Thermicon cream 1%, 15 g

• prevention and treatment of fungal skin infections, incl. mycoses of the feet (tinea pedis), inguinal epidermophytosis (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis) caused by dermatophytes;

• yeast infections of the skin (mainly caused by Candida albicans), in particular, diaper rash;

• versicolor versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare.

TermikonЃ is prescribed externally for adults and children over 12 years of age.

Before applying the cream, it is necessary to clean and dry the affected areas. The cream is applied 1-2 times / day with a thin layer on the affected skin and adjacent areas, rubbing lightly.

For infections accompanied by diaper rash (under the mammary glands, in the interdigital spaces, between the buttocks, in the groin area), the places where the cream is applied can be covered with gauze, especially at night.

The average duration of treatment for dermatomycosis of the trunk, legs, feet - 1 time / day for 1 week; with candidiasis of the skin - 1-2 times / day for 1-2 weeks; with multi-colored lichen - 1-2 times / day for 2 weeks.

A decrease in the severity of clinical manifestations is usually noted in the first days of treatment. In the case of irregular treatment or premature termination of it, there is a risk of re-infection. If after 1-2 weeks of treatment there are no signs of improvement, the diagnosis should be verified.

The dosage regimen of the drug for elderly patients is the same as for patients of other age groups.

Cream for external use 1% white, homogeneous, with a weak specific odor.

terbinafine hydrochloride

Excipients : benzyl alcohol, cetyl palmitate, sodium hydroxide, sorbitan stearate, stearyl alcohol, cetyl alcohol, polysorbate 60, isopropyl myristate, purified water.

• hypersensitivity to the components of the drug.

The drug should be used with caution in hepatic and / or renal failure, alcoholism, inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities, in children under 12 years of age (lack of sufficient clinical experience).

pharmachologic effect

Antifungal drug for topical use. Possesses a wide spectrum of antifungal action.

Active against dermatophytes: Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum, Microsporum canis, Epidermophyton floccosum. In small concentrations, in addition to dermatophytes, terbinafine has a fungicidal effect against molds, yeasts (mainly Candida albicans) and certain dimorphic fungi (Pityrospomm orbiculare). Activity against yeast fungi, depending on their type, can be fungicidal or fungistatic.

Terbinafine specifically alters the early stage of sterol biosynthesis in fungi. This leads to a deficiency of ergosterol and intracellular accumulation of squalene, which causes the death of the fungal cell. Terbinafine works by inhibiting the enzyme squalene epoxidase located on the cell membrane of the fungus.

ThermikonЃ does not affect the isozymes of the cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs.

Pharmacokinetics

When applied topically, absorption is less than 5%, it has a slight systemic effect.

Indications for ThermikonЃ

• prevention and treatment of fungal skin infections, incl. mycoses of the feet (tinea pedis), inguinal epidermophytosis (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis) caused by dermatophytes;

• yeast infections of the skin (mainly caused by Candida albicans), in particular, diaper rash;

• versicolor versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare.

  Side effect

  Local reactions: in places where the cream is applied, redness, itching or burning sensation, allergic reactions are possible.

  Contraindications for use

  • hypersensitivity to the components of the drug.

  The drug should be used with caution in hepatic and / or renal failure, alcoholism, inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities, in children under 12 years of age (lack of sufficient clinical experience).

  Application during pregnancy and lactation

  So far, no malformations have been reported with the use of Thermicon. However, since the clinical experience of using Thermicon during pregnancy is very limited, it should only be used under strict indications.

  Terbinafine is excreted in breast milk. In the case of a nursing mother using Thermicon, a small amount of the active substance is absorbed through the skin, therefore, an adverse effect on the baby is unlikely.

  In experimental studies, the teratogenic properties of terbinafine have not been identified.

  Application for violations of liver function

  The drug is used with caution in liver failure.

  Application for impaired renal function

  The drug is used with caution in renal failure.

  Application in children

  The drug should be used with caution in children under 12 years of age (lack of sufficient clinical experience).

  Use in elderly patients

  The dosage regimen of the drug for elderly patients is the same as for patients of other age groups.

  special instructions

  A decrease in the severity of clinical manifestations is usually noted in the first days of treatment. In the case of irregular treatment or premature termination of it, there is a risk of recurrence of the infection.

  ThermiconЃ is intended for external use only.

  Avoid contact with eyes as it may cause irritation. In case of accidental contact with the eyes, rinse them immediately with running water, and in case of persistent irritation, consult a doctor.

  With the development of allergic reactions, it is necessary to cancel the drug.

  Overdose

  No cases of drug overdose have been reported. If TermikonЃ is accidentally taken orally, you can expect the development of the same symptoms as with an overdose of tablets: headache, nausea, epigastric pain and dizziness.

  Treatment: activated carbon, if necessary, symptomatic supportive therapy.

  Drug interactions

  There are no data on drug interactions for Thermicon.