Troxymetacin gel for external use, tube 40 g

pharmachologic effect

Gel Troxymetacin is a combined preparation for topical use, which includes indomethacin and troxerutin. Indomethacin has a pronounced anti-inflammatory, analgesic and decongestant effect, leading to pain relief, reduction of edema and reduction of the recovery time of the affected tissues. The main mechanism of action is associated with suppression of prostaglandin synthesis by reversible blockade of cyclooxygenase 1 and 2. Troxerutin (trihydroxyethylrutinoside) is a bioflavonoid. It has an angioprotective effect. Reduces capillary permeability and exhibits venotonic effect. Blocks the venodilating effect of histamine, bradykinin and acetylcholine. It has an anti-inflammatory effect on the peri-venous tissue, reduces capillary fragility and has some antiplatelet effect. Reduces puffiness,improves trophism in various pathological changes associated with venous insufficiency. When applied to the skin, Troxymethacin gel suppresses the inflammatory edematous reaction, reduces pain and temperature in inflammation foci located on the surface and in depth, reaching the blood vessels located there. It has a pronounced venotonic, capillary-protective effect.

Indications

For symptomatic treatment:

- in the complex therapy of chronic venous insufficiency of the lower extremities (varicose veins) - to relieve swelling, feeling of heaviness and pain in the legs

- superficial thrombophlebitis, phlebitis

post-phlebitis conditions

- rheumatic lesions of soft tissues: tendovaginitis, bursitis, fibrositis, periarthritis

- postoperative edema, contusion, dislocation, sprains.

Contraindications

- Hypersensitivity to the components of the drug Troxymetacin

- hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs)

- III trimester of pregnancy and the period of breastfeeding

- children's age up to 14 years (due to the lack of clinical experience of use)

- violation of the integrity of the skin.

Carefully:

Simultaneous use of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, polyps of the nasal mucosa.

special instructions

The drug should be applied only to intact skin areas, avoid contact with eyes and mucous membranes.

After applying the drug, do not apply an occlusive dressing.

In case of contact with eyes, mucous membranes or open wound surfaces, local irritation is observed - tearing, redness, burning, pain.

The necessary measures in this case are washing the affected area with an abundant amount of distilled water or saline until the complaints disappear or decrease.

Sodium benzoate and dimethyl sulfoxide contained in Troxymetacin gel as excipients can irritate the skin.

Influence on the ability to drive vehicles and mechanisms:

The drug does not affect the ability to perform potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (including driving, working with moving mechanisms).

Structure

gel for external use Troxymetacin 1 g:

- indomethacin 30 mg

- troxerutin 20 mg

Excipients:

carbomer 15 mg, disodium edetate 0.5 mg, sodium benzoate 2.5 mg, macrogol-400 522 mg, isopropanol 150 mg, dimethyl sulfoxide 150 mg, purified water 110 mg.

Method of administration and dosage

Gel Troxymetacin is applied externally.

3-4 times a day by rubbing the gel with a thin layer into the skin of painful areas of the body.

The amount required for one rubbing is about 4-5 cm of gel squeezed out of the tube.

The total daily amount should not exceed 20 cm of gel.

The duration of treatment should not exceed 10 days.

Side effects

Local reactions:

The appearance of symptoms of hypersensitivity from the skin is possible - contact dermatitis, itching, redness, rash, a feeling of warmth and burning at the site of application.

Drug interactions

Gel Troxymethacin can enhance the effect of drugs that cause photosensitization.

No clinically significant interactions with other drugs have been described.

Overdose

There is no evidence of cases of overdose with topical application.

If large amounts of the drug are accidentally swallowed, a burning sensation in the mouth, salivation, nausea, and vomiting may occur.

Treatment: washing of the mouth and stomach, if necessary, symptomatic treatment.

Storage conditions

At a temperature not higher than 25 ° C.

Keep out of the reach of children.

Shelf life

2 years

Active substance

Indomethacin, Troxerutin

Name ENG

TROXIMETACIN

Clinical and pharmacological group

Drug with anti-inflammatory and angioprotective action for external use

ATX code

Indomethacin in combination with other drugs

Dosage

30mg / g + 20mg / g x 40g

Structure

Gel for external use Troxymetacin 1 g:

- indomethacin 30 mg

- troxerutin 20 mg

Excipients:

carbomer 15 mg, disodium edetate 0.5 mg, sodium benzoate 2.5 mg, macrogol-400 522 mg, isopropanol 150 mg, dimethyl sulfoxide 150 mg, purified water 110 mg.

Indications

For symptomatic treatment:

- in the complex therapy of chronic venous insufficiency of the lower extremities (varicose veins) - to relieve swelling, feeling of heaviness and pain in the legs

- superficial thrombophlebitis, phlebitis

post-phlebitis conditions

- rheumatic lesions of soft tissues: tendovaginitis, bursitis, fibrositis, periarthritis

- postoperative edema, contusion, dislocation, sprains.

Contraindications

Hypersensitivity to the components of the drug Troxymetacin

- hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs)

- III trimester of pregnancy and the period of breastfeeding

- children's age up to 14 years (due to the lack of clinical experience of use)

- violation of the integrity of the skin.

With care: Simultaneous use of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, nasal mucosa polyps.

INN / Active ingredient

Indomethacin, Troxerutin

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 3 years

Specifications

Scope of the drug

Heart, vessels, blood

Release form

Gel

Manufacturer country

Bulgaria

Package quantity, pcs

one

Scope of application

Phlebology

,

Angiology

Minimum age from

14 years old

Way of introduction

Outwardly

,

On the skin

,

Locally

Vacation conditions

Without recipe

Brand name

VetProm AD

The amount of the dosage form in the primary package

40 g

Primary packaging type

Tuba

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Topical anti-inflammatory agent

Anatomical and therapeutic characteristics

M01AB51 Indomethacin, in combination with other drugs

Dosage form

Gel for external use

The target audience

Adult

Expiration date in days

730

Dosage (volume) of the substance in the preparation

Troxymetacin 1 g:

- indomethacin 30 mg

- troxerutin 20 mg

Package weight, g

25

Category

:

Improving blood circulation

,

Angioprotectors and microcirculation correctors

,

Lipid-lowering drugs

,

Hematopoietic stimulants

Mode of application

:

Gel Troxymetacin is applied externally.

3-4 times a day by rubbing the gel with a thin layer into the skin of painful areas of the body.

The amount required for one rubbing is about 4-5 cm of gel squeezed out of the tube.

The total daily amount should not exceed 20 cm of gel.

The duration of treatment should not exceed 10 days.

Information on technical characteristics, delivery set, country of manufacture