Solution Vitamin E 30%, 50ml

• Hypovitaminosis E;

• Complex therapy of conditions accompanied by an increased need of the body for vitamin E:

• with muscular dystrophies, dermatomycosis, amyotrophic lateral sclerosis, asthenic and neurasthenic syndromes, fatigue, paresis, myasthenia gravis, myopathies, menstrual irregularities, threatened abortion, menopause, dysfunction of the gonads in men and women;

• with dermatoses, psoriasis;

• with atrophy of the respiratory tract mucosa, periodontal disease;

• with rheumatic diseases: fibrositis, tendopathies, diseases of the joints and spine;

• with endocrine diseases: thyrotoxicosis, diabetes mellitus, especially with ketoacidosis, diabetic polyneuropathies;

• with malabsorption syndrome, chronic liver diseases;

• with myocardial dystrophy, peripheral vascular spasms. In a state of convalescence after illnesses with a febrile syndrome.

For oral administration, the drug is prescribed in the following doses: For diseases of the neuromuscular system (myodystrophy, amyotrophic lateral sclerosis, etc.), 50-100 mg per day (50-100 drops of 5% solution, 25-30 drops of 10% solution or 7-15 drops of 30% solution) within 1-2 months. Repeated courses in 2-3 months. For men with impaired spermatogenesis and potency, 100-300 mg per day (100-300 drops of 5% solution, 50-150 drops of 10% solution or 15-46 drops of 30% solution) in combination with hormonal therapy for a month. With threatening abortion, 100-150 mg per day (100-150 drops of 5% solution, 50-75 drops of 10% solution, or 15-23 drops of 30% solution). With habitual abortion and deterioration of intrauterine development of the fetus 100-150 mg per day (100-150 drops of 5% solution,50-75 drops of a 10% solution or 15-23 drops of a 30% solution) in the first 2-3 months of pregnancy, every day or every other day. In diseases of peripheral vessels, myocardial dystrophy, atherosclerosis, 100 mg per day (100 drops of 5% solution, 50 drops 10% solution or 15 drops of 30% solution) in combination with vitamin A. The duration of the course is 20-40 days, after 3-6 months the course of treatment can be repeated.In case of skin diseases from 15 to 100 mg per day (15-100 drops of 5% solution, 7-50 drops of 10% solution or 2-5 drops of 30% solution) within 20-40 days. 1 drop from an eye pipette contains:? - Tocopherol acetate in 5% solution - 1 mg, in 10% solution - 2 mg; in a 30% solution - 6.5 mg.50 drops of a 10% solution or 15 drops of a 30% solution) in combination with vitamin A. The duration of the course is 20-40 days, after 3-6 months the course of treatment can be repeated.In case of skin diseases from 15 to 100 mg per day (15-100 drops 5% solution, 7-50 drops of 10% solution or 2-5 drops of 30% solution) within 20-40 days. 1 drop from an eye pipette contains:? - Tocopherol acetate in 5% solution - 1 mg, in 10% solution - 2 mg; in a 30% solution - 6.5 mg.50 drops of a 10% solution or 15 drops of a 30% solution) in combination with vitamin A. The duration of the course is 20-40 days, after 3-6 months the course of treatment can be repeated.In case of skin diseases from 15 to 100 mg per day (15-100 drops 5% solution, 7-50 drops of 10% solution or 2-5 drops of 30% solution) within 20-40 days. 1 drop from an eye pipette contains:? - Tocopherol acetate in 5% solution - 1 mg, in 10% solution - 2 mg; in a 30% solution - 6.5 mg.

30% oily solution of tocopherol acetate.

Increased individual sensitivity to the drug.

With caution: hypoprothrombinemia (against the background of vitamin K deficiency - it can increase with a dose of vitamin E of more than 400 IU), severe atherosclerosis of the coronary arteries, myocardial infarction, increased risk of thromboembolism.

pharmachologic effect

Vitamin E is a natural antioxidant. Protects the cell membranes of body tissues from oxidative changes; stimulates the synthesis of heme and heme-containing enzymes - hemoglobin, myoglobin, cytochromes, catalase, peroxidase. Inhibits the oxidation of unsaturated fatty acids and selenium. Inhibits cholesterol synthesis. Prevents hemolysis of erythrocytes, increased permeability and fragility of capillaries, dysfunction of seminiferous tubules and testicles, placenta, normalizes reproductive function; prevents the development of atherosclerosis, degenerative-dystrophic changes in the heart muscle and skeletal muscles.

Indications

Hypovitaminosis E; complex therapy of conditions accompanied by an increased need of the body for vitamin E: with muscular dystrophies, dermatomycosis, amyotrophic lateral sclerosis, asthenic and neurasthenic syndromes, fatigue, paresis, myasthenia gravis, myopathies, with menstrual irregularities, threatened abortion, menopause, dysfunction of the gonads in men and women; with dermatoses, psoriasis; with atrophy of the respiratory tract mucosa, periodontal disease; with rheumatic diseases: fibrositis, tendopathies, diseases of the joints and spine; with endocrine diseases: thyrotoxicosis, diabetes mellitus, especially with ketoacidosis, diabetic polyneuropathies; with malabsorption syndrome, chronic liver diseases; with myocardial dystrophy, peripheral vascular spasms.In a state of convalescence after illnesses with a febrile syndrome.

Contraindications

Increased individual sensitivity to the drug. With caution: hypoprothrombinemia (against the background of vitamin K deficiency - it can increase with a dose of vitamin E of more than 400 IU), severe atherosclerosis of the coronary arteries, myocardial infarction, increased risk of thromboembolism.

special instructions

It should be borne in mind that in newborns with low body weight, hypovitaminosis E may occur due to the low permeability of the placenta (the fetal blood contains only 20-30% of vitamin E of its concentration in the mother's blood). A diet high in selenium and sulfur-containing amino acids reduces the need for vitamin E.

Composition

30% oily solution of tocopherol acetate.

Method of administration and dosage

For oral administration, the drug is prescribed in the following doses: For diseases of the neuromuscular system (myodystrophy, amyotrophic lateral sclerosis, etc.), 50-100 mg per day (50-100 drops of 5% solution, 25-30 drops of 10% solution or 7-15 drops of 30% solution) within 1-2 months. Repeated courses in 2-3 months. For men with impaired spermatogenesis and potency, 100-300 mg per day (100-300 drops of a 5% solution, 50-150 drops of a 10% solution or 15-46 drops of a 30% solution) in combination with hormonal therapy for a month. With a threatening abortion, 100-150 mg per day (100-150 drops of a 5% solution, 50-75 drops of a 10% solution or 15-23 drops of a 30% solution). With the usual abortion and deterioration of intrauterine development of the fetus, 100-150 mg per day (100-150 drops of a 5% solution,50-75 drops of a 10% solution or 15-23 drops of a 30% solution) in the first 2-3 months of pregnancy every day or every other day. For peripheral vascular diseases, myocardial dystrophy, atherosclerosis, 100 mg per day (100 drops of 5% solution, 50 drops of 10% solution or 15 drops of 30% solution) in combination with vitamin A. Course duration 20-40 days, after 3-6 months the course of treatment can be repeated. For skin diseases from 15 to 100 mg per day (15-100 drops of 5% solution, 7-50 drops of 10% solution or 2-5 drops of 30% solution) for 20-40 days. 1 drop from an eye dropper contains:? - Tocopherol acetate in 5% solution - 1 mg, in 10% solution - 2 mg; in a 30% solution - 6.5 mg.50 drops of a 10% solution or 15 drops of a 30% solution) in combination with vitamin A. The duration of the course is 20-40 days, after 3-6 months the course of treatment can be repeated. For skin diseases from 15 to 100 mg per day (15-100 drops of 5% solution, 7-50 drops of 10% solution or 2-5 drops of 30% solution) for 20-40 days. 1 drop from an eye dropper contains:? - Tocopherol acetate in 5% solution - 1 mg, in 10% solution - 2 mg; in a 30% solution - 6.5 mg.50 drops of a 10% solution or 15 drops of a 30% solution) in combination with vitamin A. The duration of the course is 20-40 days, after 3-6 months the course of treatment can be repeated. For skin diseases from 15 to 100 mg per day (15-100 drops of 5% solution, 7-50 drops of 10% solution or 2-5 drops of 30% solution) for 20-40 days. 1 drop from an eye dropper contains:? - Tocopherol acetate in 5% solution - 1 mg, in 10% solution - 2 mg; in a 30% solution - 6.5 mg.

Side effects

Allergic reactions. The use of large doses of the drug can cause dyspeptic disorders, decreased performance, weakness, thrombophlebitis, pulmonary embolism, thrombosis, increased creatine kinase activity, creatinuria, hypercholesterolemia, white hair growth in areas of alopecia with epidermolysis blister.

Drug interactions

Strengthens the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, antioxidants. Increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides. High-dose vitamin E supplementation can cause vitamin A deficiency in the body. Increases the effectiveness of antiepileptic drugs in patients with epilepsy (in whom the content of lipid peroxidation products in the blood is increased). The simultaneous use of vitamin E at a dose of more than 400 U / day with anticoagulants (coumarin and indandione derivatives) increases the risk of hypoprothrombinemia and bleeding. Cholestyramine, colestipol, mineral oils reduce absorption. High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

Overdose

Symptoms: when taken for a long period at doses of 400-800 U / day (1 mg = 1.21 IU) - blurred vision, dizziness, headache, nausea, unusual fatigue, diarrhea, gastralgia, asthenia, when taken more than 800 U / day for a long period - increased risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, disorders of sexual function, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, hemorrhage in the retinal membrane of the eye stroke, ascites. Treatment: symptomatic, drug withdrawal, prescription of glucocorticosteroid drugs.

Storage conditions

In a place protected from light and out of reach of children at a temperature not exceeding 25 ? —