Rinikold HotMix powder d / prig. oral solution, Lemon 5g, No. 10

Symptomatic treatment of colds, flu, ARVI (febrile and pain syndrome, rhinorrhea).

Pour the contents of 1 sachet (sachet) into a glass, pour hot water, stir until completely dissolved and drink (sugar or honey can be added if desired). It is necessary to take the drug with a large amount of liquid, 1-2 hours after eating.

Adults and children over 15 years old: take one sachet 3-4 times / day with intervals between doses of 4-6 hours. The maximum daily dose is 4 sachets.

The drug is not recommended to be used for more than 5 days as a pain reliever and for more than 3 days as an antipyretic without prescribing and supervising a doctor.

An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician. Do not exceed the indicated dose. In case of overdose, see your doctor immediately, even if you feel well.

Powder for oral solution

• paracetamol 750 mg

• caffeine 30 mg

• phenylephrine hydrochloride 10 mg

• pheniramine maleate 20 mg

Excipients: sodium chloride, citric acid anhydrous, sodium citrate anhydrous, aspartame, lactose anhydrous, mannitol, disodium edetate, flavor, dye.

• Taking other medicines containing substances that make up the drug;

• concomitant use of tricyclic antidepressants, beta-blockers, MAO inhibitors, incl. up to 14 days after cancellation;

• pregnancy, lactation period;

• children's age (up to 15 years).

• hypersensitivity to paracetamol and other components that make up the drug.

With caution - severe atherosclerosis of the coronary arteries, arterial hypertension, thyrotoxicosis, pheochromocytoma, diabetes mellitus and hereditary disorders of sugar absorption, bronchial asthma, chronic obstructive pulmonary disease, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia and Rhino-Giothora syndrome , hepatic and / or renal failure, angle-closure glaucoma, prostatic hyperplasia.

pharmachologic effect

Combined drug. Paracetamol has an antipyretic and analgesic effect: it reduces the pain syndrome observed in colds - sore throat, headache, muscle and joint pain, and reduces fever.

Phenylephrine has a vasoconstrictor effect - it reduces edema and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses.

Pheniramine has an anti-allergic effect: eliminates itching of the eyes, nose and throat, swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses, reduces exudative manifestations.

Caffeine has a stimulating effect on the central nervous system, which leads to a decrease in fatigue and drowsiness, and to an increase in mental and physical performance.

Side effect

Allergic reactions: skin rash, itching, urticaria, angioedema.

From the nervous system: dizziness, sleep disturbance, irritability.

From the side of the cardiovascular system: increased blood pressure, tachycardia.

From the digestive system: nausea, vomiting, pain in the epigastric region, dry mouth, hepatotoxic effect.

From the senses: mydriasis, accommodation paresis, increased intraocular pressure.

From the side of hematopoiesis: thrombocytopenia, agranulocytosis.

Others: bronchospasm, urinary retention.

Application for violations of liver function

Precaution - liver failure.

Application for impaired renal function

Precaution - renal failure.

Application in children

Contraindication: children's age (up to 15 years).

special instructions

Before taking the drug, a doctor's consultation is necessary in case of taking metoclopramide, domperidone, cholestyramine, anticoagulants (warfarin).

During the period of treatment, one should refrain from taking alcohol, sleeping pills and anxiolytic (tranquilizers) drugs.

Do not take with other medicines containing paracetamol.

If symptoms persist within 3-5 days, seek medical attention.

In order to avoid toxic damage to the liver, paracetamol should not be combined with the intake of alcoholic beverages, as well as taken by persons prone to chronic alcohol consumption.

Influence on the ability to drive vehicles and use mechanisms

Care should be taken when performing work that requires concentration of attention, increased speed of motor and mental reactions.

Overdose

It is caused, as a rule, by paracetamol and manifests itself after taking more than 10-15 g of paracetamol.

Symptoms: pallor of the skin, anorexia, nausea, vomiting; increased activity of hepatic transaminases, increased prothrombin time. In case of symptoms of an overdose, an urgent need to consult a doctor.

Treatment: gastric lavage followed by the appointment of activated carbon; symptomatic therapy, the introduction of methionine 8-9 hours after the overdose and N-acetylcysteine ??- 12 hours later.

Drug interactions

Enhances the effects of MAO inhibitors, sedatives, ethanol.

Antidepressants, antiparkinsonian drugs, antipsychotics, phenothiazine derivatives - increase the risk of urinary retention, dry mouth, constipation.

Glucocorticosteroids increase the risk of developing glaucoma.

Paracetamol reduces the effectiveness of uricosuric drugs.

Chlorpheniramine concurrently with MAO inhibitors, furazolidone can lead to hypertensive crisis, agitation, hyperpyrexia.

Concomitant administration of halothane increases the risk of ventricular arrhythmias.

Phenylephrine reduces the hypotensive effect of guanethidine.

Guanethidine enhances the alpha-adrenostimulating effect, and tricyclic antadepressants enhance the sympathomimetic effect of phenylephrine.

With the simultaneous administration of the drug with barbiturates, diphenin, carbamazepine, rifampicin and other inducers of microsomal liver enzymes, the risk of developing the hepatotoxic effect of paracetamol increases.