Roncoleukin 500 000 IU 1 ampoule 1 ml
DESCRIPTION
Roncoleukin (Roncoleukin) - solution for injection as an immunocorrector for all types of animals. In appearance, it is a transparent colorless or light yellow liquid.
COMPOSITION
Roncoleukin contains recombinant human interleukin-2 (IL-2), isolated from the cells of the yeast Saccharomyces cerevisiae and excipients: sodium dodecyl sulfate (SDS), D-mannitol, dithiothreitol (DTT), acid ammonium carbonate, water for injection.
1 ampoule of Roncoleukin (1 ml) contains: recombinant human interleukin-2 0.5 mg (500,000 ME); sodium dodecyl sulfate - 5 mg; D-mannitol - 25 mg; dithiothreitol - 0.08 mg; ammonium carbonate sour - 0.79 mg; water for injection up to 1 ml.
PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: cytokine. ATX code: L03AC.
Interleukin-2 is produced by a subpopulation of T-lymphocytes (T-helper cells I) in response to antigenic stimulation.
IL-2 acts on T-lymphocytes, enhancing their proliferation and subsequent synthesis of IL-2. The mechanism of action of IL-2 is due to its binding to specific receptors present on various cellular targets.
IL-2 has a directed effect on the growth, differentiation and activation of T- and B-lymphocytes, monocytes, macrophages, oligodendroglial cells, Langerhans epidermal cells. The development of cytolytic activity of natural killer cells and cytotoxic T-lymphocytes depends on its presence. IL-2 induces the formation of lymphokine-activated killers and activates tumor-infiltrating cells.
Expansion of the spectrum of the lyzing action of effector cells leads to the elimination of various pathogenic microorganisms, infected and malignant cells, which provides immune protection against the growth of tumor cells, viral, bacterial and fungal infections.
DOSAGE AND APPLICATION
Dogs, cats, ferrets and fur animals
Treatment: viral, bacterial and fungal diseases - 2-5 injections intravenously (intravenously) or subcutaneously (subcutaneously) at the rate of 10,000-15,000 IU / kg with an interval of 24-72 hours; oncological diseases - 5 intravenous or subcutaneous injections at the rate of 15,000-20,000 IU / kg, repeated courses are carried out in a month.
Prevention: to enhance the effectiveness of vaccines and reduce post-vaccination complications - one sc injection of 5000 IU / kg simultaneously or 24-48 hours before vaccination; prevention of viral, bacterial and fungal diseases - 1-2 injections s / c, i / v or orally at the rate of 5000 IU / kg with an interval of 48 hours; prevention of complications during surgery - before and / or after surgery - 1-2 s / c or i / v injections with an interval of 48 hours; relieving stress during various manipulations, transportation, etc. - for two days, once at the rate of 5000 IU / kg; normalization of immunity of old and weakened animals - 2 sc injections at the rate of 10,000 IU / kg with an interval of 48 hours once every 3-6 months.
Horses
Apply: for respiratory diseases: pulmonary emphysema, bronchitis, pneumonia, - s / c, i / v, orally 2-3 times at a dose of 1000 IU / kg with an interval of 24-72 hours; to prevent recurrence of chronic pathologies of the respiratory system - once a month, once a SC, IV, orally at a dose of 2000 IU / kg with an interval of 48-72 hours; for skin diseases (photoexanthema, erythema multiforme) - 2 injections IV, at a dose of 1000 IU / kg with an interval of 48 hours in combination with local anti-inflammatory therapy, with dermatitis - IV drip or s / c 3-5 injections with an interval 48 hours at the same dosage; in case of violation of mineral metabolism - twice 1000 IU / kg IV, n / a with an interval of 48-72 hours, repeated courses are carried out after a month and after 2 months; for traumatic injuries, pododermatitis, burns and frostbite - 2-3 injections (the first - intravenous drip, subsequent - s / c) at a dose of 1000-2000 IU / kg with an interval of 48 hours; for oncological diseases (melanosarcoma) - 3-5 injections at the rate of 1000-2000 IU / kg with an interval of 48-72 hours, the first injection is intravenous drip, the second is subcutaneous, then - 1-2 injections per month s / c; to correct the immunity of foals - 2 injections at the rate of 1000-2000 IU / kg i.v., s.c. or orally; the first introduction - on the 3-4th day, and the second - on the 10-14th day after birth; to prevent the spread of viral infections - 2-3 intravenous, s / c injections at the rate of 1000 IU / kg for the entire livestock in contact with sick animals; for the prevention of transport stress - once s / c, i / v, orally at the rate of 1000 IU / kg 24-72 hours before loading the horse; old and weakened animals - s / c, i / v, orally at a dose of 1000 IU / kg of body weight, 2-3 injections monthly.
During the period of high physical exertion, it is administered to increase the reserve capabilities of the body - once a week s / c, i / v, orally at a dose of 1000 IU / kg.
Immunorehabilitation after the use of corticosteroids and a course of other immunosuppressants - s.c., i.v., orally 1000 IU / kg 2-3 times with an interval of 48-72 hours.
Cattle (cattle)
Apply: to stimulate immunity in newborn calves - once s / c 100,000 IU per calf; for the prevention and treatment of viral, bacterial diseases - 1-3 subcutaneous injections at the rate of 2000-3000 IU / kg with an interval of 48 hours; to enhance the effectiveness of vaccination - once at the same time as s / c vaccination at the rate of 1000-2000 IU / kg; with necrobacteriosis - 2-3 injections s / c or iv (slowly) at a dose of 1000 IU / kg with an interval of 7-10 days; for chlamydia - three times s / c with an interval of 7 days at the rate of 1000 IU / kg; to normalize (restore) sexual cyclicity in cows with ovarian hypofunction, manifested by prolonged anaphrodesia - twice 500,000 IU per animal with an interval of 36 hours.
Small cattle
The same indications and doses as for cattle.
Pigs
Apply: to stimulate immunity in newborn piglets - once s / c, orally at a dose of 3000-5000 IU / kg; for the prevention of viral, bacterial and fungal diseases - 1-2 s.c. injections at the rate of 2000 IU / kg with an interval of 48 hours; to enhance the effectiveness of vaccination - once at the same time as vaccination of young p / c at the rate of 2000-3000 IU / kg.
Farm bird
It is used to stimulate the immunity of young animals and to enhance the effectiveness of vaccination and reduce post-vaccination complications - once s / c, orally at the rate of 2000 - 3000 IU / kg.
SPECIAL INSTRUCTIONS
It is not recommended to administer to horses shortly before or immediately after exercise, or in hot weather.
Horses with severe lesions of the conducting system and the heart valve apparatus are used with caution, fractionally.
The peculiarities of the drug reaction during the initial or course use of the drug have not been established.
Joint administration in one syringe or dropper with glucose is not recommended.
Slaughter products, milk, poultry eggs after the application of Roncoleukin are sold without restriction, without a waiting period.
SIDE EFFECTS
In some cases, during the use of Roncoleukin, a short-term increase in body temperature is possible, which is stopped by drugs. With subcutaneous administration of the drug, local reactions to the injection of the drug are possible - soreness, induration, redness at the injection site. Soreness usually resolves immediately after injection, and redness and induration within 24 to 48 hours.
SHELF LIFE AND STORAGE
Shelf life - 2 years from the date of issue, subject to the storage and transportation conditions. After the expiration date it is not suitable for use.
Roncoleukin is stored and transported in the manufacturer's packaging in a dry, clean, dark place at a temperature of 2 В° C to 10 В° C. Transportation is allowed at a temperature of 25 В° C for 10 days. Should be stored out of the reach of children.
PACKAGING
Roncoleukin is sterilely packaged in 1 ml each in vacuum-sealed glass ampoules with a break ring, hermetically sealed with rubber stoppers and reinforced with aluminum caps. Ampoules and vials are packed in blisters, and blisters in boxes. Each box is supplied with instructions for use.
Specifications
Bonus points
0
KolVUP
3
Manufacturer
Biotech
Temperature regime
from +2 to +10
Teaser
as an immunocorrector for all types of animals