Streptomycin sulfate 1g
DESCRIPTION
Streptomycin sulfate for injection (Streptomycini sulfas pro injectionibus) solution for the treatment of animals with diseases of bacterial etiology. In appearance, the drug is a powder.
COMPOSITION
The preparation is a salt of an organic base produced by the microscopic radiant fungus Streptomyces globisporus streptomycini.
PHARMACOLOGICAL PROPERTIES
Streptomycin has bacteriostatic and bactericidal action against many gram-positive and gram-negative pathogenic microbes. The antimicrobial activity of streptomycin is associated with inhibition of protein synthesis at the level of ribosomes in a microbial cell. Streptomycin is not effective against infections caused by Clostridia and other anaerobic microorganisms, plasmodia, fungi, rickettsia, and viruses. Some microorganisms develop resistance to streptomycin, and multiplying microbes can develop antibiotic resistance within a few days. Resistant strains mostly develop by the end of the second month of treatment, but can develop within a few days.
When streptomycin sulfate is administered orally, it is practically not absorbed by the mucous membrane of the gastrointestinal tract and is almost completely excreted through the intestine. When administered intramuscularly, it is rapidly absorbed into the blood and is found in the peritoneal and pleural cavities, in the vitreous body of the eye, in bile, in urine. In the pleural cavity, especially in acute inflammatory processes, the concentration of the antibiotic can reach up to 50% of the level in the blood.
With meningitis, streptomycin enters the spinal canal in large quantities of 10 to 50% of the blood level. It easily crosses the placenta. With normal liver function, streptomycin in high concentrations accumulates in the bile of the hepatic tubules. In case of impaired liver function, it enters the bile in small quantities; with cholecystitis, the content of streptomycin in the gallbladder is 70 - 80% of its level in the blood. The therapeutic concentration in various organs and tissues of the body is maintained for 8 - 12 hours. Streptomycin is rapidly excreted from the body: 50 - 60% - in the urine within 12 - 24 hours. In case of impaired renal excretory function, the excretion of streptomycin slows down.
INDICATIONS
Leptospirosis, tularemia, pneumonia, diplococcal infections, mastitis, endometritis, endocarditis, meningitis, wound and postpartum sepsis, erysipelas and swine edema, malignant catarrhal fever, campylobacteriosis and actinomycosis in cattle and other diseases, the causative agents of which are susceptible to streptococcal infections.
DOSES AND METHOD OF APPLICATION
Immediately before use, the drug is dissolved in sterile water, saline or 0.25 - 0.5% solution of novocaine at the rate of 0.25 g of streptomycin per 1 ml of solvent (0.5 g in 2.5 ml, and 1 g in 5 ml ); more concentrated solutions are painful; glucose solutions are not used as a solvent.
The prepared solution can be stored for 7 days at room temperature, but better in the refrigerator.
A solution of streptomycin sulfate is administered mainly intramuscularly, it is also used topically, internally, externally, intratracheally, intracavitary, intravenous, intraperitoneal, intrauterine. Intramuscular injections are made deep into the muscle. Treatment is carried out within 4 to 7 days. The drug is administered 2 times a day at intervals of 12 hours in the following doses:
Animal species Single dose (mg / kg of animal weight)
adults young
Cattle 3 five
Horses 4 6
Small ruminants, pigs ten 20
Dogs ten 20
Furry animals 25 50
In leptospirosis, streptomycin sulfate is administered for 4 to 10 days at a dose of 25 mg / kg; in severe cases, the dose can be further increased. Streptomycin sulfate can be combined with penicillin, polymyxin, and sulfa drugs. Their combination shows synergistic action and prevents the rapid emergence of resistant forms of pathogens to streptomycin.
SIDE EFFECTS
When administered intramuscularly, cattle sometimes develop rapidly developing allergic reactions (anaphylactic shock, angioedema of the larynx), which can pose a threat to the health of the animal. The occurrence of these complications is associated with the individual characteristics of the animal organism and does not depend on the dose of the administered antibiotic. Complications may appear after the first administration of the drug, but are more often caused by sensitization of the body with repeated courses of treatment. In the event of allergic reactions, animals are injected with norepinephrine, adrenaline, calcium chloride, antihistamines, and corticosteroids. When treating with streptomycin, various toxic reactions, tachycardia, diarrhea, dermatitis, impaired coordination of movement can also be observed, and prolonged use of large doses can develop deafness.
CONTRAINDICATIONS
Hypersensitivity to aminoglycoside antibiotics. Renal and cardiovascular failure. The combined use of streptomycin sulfate with other aminoglycoside drugs (neomycin, kanamycin, monomycin, gentamicin) is not allowed due to a possible increase in nephrotoxic effect.
SPECIAL INSTRUCTIONS
Contact dermatitis may develop in persons who have been in contact with streptomycin for a long time. Some authors do not recommend mixing streptomycin sulfate with penicillin in one syringe, while others are opposed to this combination, while some experts successfully use this combination. Slaughter of animals is allowed 7 days after the last use of the drug. The meat of animals that were forcedly killed earlier than the specified period can be used for the production of meat and bone meal. Milk for food purposes can be consumed 48 hours after the last administration of the drug. Milk obtained earlier than the specified period can be used for feeding animals.
SHELF LIFE AND STORAGE
List B. In a dry, dark place at room temperature. The shelf life is 3 years.
PACKAGING
In a glass bottle of 1 g.
PHARMACOLOGICAL PROPERTIES
Streptomycin has bacteriostatic and bactericidal action against many gram-positive and gram-negative pathogenic microbes. The antimicrobial activity of streptomycin is associated with inhibition of protein synthesis at the level of ribosomes in a microbial cell. Streptomycin is not effective against infections caused by Clostridia and other anaerobic microorganisms, plasmodia, fungi, rickettsia, and viruses. Some microorganisms develop resistance to streptomycin, and multiplying microbes can develop antibiotic resistance within a few days. Resistant strains mostly develop by the end of the second month of treatment, but can develop within a few days.
When streptomycin sulfate is administered orally, it is practically not absorbed by the mucous membrane of the gastrointestinal tract and is almost completely excreted through the intestine. When administered intramuscularly, it is rapidly absorbed into the blood and is found in the peritoneal and pleural cavities, in the vitreous body of the eye, in bile, in urine. In the pleural cavity, especially in acute inflammatory processes, the concentration of the antibiotic can reach up to 50% of the level in the blood.
With meningitis, streptomycin enters the spinal canal in large quantities of 10 to 50% of the blood level. It easily crosses the placenta. With normal liver function, streptomycin in high concentrations accumulates in the bile of the hepatic tubules. In case of impaired liver function, it enters the bile in small quantities; with cholecystitis, the content of streptomycin in the gallbladder is 70 - 80% of its level in the blood. The therapeutic concentration in various organs and tissues of the body is maintained for 8 - 12 hours. Streptomycin is rapidly excreted from the body: 50 - 60% - in the urine within 12 - 24 hours. In case of impaired renal excretory function, the excretion of streptomycin slows down.
INDICATIONS
Leptospirosis, tularemia, pneumonia, diplococcal infections, mastitis, endometritis, endocarditis, meningitis, wound and postpartum sepsis, erysipelas and swine edema, malignant catarrhal fever, campylobacteriosis and actinomycosis in cattle and other diseases, the causative agents of which are susceptible to streptococcal infections.
DOSES AND METHOD OF APPLICATION
Immediately before use, the drug is dissolved in sterile water, saline or 0.25 - 0.5% solution of novocaine at the rate of 0.25 g of streptomycin per 1 ml of solvent (0.5 g in 2.5 ml, and 1 g in 5 ml ); more concentrated solutions are painful; glucose solutions are not used as a solvent.
The prepared solution can be stored for 7 days at room temperature, but l
Specifications
Item segment
Not multiple packaging
KolVUP
50
Manufacturer
BioFarmGarant
Temperature regime
from 0 to +25
Teaser
leptospirosis, tularemia, pneumonia, diplococcal infections, mastitis, endometritis, endocarditis, meningitis, wound and postpartum sepsis, erysipelas and swine edema, malignant catarrhal fever, campylobacteriosis and actinomycosis in cattle, etc.