Tizin Expert spray 0.1%, 10ml

Х Reduction of swelling of the nasal mucosa with rhinitis, including allergic rhinitis, acute respiratory infections with symptoms of rhinitis, hay fever.

Х Relief of nasal discharge from paranasal sinusitis and otitis media caused by the common cold.

Х Preparing patients for diagnostic manipulations in the nasal passages.

TizinЃ Expert, 0.05% dosed nasal spray is intended for children aged 2 to 6 years.

'TizinЃ Expert' nasal spray 0.1% dosage is intended for adults and children over 6 years old.

Adults and children over 6 years old - 0.1%

Х Up to 3 times a day, one dose of the drug is injected in the form of a 0.1% metered spray into each nostril. The dose depends on the individual sensitivity of the patient and the clinical response. Children aged 2-6 years - 0.05%

Х Unless otherwise prescribed, use one dose of the drug in the form of a 0.05% metered spray in each nostril 1-2 times a day.

Xylometazoline in the form of a metered-dose spray should not be used for more than 5-7 days, unless the doctor has recommended a different duration of treatment. After completion of therapy, the drug can be re-prescribed only after a few days. Always consult a doctor regarding the duration of use in children. In the case of chronic rhinitis, TizinЃ Expert 0.05% and 0.1% can be used only under medical supervision, taking into account the risk of atrophy of the nasal mucosa.

Composition:

1 ml of solution contains: active substance: xylometazoline hydrochloride 0.5 mg (0.05%) or 1 mg (0.1%); the amount of the active ingredient in one dose for 0.05% - 0.035 mg of xylometazoline hydrochloride; for 0.1% - 0.14 mg of xylometazoline hydrochloride;

excipients: glycerol - 8.5 mg, sorbitol - 5 mg, sodium dihydrogen phosphate dihydrate - 4 mg, sodium chloride - 3 mg, sodium phosphate dihydrate - 0.628 mg, sodium hyaluronate - 0.2 mg, water for injection - up to 1 ml ...

Х Hypersensitivity to any component of the drug;

Х atrophic rhinitis, thyrotoxicosis;

Х newborns and children under the age of 2 years (for nasal spray dosed 0.05%); children under 6 years of age (for nasal spray dosed 0.1%);

Х patients with severe cardiovascular diseases (for example, ischemic heart disease, angina pectoris, tachycardia, arterial hypertension, severe atherosclerosis);

Х patients with a history of surgical interventions on the meninges;

Х patients receiving monoamine oxidase (MAO) inhibitors or other drugs that can cause high blood pressure;

Х patients with increased intraocular pressure, especially with angle-closure glaucoma;

Х condition after transsphenoidal hypophysectomy.

Pharmacodynamics

Xylometazoline (an imidazole derivative) is an alpha-adrenostimulant that constricts the blood vessels of the nasal mucosa, eliminating edema and hyperemia of the mucous membrane. Facilitates nasal breathing with rhinitis. Hyaluronic acid, which is part of the drug, has a moisturizing effect when used in nasal medicines due to its ability to keep the mucous membranes moist and create optimal conditions for recovery processes. The action usually begins within 5-10 minutes.

Pharmacokinetics

When applied topically, it is practically not absorbed, plasma concentrations are so small that they cannot be determined by modern analytical methods. In humans, pharmacokinetic studies have not been conducted.

Carefully

In the following cases, 'TizinЃ Expert' can be used only after carefully weighing the benefits and risks of treatment:

Х patients with hypersensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure;

Х patients with pheochromocytoma;

Х patients with endocrine diseases (eg, hyperthyroidism, diabetes mellitus);

Х patients with prostatic hyperplasia;

Х patients with porphyria.

Pregnancy and lactation

Xylometazoline should not be used during pregnancy, as the effects of this drug on the fetus have not been studied in clinical trials. The drug should not be used during breastfeeding, since it is not known whether the active substance is excreted in breast milk.

Side effect

Respiratory tract 'TizinЃ Expert' can cause transient slight irritation of the nose (burning) in susceptible people, sneezing. Often (> 1Ц <10%), increased swelling of the nasal mucosa (reactive hyperemia) may occur after discontinuation of the drug. Prolonged or too frequent use of xylometazoline, or its use in high doses, can lead to a burning sensation in the nose or dryness of the mucous membrane, as well as reactive nasal congestion, with the development of drug-induced rhinitis, paresthesia, sneezing, hypersecretion. This effect can be observed even 5-7 days after the completion of treatment, and with prolonged use it can cause chronic inflammation of the mucous membrane with the formation of crusts (dry rhinitis). Nervous system In rare cases (> 0.01% - <1%), headache, insomnia,visual impairment, fatigue and depression (with prolonged use in high doses). Cardiovascular system In isolated cases (0.1% - <1%), local intranasal use of sympathomimetics may be accompanied by systemic effects such as palpitations, tachycardia, arrhythmias and increased blood pressure.

Overdose

Symptoms Overdose or accidental ingestion of the drug can lead to the following symptoms: dilated pupils, nausea, vomiting, cyanosis, fever, convulsions, tachycardia, arrhythmia, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders. In addition, the following symptoms may be observed: suppression of the function of the central nervous system, accompanied by drowsiness, a decrease in body temperature, bradycardia, hypotension, apnea and coma. Treatment The use of activated carbon, gastric lavage, artificial respiration with the introduction of oxygen. To lower blood pressure, phentolamine 5 mg in saline is used slowly intravenously or 100 mg orally. Vasopressor agents are contraindicated. If necessary, use antipyretic and anticonvulsants.

Interaction with other drugs

The simultaneous use of MAO inhibitors such as tranylcypromine or tricyclic antidepressants can lead to an increase in blood pressure due to the cardiovascular effects of these substances.

special instructions

Long-term use (more than 7 days) and overdose of sympathomimetics that have a decongestant effect can lead to reactive hyperemia of the nasal mucosa. As a result, nasal breathing becomes difficult, which leads to the fact that the patient begins to use the drug repeatedly or even constantly. This can lead to chronic swelling (medication rhinitis), and eventually even to atrophy of the nasal mucosa (ozenes). In milder cases, to improve the patient's condition, you can first stop the introduction of sympathomimetic in one nostril, and after reducing complaints, continue to inject it into the other nostril in order to at least partially provide nasal breathing. The recommended doses should not be exceeded, especially in children and the elderly. It is not recommended to use the drug continuously for more than 7 days.If a medicinal product has become unusable or the expiration date has expired, do not throw it into waste water or outside! Place the medicine in a bag and put it in the trash can. These measures will help protect the environment!