Syntomycin liniment 10%, 25g

Infected wounds in the second phase of the wound process (absence of pus, necrotic tissue), long-term non-healing trophic ulcers, 2-3 degree burns.

Outwardly. After the treatment of the wound or burn surface, liniment is applied and a sterile bandage is applied on top in combination (or without) with parchment or compress paper; when treating wounds, the dressing is changed once a day, when treating burns - every day or 2-3 times a week. In the treatment of infectious skin diseases, liniment is applied to the lesions 1-2 times a day.

Tampons with liniment are loosely filled with the cavities of purulent wounds after their surgical treatment, and gauze turundas with the drug are injected into the fistulous passages.

The duration of treatment is determined by the dynamics of cleansing and healing of lesions.

If after treatment there is no improvement or symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications and the method of use indicated in the instructions for use.

per 100 g of liniment:

Active ingredient: Chloramphenicol [DL] (Syntomycin) - 10 g;

Excipients: castor oil - 20.0 g; emulsifier No. 1 - 5.0 g; sorbic acid - 0.2 g; carmellose sodium - 2.0 g; purified water - up to 100.0 g.

Individual hypersensitivity to chloramphenicol or to drug components, skin diseases (psoriasis, eczema, fungal lesions), phase I of the wound process (due to lack of osmotic activity), inhibition of bone marrow hematopoiesis, acute intermittent porphyria. deficiency of glucose-6-phosphate dehydrogenase, liver failure, renal failure, pregnancy, breastfeeding period, neonatal period (up to 4 weeks).

Carefully

children's age from 4 weeks to 3 years.

Trade name:

Synthomycin

International non-proprietary or group name:

chloramphenicol [D, L]

Dosage form:

liniment for outdoor use

Composition for 100 g of liniment:

Active ingredient: Chloramphenicol [DL] (Syntomycin) - 10 g;

Excipients: castor oil - 20.0 g; emulsifier No. 1 - 5.0 g; sorbic acid - 0.2 g; carmellose sodium - 2.0 g; purified water - up to 100.0 g.

Description:

liniment of white or slightly yellowish color, with a weak peculiar smell.

Pharmacotherapeutic group:

antibiotic.

Pharmacological properties

Pharmacodynamics

The mechanism of action of chloramphenicol is due to a violation of protein synthesis in a bacterial cell due to inhibition of peptidyl transferase. Acts bacteriostatically. The drug has a wide spectrum of action against gram-positive, gram-negative, aerobic and anaerobic microflora: staphylococci, streptococci, Escherichia coli, Pseudomonas aeruginosa, Proteus, Clostridia, peptostreptococci, etc., including hospital strains of bacteria with increased resistance to other antibiotics. Drug resistance develops slowly and usually there is no cross-tolerance to other chemotherapeutic agents

Pharmacokinetics

When applied externally, its absorption is negligible.

Indications for use

Infected wounds in the second phase of the wound process (absence of pus, necrotic tissue), long-term non-healing trophic ulcers, 2-3 degree burns.

Contraindications

Individual hypersensitivity to chloramphenicol or to drug components, skin diseases (psoriasis, eczema, fungal lesions), phase I of the wound process (due to lack of osmotic activity), inhibition of bone marrow hematopoiesis, acute intermittent porphyria. deficiency of glucose-6-phosphate dehydrogenase, liver failure, renal failure, pregnancy, breastfeeding period, neonatal period (up to 4 weeks).

Carefully

children's age from 4 weeks to 3 years.

Application during pregnancy and during breastfeeding

The drug is contraindicated.

Method of administration and dosage

Outwardly. After the treatment of the wound or burn surface, liniment is applied and a sterile bandage is applied on top in combination (or without) with parchment or compress paper; when treating wounds, the dressing is changed once a day, when treating burns - every day or 2-3 times a week. In the treatment of infectious skin diseases, liniment is applied to the lesions 1-2 times a day.

Tampons with liniment are loosely filled with the cavities of purulent wounds after their surgical treatment, and gauze turundas with the drug are injected into the fistulous passages.

The duration of treatment is determined by the dynamics of cleansing and healing of lesions.

If after treatment there is no improvement or symptoms worsen, or new symptoms appear, you should consult your doctor. Use the drug only according to the indications and the method of use indicated in the instructions for use.

Side effect

Itching, redness or dryness of the treated skin area, skin-allergic reactions, angioedema.

From the side of hematopoiesis: reticulocytopenia, leukopenia, granulocytopenia. thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis.

If these effects occur, the drug should be discontinued.

If any of the side effects indicated in the instructions are aggravated, or any other side effects not indicated in the instructions are noted, you should immediately inform your doctor about it.

Overdose

To date, there have been no reports of overdose cases when using the drug.

Interaction

Has not been studied.

special instructions

In the course of treatment, systematic monitoring of the peripheral blood picture is necessary.

When applied to large surfaces with the simultaneous intake of ethanol, disulfiram-like reactions may develop (hyperemia of the skin, tachycardia, nausea, vomiting, reflex cough, convulsions).

Influence on the ability to drive vehicles and other mechanisms

Has not been studied.

Release form

Liniment for external use 10%.

25 g, 50 g or 100 g of the drug in an aluminum tube or in a tube made of a combined material for packaging medicines. 25 g in a glass jar for storing medicines, type BTS, with a triangular rim, sealed with a lid stretched with a sealing element.

Each tube or jar, together with instructions for use, is placed in a cardboard box.

20 cans are placed in a cardboard box, with instructions for medical use attached in an amount corresponding to the number of cans (for hospitals).

Shelf life

2 years. Do not use after the expiration date.

Storage conditions

In a dark place at a temperature not exceeding 20 ? C. Keep out of the reach of children.

Vacation conditions

Available without a prescription.