Sulfetrisan injection 100ml
DESCRIPTION
Sulfetrisan is a broad spectrum antimicrobial agent for animals. In appearance it is a clear solution for injection. Packaged in 100 ml bottles, which are packed in cardboard boxes.
COMPOSITION
1 ml of solution contains 200 mg of sulfadimethoxine, 50 mg of erythromycin thiocyanate, 18 mg of trimethoprim, 0.1 mg of dexamethasone and auxiliary components: benzocaine, sodium hydroxide, dimethylacetamide, dimethylformamide, dimethylsulfoxide, propylene glycol and distilled water.
PHARMACOLOGICAL PROPERTIES
Sulfetrisan is a long-acting antimicrobial drug, due to the combination of an antibiotic, an anti-inflammatory glucocorticosteroid and sulfonamide, the spectrum of its antimicrobial action expands and resistance to the drug develops more slowly. Sulfetrisan is effective against Staphylococcus spp., Streptococcus spp., Escherichia coli, Shigella spp., Salmonella spp., Pasteurella spp., Clostridium spp., Haemophilus spp., Corynebacterium spp., Campylobacter spp., Klebstogenella spp., Klebstogenella spp., Klebstogenella spp, as well as chlamydia and treponema.
Erythromycin is a macrolide antibiotic of bacteriostatic action, it blocks protein synthesis and disrupts the formation of peptide bonds between amino acid molecules in a microbial cell. The mechanism of action of trimethoprim and sulfadiazine is due to a double blocking effect on the metabolism of bacteria through competitive antagonism. Sulfadimethoxine is similar in its chemical structure to para-aminobenzoic acid (PABA) and is captured by the microbial cell, preventing it from being incorporated into the dihydrofolic acid molecule. Trimethoprim reversibly inhibits bacterial dihydrofolate reductase, disrupts the synthesis of tetrahydrofolic acid from dihydrofolic acid, the formation of purine and pyrimidine bases, nucleic acids, thereby inhibiting the growth and reproduction of microorganisms.
Dexamethasone is a glucocorticosteroid that has a pronounced anti-inflammatory, desensitizing, anti-allergic effect by inhibiting the release of inflammatory mediators. Dexamethasone reduces the number of mast cells that produce hyaluronic acid, reduces the porosity of blood capillaries, and stimulates the biosynthesis of lipocartins (special proteins) that have anti-edematous activity. With parenteral administration, the active components of the drug are sufficiently well and quickly absorbed from the injection site. Erythromycin crosses the hematoplacental barrier and is excreted from the body along with bile and about 15% in urine. Sulfadimethoxine, trimethoprim, dexamethasone are excreted mainly in the urine. According to the degree of influence on the body of warm-blooded animals, the drug belongs to moderately hazardous substances.
INDICATIONS
Prescribed to large and small ruminants, pigs, dogs and cats for the treatment of infectious diseases of the digestive, respiratory and genitourinary systems, including pasteurellosis, colibacillosis, enzootic pneumonia, edema of piglets and other primary and secondary infections of bacterial etiology, the causative agents of which are sensitive to erythromycin and sulfonamides.
DOSES AND METHOD OF APPLICATION
Sulfetrisan is administered to animals deeply intramuscularly in compliance with the rules of asepsis and antiseptics with an interval of 12 to 24 hours between injections for 3 to 5 days, depending on the severity of the disease.
Cattle are administered at the rate of 20-30 ml per animal, calves - 5-10 ml per animal; pigs, small ruminants, dogs and cats - 1 ml per 5 - 10 kg of animal weight.
The maximum volume of Sulfetrisan for injection at one point should not exceed: for cattle - 20 ml, for pigs, calves and small ruminants - 10 ml, for piglets - 5 ml, for dogs and cats - 2.5 ml. If the next injection of the drug is missed, Sulfetrisan should be administered to the animal as soon as possible, but the dose of the drug should not be doubled and the required interval between injections should be observed according to the treatment regimen.
SIDE EFFECTS
In animals with increased individual sensitivity (especially in goats), allergic reactions and other signs of drug intolerance may be observed. In these cases, the drug is discontinued and symptomatic treatment is prescribed. At the first use of the drug, in rare cases, animals may experience depression, a slight rise in body temperature. Skin irritation and soreness may occur at the injection site, which quickly pass and do not require treatment. In case of an overdose of Sulfetrisan, animals develop lethargy, itching, depression, refusal to feed, nausea, trembling, jaundice, body temperature may rise, cyanosis of mucous membranes and skin may be observed. In these cases, the drug is stopped, symptomatic treatment is prescribed, detoxification is carried out using solutions,
CONTRAINDICATIONS
Individual hypersensitivity to drug components. It is not recommended for use in animals suffering from renal and hepatic insufficiency, as well as having a history of deficiency of the enzyme glucose-6-phosphate dehydrogenase. Sulfetrisan is not prescribed with PABA derivatives, anticoagulants and hypoglycemic sulfanilurease, do not mix in the same syringe with other injectable drugs.
FEATURES
With caution, under the supervision of a veterinarian, treatment is carried out in goats in view of the increased species sensitivity to the components of the drug.
Slaughter of animals for meat is allowed no earlier than 5 days after the last use of the drug. The meat of animals that were forcedly killed before the expiration of the specified period can be used to feed fur animals or for the production of meat and bone meal. Milk must not be used for food purposes within 3 days after the last use of the drug. The milk obtained earlier than the established period can be used after boiling in animal feed.
In case of accidental contact of the drug on the skin, wash it off immediately with a stream of running water. If Sulfetrisan is accidentally swallowed, saline, castor or vaseline oil, spirulina, cholican are applied to a person. If the condition worsens, you should immediately contact a medical institution.
STORAGE AND SHELF LIFE
Store in a dry place, protected from direct sunlight and out of reach of children and animals, separately from food and feed at temperatures from 5 to 25 В° C. The shelf life is 3 years. Opened vials can be stored for no more than 28 days. During storage, the drug can turn into a jelly-like state, which does not affect its pharmacological properties and effectiveness. In this case, the bottle with the drug is carefully warmed up to 45 - 50 В° C in a water bath until completely dissolved.
Specifications
KolVUP
ten
Manufacturer
APICENNA
Temperature regime
from +5 to +25
Teaser
for the treatment of infectious diseases of the digestive, respiratory and genitourinary system, including pasteurellosis, colibacillosis, enzootic pneumonia, edema of piglets and other primary and secondary infections of bacterial etiology