Subetta tablets d / rassas., No. 100

Subetta is indicated for use in adults.

• type 1 diabetes mellitus (as an adjunct to basic bolus insulin therapy);

• type 2 diabetes mellitus (as part of complex therapy).

Inside. At one time - 1 tablet (keep in the mouth until it is completely dissolved, not during a meal). The tablet should be kept in the mouth, without swallowing, until it is completely dissolved. The frequency of administration is set by the doctor and can vary from 2 to 4 times / day, depending on the degree of diabetes compensation.

Lozenges from white to almost white, flat-cylindrical shape, with a score and a bevel; the flat side with scribble has the inscription MATERIA MEDICA, the other flat side has the inscription SUBETTA.

1 tab.

antibodies to the C-terminal fragment of the beta subunit of the insulin receptor affinity purified 0.006 g *

antibodies to endothelial NO synthase affinity purified 0.006 g *

* applied to isomalt in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted 10012, 10030, 100200 times, respectively.

Excipients: isomalt, crospovidone, magnesium stearate.

• Age under 18;

• increased individual sensitivity to the components of the drug.

pharmachologic effect

Antibodies to the C-terminal fragment of the ?-subunit through the mechanisms of allosteric modulation sensitize the insulin receptor, increase its sensitivity to both endogenous and injected insulin, which is accompanied by activation of the metabolism of insulin-dependent glucose. It has been experimentally shown that antibodies to the ?-subunit have a moderately pronounced hypoglycemic effect (decrease in fasting glycemia by 0.7-1.4 mmol / L), while long-term use was not accompanied by the development of such side effects as hypoglycemia, acidosis, increased body weight, hemostasis disorders, and hematopoiesis. Antibodies to endothelial NO-synthase increase the activity of endothelial NO-synthase, which is accompanied by an increase in the content of NO, which has an endothelioprotective effect, contributes to a decrease in vascular reactivity, a decrease in vascular spasm,normalization of blood pressure and improvement of peripheral microcirculation. Antibodies to endothelial NO-synthase have a moderately pronounced psychotropic effect in the form of anti-anxiety, antiasthenic, vegetative-stabilizing effects. With the combined use of the components in the composition of the complex drug Subetta, a synergistic effect on the sensitivity of somatic cells to insulin is observed - due to the nonspecific NO-dependent activation of intracellular signal transduction from the insulin receptor, which makes it possible to increase the effectiveness of insulin therapy, stabilize the doses used and reduce the risk of side effects. The drug reduces the severity of complications of diabetes: cardiovascular disorders, neuropathies, nephropathies.Antibodies to endothelial NO-synthase have a moderately pronounced psychotropic effect in the form of anti-anxiety, antiasthenic, vegetative-stabilizing effects. With the combined use of the components in the complex drug Subetta, a synergistic effect on the sensitivity of somatic cells to insulin is observed - due to the nonspecific NO-dependent activation of intracellular signal transduction from the insulin receptor, which makes it possible to increase the effectiveness of insulin therapy, stabilize the doses used and reduce the risk of side effects. The drug reduces the severity of diabetes complications: cardiovascular disorders, neuropathies, nephropathies.Antibodies to endothelial NO-synthase have a moderately pronounced psychotropic effect in the form of anti-anxiety, antiasthenic, vegetative-stabilizing effects. With the combined use of the components in the complex preparation Subetta, a synergistic effect on the sensitivity of somatic cells to insulin is observed - due to the nonspecific NO-dependent activation of intracellular signal transduction from the insulin receptor, which makes it possible to increase the effectiveness of insulin therapy, stabilize the doses used and reduce the risk of side effects. The drug reduces the severity of complications of diabetes: cardiovascular disorders, neuropathies, nephropathies.With the combined use of the components in the complex preparation Subetta, a synergistic effect on the sensitivity of somatic cells to insulin is observed - due to the nonspecific NO-dependent activation of intracellular signal transduction from the insulin receptor, which makes it possible to increase the effectiveness of insulin therapy, stabilize the doses used and reduce the risk of side effects. The drug reduces the severity of diabetes complications: cardiovascular disorders, neuropathies, nephropathies.With the combined use of the components in the complex drug Subetta, a synergistic effect on the sensitivity of somatic cells to insulin is observed - due to the nonspecific NO-dependent activation of intracellular signal transduction from the insulin receptor, which makes it possible to increase the effectiveness of insulin therapy, stabilize the doses used and reduce the risk of side effects. The drug reduces the severity of complications of diabetes: cardiovascular disorders, neuropathies, nephropathies.The drug reduces the severity of diabetes complications: cardiovascular disorders, neuropathies, nephropathies.The drug reduces the severity of diabetes complications: cardiovascular disorders, neuropathies, nephropathies.

Pharmacokinetics

The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry) does not allow assessing the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of Subetta.

Side effect

Possible reactions of increased individual sensitivity to the components of the drug.

special instructions

Influence on the ability to drive vehicles and control mechanisms Subetta does not affect the ability to drive vehicles and other potentially dangerous mechanisms.

Overdose

In case of an accidental overdose, dyspeptic symptoms are possible due to the fillers included in the drug.

Drug interactions

No cases of incompatibility with other drugs have been registered to date.