Sinuforte lyophilisate d / pr-ra d / intranase introduction. 50mg, No. 1

• Complex therapy of acute and chronic sinusitis: sinusitis, frontal sinusitis, ethmoiditis and sphenoiditis (in the case of purulent sinusitis, occurring with symptoms of generalization of infection and / or orbital complications, SinuforteЃ should be used only in combination with antibiotics).

• With an uncomplicated course of the disease, it is possible to use the drug as a means of monotherapy under the supervision of a physician;

• complex therapy of rhinosinusitis accompanied by exudative otitis media;

• the period of early postoperative rehabilitation after endoscopic surgical interventions on the paranasal sinuses.

The drug is administered intranasally.

With each press, the dispenser sprays 0.13 ml (2-3 drops) of the drug, which is about 1.3 mg of the drug (single dose). For adults and children over 5 years of age, the drug is administered 1 time / day by a single spray into each nasal passage. It is preliminarily recommended to make 2-3 test sprays into the air. The drug is recommended to be used daily, if necessary, it can also be used every other day.

The duration of one course of treatment is 12-16 days with the introduction of the drug every other day or 6-8 days with daily use.

Mode of application

1. Unscrew the cap from the vial with the drug and remove the stopper.

2. Open the solvent bottle by breaking off the upper part.

3. Completely pour the contents of the solvent into the vial with the preparation.

4. Screw the dispenser onto the bottle and shake until the drug is completely dissolved.

5. Remove the protective cap from the dispenser spray.

6. Perform 2-3 test sprays into the air.

7. With the head upright, insert a dispenser into each nasal passage, hold your breath and spray with one press.

Lyophilisate for preparation of a solution for intranasal administration from white to light brown, hygroscopic; solvent - a clear, colorless liquid; the prepared solution is from colorless to light yellow.

1 fl.

lyophilisate of juice and extract of fresh tubers of European cyclamen 50 mg (hemolytic index 1: 6000-1: 12000)

Solvent: water d / i - 5 ml.

• Polypoid rhinosinusitis;

• paranasal sinus cysts;

• allergic rhinosinusopathies;

• allergic reactions (delayed and immediate type);

• arterial hypertension II-III stage;

• pregnancy (safety of use has not been studied);

• lactation period (safety of use has not been studied);

• children under 5 years of age (use in children under 5 years of age has not been studied);

• hypersensitivity to the components of the drug.

pharmachologic effect

A herbal preparation for the treatment of inflammatory diseases of the paranasal sinuses and nasal cavity. The drug acts on the sensitive receptors of the trigeminal nerve in the middle nasal passage and causes reflex secretion in the nasal mucosa and paranasal sinuses. Stimulated hypersecretion is accompanied by a change in the rheological properties of the secretion and the normalization of its viscosity. Reflex hypersecretion in combination with the anti-edematous action of the drug leads to the evacuation of secretions from the sinuses into the nasopharynx and provides physiological drainage of all sinuses at the same time. The drug helps to restore mucociliary transport in the nasal cavity and paranasal sinuses by increasing the presence of the liquid part of the secretion in the surface layer of mucus.SinuforteЃ enhances blood microcirculation in the nasal mucosa and paranasal sinuses. This is because parasympathetic stimulation, which activates secretion, also causes vasodilation of the vessels supplying the glands. Enhanced reflex secretion in the form of serous-mucosal secretions is detected after a few minutes and can last from 30 to 120 minutes, depending on the individual characteristics of the organism.

Pharmacokinetics

The effect of SinuforteЃ is due to the combined effects of cyclamen components, the most studied of which are triterpene saponins. Carrying out kinetic studies is not possible, since all the components together cannot be traced using markers or bioassays. For the same reason, it is impossible to detect drug metabolites.

Side effect

There may be a feeling of mild or moderate burning in the nasal cavity, salivation and / or lacrimation in response to irritation of the sensitive receptors of the trigeminal nerve. In some cases, redness of the face, a short headache in the frontal region, or a pale pink discharge from the nose as a result of capillary diapedesis may appear. The above short-term physiological reactions confirm the reflex mechanism of the drug's action and do not require discontinuation of treatment. Allergic reactions are possible (including skin rash, shortness of breath, etc.). In these cases, the patient is advised to stop taking the drug and consult a specialist.

Application during pregnancy and lactation

The use of the drug during pregnancy and lactation is contraindicated (safety of use has not been studied).

Application in children

Contraindicated in children under 5 years of age.

special instructions

During postoperative rehabilitation after endoscopic interventions, SinuforteЃ is used on the second day to cleanse (sanitize) the paranasal sinuses and nasal cavity and reduce swelling of the mucous membrane. Avoid getting SinuforteЃ in the eyes due to the irritating effect of the drug on the mucous membrane of the eye and the possible development of acute conjunctivitis. It is recommended to hold your breath during the administration of the drug. Direct spraying of the drug should be carried out with one press with the head upright. It is recommended to consult an otorhinolaryngologist before use.

Overdose

Currently, no cases of SinuforteЃ drug overdose have been reported. Symptoms: exceeding a single dose does not lead to an increase in the therapeutic effect and can cause a strong burning sensation and pain in the nasopharynx. Treatment: when symptoms of an overdose appear, it is necessary to carry out symptomatic therapy - rinse the nasal cavity, rinse the throat with warm water and apply antihistamines.

Drug interactions

It is necessary to refrain from preliminary administration, as well as the simultaneous use of local anesthetics and / or local decongestants in connection with a possible violation of the mechanism of action of SinuforteЃ. If necessary, a combination of SinuforteЃ with antibacterial drugs is possible and permissible. Interactions with other drugs have not yet been studied.