Tranexam solution 50mg / ml, No. 10

Pills

bleeding or the risk of bleeding in the background:

- enhancement of local fibrinolysis (uterine, including against the background of von Willebrand disease and other coagulopathies, nasal, gastrointestinal bleeding, hematuria, bleeding after prostatectomy, cervical conization for carcinoma, tooth extraction in patients with hemorrhagic diathesis);

- enhancement of generalized fibrinolysis (malignant neoplasms of the pancreas and prostate glands, operations on the chest organs, postpartum hemorrhage, manual separation of the placenta, leukemia, liver disease);

bleeding during pregnancy;

hereditary angioedema, allergic diseases (eczema, allergic dermatitis, urticaria, drug and toxic rash);

inflammatory diseases (tonsillitis, pharyngitis, laryngitis, stomatitis, aphthae of the oral mucosa).

Intravenous solution

bleeding or the risk of bleeding against the background of increased fibrinolysis, as generalized (bleeding during operations and in the postoperative period, postpartum bleeding, manual separation of the placenta, chorionic detachment, bleeding during pregnancy, malignant neoplasms of the pancreas and prostate glands, hemophilia, hemorrhagic complications of fibrinolytic therapy, thrombocytogenic purpura, leukemia, liver disease, previous streptokinase therapy) and local (uterine bleeding, after conization of the cervix for carcinoma, nasal, pulmonary, gastrointestinal, hematuria, bleeding after prostatectomy, tooth extraction in patients with hemorrhagic diathesis);

surgical interventions on the bladder;

surgical manipulations for systemic inflammatory reactions (sepsis, peritonitis, pancreatonecrosis, severe and moderate preeclampsia, shock of various etiologies and other critical conditions).

Pills

Inside.

With local fibrinolysis appoint 1000-1500 mg 2-3 times a day.

With profuse uterine bleeding, appoint 1000-1500 mg 3-4 times a day for 3-4 days.

With bleeding against the background of von Willebrand disease and other coagulopathies - 1000-1500 mg 3-4 times a day. The duration of the course of treatment is 3-10 days.

After the operation of conization of the cervix, appoint 1500 mg 3 times a day for 12-14 days.

For nosebleeds, 1000 mg is prescribed 3 times a day for 7 days.

Patients with coagulopathies after tooth extraction are prescribed 1000-1500 mg 3-4 times a day for 6-8 days.

In case of bleeding during pregnancy - 250-500 mg 3-4 times a day until the bleeding stops completely. The average duration of the course of treatment is 7 days.

In hereditary angioedema, 1000-1500 mg is prescribed 2-3 times a day, continuously or intermittently, depending on the presence of prodromal symptoms.

With symptoms of allergy and inflammation - 1000-1500 mg 2-3 times a day for 3-9 days, depending on the severity of the condition.

In generalized fibrinolysis, therapy begins with parenteral (i / v) administration of TranexamЃ followed by a switch to oral administration of 1000-1500 mg 2-3 times a day.

In case of impaired renal excretory function, correction of the dosage regimen is necessary: ??when the concentration of creatinine in the blood is 120Ц250 ?mol / l, 1000 mg is prescribed 2 times a day; at a creatinine concentration of 250Ц500 ?mol / l, 1000 mg is prescribed once a day; at a creatinine concentration of more than 500 ?mol / l, 500 mg is prescribed once a day.

Intravenous solution

In / in (drip, jet).

In generalized fibrinolysis, a single dose of 15 mg / kg is administered every 6Ц8 hours, the rate of administration is 1 ml / min.

In case of local fibrinolysis, it is recommended to administer the drug in a dose of 250-500 mg 2-3 times a day.

In case of prostatectomy or bladder surgery, 1 g is injected during the operation, then 1 g every 8 hours for 3 days, after which they switch to oral tablet form until gross hematuria disappears.

With a high risk of bleeding, with a systemic inflammatory reaction - at a dose of 10-11 mg / kg 20-30 minutes before the intervention.

Before tooth extraction, patients with coagulopathies are injected at a dose of 10 mg / kg, after tooth extraction, a tablet form of the drug is administered orally.

In case of impaired renal excretory function, the dosage regimen must be adjusted depending on the concentration of creatinine in the blood: when the concentration of creatinine in the blood is 120Ц250 µmol / l, 10 mg / kg is prescribed 2 times a day; at 250-500 ?mol / l - 10 mg / kg once a day; at> 500 ?mol / kg - 5 mg / kg once a day.

hypersensitivity to the drug;

subarachnoid hemorrhage.

With care: thrombosis (thrombosis of cerebral vessels, myocardial infarction, thrombophlebitis) or the threat of their development; thrombohemorrhagic complications (in combination with heparin and indirect anticoagulants); violation of color vision; hematuria from the upper urinary tract (obstruction by a blood clot is possible); renal failure (cumulation is possible).