, the metabolic rate increases.It is found in urine after 3-4 hours. Does not change urine pH, unlike nitrofurantoin. It is excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations in urine, the process of filtration and secretion prevails, at high concentrations, secretion decreases and reabsorption increases. As a weak acid, it does not dissociate; at acidic pH values, urine undergoes intense reabsorption, which can increase systemic side effects.As a weak acid, it does not dissociate; at acidic pH values, urine undergoes intense reabsorption, which can increase systemic side effects.As a weak acid, it does not dissociate; at acidic pH values, urine undergoes intense reabsorption, which can increase systemic side effects.
Side effect
Blood and lymphatic system disorders: agranulocytosis, thrombocytopenia, aplastic anemia, eosinophilia. From the nervous system: dizziness, headache, drowsiness, weakness, peripheral neuropathy, the development of polyneuritis. From the side of the organ of vision: visual impairment. From the side of the vessels: intracranial hypertension. From the respiratory system: shortness of breath, chest pain, cough with and without phlegm, interstitial pneumonitis, pulmonary fibrosis. From the gastrointestinal tract: nausea, vomiting, loss of appetite, anorexia, diarrhea, pancreatitis. From the liver and biliary tract: liver dysfunction, cholestatic jaundice, hepatitis. Musculoskeletal and connective tissue disorders: myalgia, arthralgia. Skin and subcutaneous tissue disorders: skin rash (including papular), enanthema, pruritus, exfoliative dermatitis, reversible alopecia.Allergic reactions: angioedema, urticaria, erythema multiforme.
Others: fever.
Contraindications for use
impaired renal function; urosepsis and renal parenchymal infections; impaired liver function; pregnancy; breastfeeding period; children and adolescents up to 18 years old; deficiency of lactase, sucrase / isomaltase, lactose intolerance, fructose, glucose-galactose malabsorption; hypersensitivity to furazidine, other components of the drug; hypersensitivity to nitrofuran derivatives.
The drug should be prescribed with caution in case of anemia, lung diseases (especially in patients over 65 years of age), diseases of the nervous system, diabetes mellitus, porphyria, deficiency of glucose-6-phosphate dehydrogenase, B vitamins and folic acid.
Application for violations of liver function
The use of the drug is contraindicated in case of impaired liver function.
Application for impaired renal function
The use of the drug is contraindicated in case of impaired renal function, urosepsis and infection of the renal parenchyma.
Application in children
The use of the drug is contraindicated in children and adolescents under 18 years of age.
Use in elderly patients
The drug should be prescribed with caution in patients over 65 years of age with lung diseases.
special instructions
To prevent the development of side effects, drink plenty of fluids. To prevent the development of neuritis, it is necessary to prescribe vitamins of group B. When using the drug, urine is stained brown. With prolonged use of the drug, it is necessary to monitor the picture of peripheral blood, kidney, liver and lung function. False positive results are possible when determining glucose in urine using enzymatic methods. When using the drug, the development of diarrhea caused by Clostridium difficile (pseudomembranous colitis) is possible. In mild cases, discontinuation of the drug is sufficient; in severe cases, appropriate treatment must be prescribed. Do not use drugs that inhibit intestinal motility.
Influence on the ability to drive vehicles and use mechanisms
During the period of treatment, one should refrain from driving and engaging in other activities that require increased concentration of attention and speed of psychomotor reactions.
Overdose
Symptoms: neurotoxic reactions, polyneuritis, abnormal liver function, acute toxic hepatitis.
Treatment: drug withdrawal, intake of large amounts of fluids, symptomatic therapy, antihistamines, B vitamins. There is no specific antidote.
Drug interactions
With simultaneous use with ristomycin, chloramphenicol, sulfonamides, the risk of hematotoxic action increases. Avoid the simultaneous use of other derivatives of nitrofuran, as well as drugs that acidify urine (including ascorbic acid, calcium chloride). Urinary alkalizing drugs accelerate the excretion of furazidine in the urine. Ethanol can increase the severity of side effects. Probenecid and sulfinpyrazone reduce urinary excretion of furazidine. This can lead to the accumulation of furazidine and an increase in its toxicity. With the simultaneous use of magnesium-containing antacids, the absorption of furazidine decreases.