Sulgin Avexima tablets 500mg, No. 10

• bacterial dysentery;

• colitis and enterocolitis;

• preparation for colon surgery.

In acute dysentery, 2 courses of treatment are carried out. The first course: on days 1 and 2 - 1 g every 4 hours (total 6 g / day), 3 and 4 days - 1 g every 6 hours (4 g / day), 5 and 6 days - 1 g every 8 hours ( 3 g / day). If necessary, after 5-6 days, a second course is carried out: 1 and 2 days - 1 g every 4 hours, at night - after 8 hours (total 5 g / day), 3 and 4 days - 1 g after 4 hours (4 g / day), do not give at night, 5 day - 3 g / day.

Children over 3 years old - 0.5 g 4 times / day for 7 days.

In the treatment of other infections: for adults - by mouth, 1-2 g every 4-6 hours; in the next 2-3 days - half doses.

Children over 3 years old - on the first day, 0.1 g / kg / day in equal doses every 4 hours, on the following days - 0.25-0.5 g every 6-8 hours.

For the prevention of postoperative intestinal complications - 0.05 g / kg every 8 hours, for 5 days before and 7 days after surgery.

Higher doses for adults: single - 2 g, daily - 7 g.

Tablets are white, flat-cylindrical, chamfered and scored.

1 tab.

sulfaguanidine monohydrate 500 mg

Excipients: potato starch - 90 mg, calcium stearate - 4 mg, sodium carboxymethyl starch - 6 mg.

• hypersensitivity to the components of the drug or other sulfonamides;

• deficiency of glucose-6-phosphate dehydrogenase;

• nephrourolithiasis;

• porphyria;

• B12 deficiency anemia;

• pregnancy;

• lactation period;

• children under 3 years old;

• hyperbilirubinemia (in children).

pharmachologic effect

Antimicrobial bacteriostatic agent. The mechanism of action is due to antagonism with para-aminobenzoic acid (PABA) and competitive inhibition of dihydropteroate synthetase, which leads to a violation of the synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines. Inhibits the growth of Escherichia coli and reduces the synthesis of thiamine, riboflavin, niacin in the intestine. Sulgin Avexima has a bacteriostatic effect on Streptococcus spp., Staphylococcus spp., Escherichia coli, Shigella dysenteriae, Proteus vulgaris.

Pharmacokinetics

After oral administration, the drug is slightly absorbed from the digestive tract, resulting in a high bacteriostatic concentration in the intestine.

Side effect

From the digestive system: nausea, vomiting.

From the urinary system: crystalluria.

Allergic reactions: urticaria, exfoliative dermatitis.

Others: hypovitaminosis B, leukopenia, neuritis.

Application in children

It is forbidden to use the drug in children under the age of 3 years.

In acute dysentery, children over 3 years old - 0.5 g 4 times / day for 7 days.

When treating other infections: children over 3 years old - on the first day, 0.1 g / kg / day in equal doses every 4 hours, on the following days - 0.25-0.5 g every 6-8 hours.

special instructions

In order to prevent crystalluria during the treatment period, patients should receive an abundant drink (2-3 l / day).

Early discontinuation of treatment or insufficient doses can lead to the emergence of resistant strains of pathogens.

During the treatment period, it is recommended to take B vitamins.

Overdose

There is no information on overdose.

Drug interactions

Reduces the reliability of oral contraception.

Benzocaine, procaine reduce the antimicrobial activity (PABA is released during hydrolysis).

Non-steroidal anti-inflammatory drugs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and indirect anticoagulants increase the severity of side effects of the drug.

Ascorbic acid, hexamethylenetetramine increase the risk of crystalluria.

Myelotoxic drugs increase the manifestations of the drug's hematotoxicity.