Suprilamin tablets 25mg, no. 30

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BIDL3177713
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Expiration Date: 05/2027

Russian Pharmacy name:

Суприламин таблетки 25мг, №30

Suprilamin tablets 25mg, no. 30

  • Allergic diseases, incl. urticaria, serum sickness, angioedema, hay fever (hay fever), allergic rhinopathies, allergic conjunctivitis.

  • Skin diseases, incl. contact dermatitis, acute and chronic eczema, drug rashes, itchy dermatoses.

  • Itching with insect bites.

When taken orally for adults - 25 mg 3-4 times / day, for children, depending on age - 6.25-12.5 mg 2-3 times / day. The maximum dose for adults is 150 mg / day.

Tablets are white or almost white, round, flat-cylindrical, odorless or almost odorless, with a cross-shaped line on one side and bevels on both sides.

1 tab.

chloropyramine hydrochloride 25 mg

Excipients: lactose monohydrate (milk sugar), microcrystalline cellulose, sodium carboxymethyl starch (sodium starch glycolate, primogel), povidone K25 (kollidon K25), magnesium stearate.

  • Glaucoma (for parenteral administration),

  • benign prostatic hyperplasia,

  • urinary retention (for parenteral administration),

  • simultaneous administration of MAO inhibitors (for parenteral administration),

  • peptic ulcer in the acute phase (for parenteral administration),

  • acute attack of bronchial asthma,

  • pregnancy,

  • lactation period,

  • early childhood up to 1 month,

  • hypersensitivity to chloropyramine or other ethylenediamine derivatives.

pharmachologic effect

A blocker of histamine H1 receptors, a derivative of ethylenediamine. It has anti-allergic and antipruritic effects. Causes sedation. Possesses peripheral anticholinergic activity, moderate antispasmodic properties.

Pharmacokinetics

After oral administration, chloropyramine hydrochloride is rapidly and completely absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved within the first 1-2 hours, the therapeutic level of concentration is maintained for 3-6 hours. Regardless of the route of administration, it is well distributed in the body, including the central nervous system. Plasma protein binding of chloropyramine is 7.9%. The binding peak is noted at pH 7.4. It is metabolized in the liver. It is introduced mainly by the kidneys in the form of metabolites. In children, elimination is faster than in adults. Side effect From the side of the central nervous system: lethargy, drowsiness, weakness, slight tremor, dizziness are possible. In children, some stimulating effect on the central nervous system is possible, manifested by anxiety, increased irritability, and insomnia. From the digestive system: possible dry mouth, nausea, vomiting, diarrhea or constipation.From the side of the cardiovascular system: rarely - lowering blood pressure (more often in elderly patients), tachycardia, arrhythmia. Allergic reactions: possible skin rash, itching. Others: rarely - difficulty urinating.

Application during pregnancy and lactation

Contraindicated during pregnancy and lactation.

Application for violations of liver function

It should be used with caution in case of liver failure.

Application in children

Contraindicated in early childhood up to 1 month. Use with caution in children due to the increased sensitivity of this category of patients to antihistamines.

Use in elderly patients

It should be used with caution in elderly patients.

special instructions

It should be used with caution in elderly patients, with liver failure and / or heart disease. Use with caution in children due to the increased sensitivity of this category of patients to antihistamines. With extreme caution, it should be used orally in patients with angle-closure glaucoma, urinary retention and prostatic hypertrophy. When taken at night, chloropyramine may exacerbate the symptoms of reflux esophagitis. During treatment, alcohol should be avoided.

Influence on the ability to drive vehicles and use mechanisms

In the initial, individually determined period of chloropyramine use, driving of vehicles and engaging in other potentially hazardous activities that require the speed of psychomotor reactions are not allowed. In the course of further treatment, the degree of restrictions is determined depending on the tolerance of the treatment.

Drug interactions

With the simultaneous use of chloropyramine potentiates the effects of anesthetics, hypnotics, tranquilizers, analgesics, MAO inhibitors, tricyclic antidepressants, atropine and sympatholytics (this combination requires caution). With the simultaneous use of chloropyramine and caffeine or phenamine, there is a decrease or elimination of the inhibitory effect of chloropyramine on the central nervous system.

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