Sulpiride tablets 200mg, No. 30

• Neurotic conditions, accompanied by lethargy; psychosomatic disorders, incl. with gastric ulcer and duodenal ulcer, NUC;

• acute and chronic psychoses with a predominance of lethargy, agrammatism, abulia;

• acute and chronic psychoses, accompanied by delirium or confusion, incl. with schizophrenia.

Inside for adults - 100-300 mg / day in 2-3 doses.

Tablets 1 tab.

sulpiride

• Pheochromocytoma

• arterial hypertension,

• psychomotor agitation,

• hypersensitivity to sulpiride.

pharmachologic effect

An antipsychotic agent (neuroleptic) from the group of substituted benzamides. It has a mild antipsychotic and antidepressant effect in combination with an activating effect. The mechanism of antipsychotic action is associated with the selective blockade of central dopamine D2 receptors. The sedative effect is weak, the alpha-adrenergic blocking activity is low, practically does not cause antimuscarinic effects. Rarely causes extrapyramidal disorders, therefore it belongs to the 'atypical' antipsychotics. Promotes healing of ulcerative lesions of the stomach and duodenum.

Pharmacokinetics

After intramuscular injection of sulpiride at a dose of 100 mg, Cmax in plasma is reached after 30 minutes, after oral administration at a dose of 200 mg - after 4.5 hours. Oral bioavailability is 25-35% and is characterized by significant individual variability.

The concentration of sulpiride in plasma is proportional to the dose.

Plasma protein binding is no more than 40%. Sulpiride quickly penetrates into all body tissues, faster - into the liver and kidneys, more slowly - into the brain tissue (with the main amount accumulating in the pituitary gland). 0.1% of the daily dose of sulpiride is excreted in breast milk.

It is excreted by the kidneys unchanged by glomerular filtration (92%). Total clearance (usually equal to renal clearance) is 126 ml / min. T1 / 2 - about 7 hours

Side effect

From the side of the central nervous system: agitation, dizziness, sleep disorders, oral automatism, aphasia.

From the digestive system: dry mouth, heartburn, vomiting, constipation.

From the side of the cardiovascular system: increased blood pressure.

From the endocrine system: menstrual irregularities, decreased sexual activity. With long-term use in high doses - galactorrhea, gynecomastia.

Allergic reactions: skin rash, itching.

Application during pregnancy and lactation

During pregnancy and lactation, use with caution and in the lowest effective doses.

Application for impaired renal function

For severe renal impairment, dose reduction or intermittent treatment is recommended

Application in children

Use with caution in children.

Use in elderly patients

Use with caution in the elderly.

special instructions

Use with caution in patients with parkinsonism, the elderly. In severe renal failure, dose reduction or intermittent treatment is recommended.

In patients with epilepsy, before starting therapy, it is necessary to conduct a preliminary clinical and electrophysiological examination, because sulpiride lowers the threshold of convulsive readiness.

In the event of hyperthermia, which is one of the elements of the NNS, sulpiride should be discontinued immediately.

Avoid drinking alcohol during treatment.

Use with caution in children.

Influence on the ability to drive vehicles and use mechanisms

During the period of treatment, one should refrain from engaging in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Drug interactions

With the simultaneous use of drugs that depress the central nervous system (opioid analgesics, hypnotics, tranquilizers, clonidine, central antitussives), the inhibitory effect on the central nervous system is enhanced.

With simultaneous use with antihypertensive drugs, the antihypertensive effect increases and the risk of orthostatic hypotension increases.

With simultaneous use with levodopa, the effectiveness of sulpiride decreases.

Cases of the development of severe extrapyramidal reactions with the simultaneous use of sulpiride with lithium carbonate are described.

With simultaneous use with fluoxetine, the development of extrapyramidal symptoms and dystonia is possible.