Tantum Verde solution for topical application 0.15%, 500ml

Inflammatory diseases of the oral cavity and ENT organs (of various etiologies):

- gingivitis, glossitis, stomatitis (including after radiation and chemotherapy);

-angina, pharyngitis, laryngitis, tonsillitis;

- candidiasis (as part of combination therapy);

-calculous inflammation of the salivary glands;

-after surgical interventions and injuries (tonsillectomy, jaw fractures, etc.);

-after treatment or tooth extraction;

- periodontal disease.

- For infectious and inflammatory diseases requiring systemic treatment, it is necessary to use TantumЃ Verde as part of a combination therapy.

The drug is used topically after meals. After rinsing, spit out the solution. If a burning sensation occurs when using an undiluted solution, the solution should be diluted (add 15 ml of water to a measuring cup for dilution).

Adults (including elderly patients) and children from 12 years old use 15 ml of the drug (measuring cup included) 2-3 times / day to rinse the throat or mouth cavity.

Do not exceed the recommended dose.

The duration of treatment should not exceed 7 days. If after treatment within 7 days there is no improvement or new symptoms appear, the patient should consult a doctor.

Solution for topical application 0.15% transparent, green in color, with a characteristic mint odor.

100 ml

benzydamine hydrochloride 0.15 g

Excipients: ethanol 96% - 8 g, glycerol (glycerin) - 5 g, methyl parahydroxybenzoate - 0.1 g, menthol flavor - 0.03 g, saccharin - 0.024 g, sodium bicarbonate - 0.011 g, polysorbate 20 - 0.005 g, quinoline yellow dye 70 % (E104) - 0.0016 g, patented blue dye 85% (E131) - 0.00033 g, purified water - qs up to 100 ml.

• Children under 12 years of age;

• hypersensitivity to benzydamine or other components of the drug.

  The drug should be used with caution in case of hypersensitivity to acetylsalicylic acid or other NSAIDs; bronchial asthma (including history).

pharmachologic effect

NSAIDs for topical use, belongs to the indazole group. It has anti-inflammatory and local analgesic effects. Has an antiseptic effect against a wide range of microorganisms.

The mechanism of action of the drug is associated with the stabilization of cell membranes and inhibition of prostaglandin synthesis.

Benzydamine has an antibacterial effect due to the rapid penetration of microorganisms through the membranes with subsequent damage to cellular structures, disruption of metabolic processes and cell lysosomes.

Has antifungal activity against Candida albicans. It causes structural modifications of the cell wall of fungi and metabolic chains, and thus interferes with their reproduction. This property was the basis for the use of benzydamine in inflammatory processes in the oral cavity, incl. infectious etiology.

Pharmacokinetics

When applied topically, the drug is well absorbed through the mucous membranes and penetrates into the inflamed tissues, is found in the blood plasma in an amount insufficient to obtain systemic effects.

Benzydamine is excreted mainly by the kidneys in the form of inactive metabolites or conjugation products.

Side effect

In each group, adverse effects are presented in order of decreasing severity.

Local reactions: rarely - dry mouth, burning sensation in the mouth; frequency unknown - feeling of numbness in the mouth.

Allergic reactions: infrequently - photosensitivity; rarely - hypersensitivity reactions, skin rash, pruritus; very rarely - angioedema, laryngospasm; frequency unknown - anaphylactic reactions.

If any of the side effects indicated in the instructions are aggravated or any other side effects not indicated in the instructions are noted, the patient should immediately inform the doctor about it.

Application during pregnancy and lactation

The drug TantumЃ Verde should not be used during pregnancy and during breastfeeding.

Application in children

The drug is contraindicated in children under 12 years of age.

Use in elderly patients

According to indications.

special instructions

If, when using the solution, a burning sensation arises, the solution should be pre-diluted with water 2 times by bringing the water level to the lines in a graduated glass.

When using TantumЃ Verde, hypersensitivity reactions may develop. In this case, it is recommended to stop treatment and consult a doctor to prescribe appropriate therapy.

In a limited number of patients, the presence of sores in the throat and mouth may indicate a more serious pathology. If symptoms persist for more than 3 days, the patient should consult a doctor.

The use of TantumЃ Verde is not recommended in patients with hypersensitivity to acetylsalicylic acid or other NSAIDs.

TantumЃ Verde should be used with caution in patients with a history of bronchial asthma, because possible development of bronchospasm while taking the drug.

TantumЃ Verde contains parahydroxybenzoates, which can cause allergic reactions.

When using preparations containing ethanol, the results of anti-doping tests for the maximum allowable content of ethanol in the blood, according to the norms established by some sports federations, may be positive.

Drivers of vehicles should keep in mind that the drug contains ethanol (1 dose of the drug (15 ml) contains 1.2 g of 96% alcohol).

Influence on the ability to drive vehicles and mechanisms

The drug does not affect the ability to drive vehicles and work with mechanisms.

Overdose

Currently, no cases of overdose of TantumЃ Verde have been reported. When using the drug in accordance with the instructions, an overdose is unlikely.

Symptoms: if the drug is accidentally swallowed, the following symptoms are possible - vomiting, abdominal cramps, anxiety, fear, hallucinations, convulsions, ataxia, fever, tachycardia, respiratory depression.

Treatment: carrying out symptomatic therapy; induce vomiting or gastric lavage using a gastric tube (under medical supervision); it is necessary to provide medical supervision, supportive therapy and the necessary hydration. The antidote is unknown.

Drug interactions

Interaction studies with other medicinal products have not been conducted.