Tiloron-SZ tablets 125mg, No. 6

In adults:

treatment of influenza and other acute respiratory viral infections;

treatment of herpes infection.

Prevention of influenza and other acute respiratory viral infections in adults.

Tiloron-SZ is taken orally, after meals.

For the treatment of influenza and other acute respiratory viral infections - 125 mg / day for the first 2 days of treatment, then 125 mg after 48 hours. For the course - 750 mg (6 tablets).

For the prevention of influenza and other acute respiratory viral infections - 125 mg once a week for 6 weeks. For the course - 750 mg (6 tablets).

For the treatment of herpes infection - the first two days for 125 mg, then after 48 hours for 125 mg. Heading dose - 1.25-2.5 g (10-20 tablets).

When treating influenza and other acute respiratory viral infections, if the symptoms of the disease persist for more than 4 days, you should consult a doctor.

Orange film-coated tablets, round, biconvex; on a cross-section, the core of the tablet is orange with minor inclusions of white.

1 tab. tilorone dihydrochloride 125 mg

Excipients: microcrystalline cellulose 102 - 105 mg, potato starch - 46 mg, hypromellose (hydroxypropyl methylcellulose) - 4 mg, hyprolose (hydroxypropyl cellulose) - 17 mg, magnesium stearate - 3 mg.

• Hypersensitivity to tilorone or any other component of the drug;

• pregnancy;

• breastfeeding period;

• children under 18 years of age.

pharmachologic effect

Low molecular weight synthetic interferon inducer that stimulates the formation of all types of interferons in the body (alpha, beta, gamma and lambda). The main producers of interferon in response to the administration of tilorone are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral administration, the maximum production of interferon is determined in the sequence intestines - liver - blood after 4-24 hours.

Tilorone has immunomodulatory and antiviral effects.

After a single oral administration of tilorone in a dose equivalent to the maximum daily dose for humans, the maximum concentration in the lung tissue of interferon lambda was determined after 24 hours, interferon alpha - after 48 hours. respiratory viral infections.

In human leukocytes, it induces the synthesis of interferon. Stimulates bone marrow stem cells, depending on the dose, enhances antibody production, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers.

Effective against various viral infections, incl. against influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpes viruses. The mechanism of antiviral action is associated with inhibition of the translation of virus-specific proteins in infected cells, as a result of which the reproduction of viruses is suppressed.

Pharmacokinetics

Absorption and distribution

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability - 60%. About 80% of the drug binds to plasma proteins.

Metabolism and excretion

The drug does not undergo biotransformation and does not accumulate in the body.

It is excreted practically unchanged through the intestines (70%) and by the kidneys (9%). T1 / 2 - 48 h.

Side effect

Perhaps: allergic reactions, dyspeptic symptoms, short-term chills.

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor.

Application during pregnancy and lactation

The drug is contraindicated during pregnancy.

If necessary, the appointment of the drug during lactation should stop breastfeeding.

Application in children

The use of the drug is contraindicated in children under 18 years of age.

special instructions

Influence of ability to drive vehicles and mechanisms

The drug does not adversely affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Overdose

Cases of drug overdose are unknown.

Drug interactions

Compatible with antibiotics and medicines for traditional treatment of viral and bacterial diseases. No clinically significant interaction of tilorone with antibiotics and traditional treatments for viral and bacterial diseases has been identified.