Retinol palmitate oil solution, 10 ml

Hypovitaminosis, vitamin deficiency A. In complex therapy:

• infectious and inflammatory diseases (measles, dysentery, influenza, tracheitis, bronchitis, etc.),

• lesions and diseases of the skin (cracks, ichthyosiform erythroderma, acne, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema, skin tuberculosis),

• eye diseases (retinitis pigmentosa, hemeralopia, xerophthalmia, keratomalacia, eczematous eyelid lesions),

• gastrointestinal diseases (erosive gastroduodenitis, gastric ulcer and duodenal ulcer),

• cirrhosis of the liver.

Prescribed for the prevention of calculus formation in the biliary and urinary tract.

The use of the drug must be carried out under the supervision of a physician. The drug is taken orally after meals in the early morning or late evening.
Therapeutic doses for adults with mild and moderate vitamin deficiencies are up to 33,000 IU / day, for children - 1000 - 5000 IU / day, depending on age.
For eye diseases, adults are prescribed - 50,000-100,000 IU per day and at the same time 0.02 g of riboflavin.
In dermatology, in the treatment of acne and ichthyosiform erythroderma in adults at 100,000-300,000 IU / day, children at 5,000-10000 IU / kg per day. For skin diseases, adults are prescribed 50,000-100,000 IU of retinol palmitate per day.
In gastroenterology- 50,000 IU per day. Single doses of retinol palmitate should not exceed 50,000 IU for adults and 5,000 IU for children. The daily dose for adults is 100,000 IU and 20,000 IU for children. For the treatment of acne and ichthyosiform erythroderma in adults, 100,000-300,000 IU.

active substance : retinol palmitate (vitamin A) (in terms of 100%) - 55.1 g.
auxiliary substances : butylhydroxytoluene, butylhydroxyanisole, rapeseed oil up to 1 liter.
1 ml of solution contains 100,000 IU (1 drop of solution from a dropper or eye dropper contains 3300 IU). 1 mg of retinol palmitate corresponds to 1817 IU.

Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases.

Use with caution in nephritis, heart failure II-III century, alcoholism, viral hepatitis, renal failure, old age, childhood.

The trade name is Retinol palmitate.

International Non-Proprietary Name (INN) or Generic Name : Retinol

Dosage form : for oral administration in oil.

Composition:
active substance : retinol palmitate (vitamin A) (in terms of 100%) - 55.1 g.
Auxiliary substances : butylhydroxytoluene, butylhydroxyanisole, rapeseed oil up to 1 liter.
1 ml of solution contains 100,000 IU (1 drop of solution from a dropper or eye dropper contains 3300 IU). 1 mg of retinol palmitate corresponds to 1817 IU.

Description
Light yellow to yellow clear oily liquid without rancid odor.

Pharmacotherapeutic group : Vitamin.

pharmachologic effect
Vitamin A has a general strengthening effect, normalizes tissue metabolism, participates in redox processes (due to a large number of unsaturated bonds), in the synthesis of mucopolysaccharides, proteins, lipids, in mineral metabolism, and in the formation of cholesterol. Enhances the production of lipase and trypsin, enhances myelopoiesis, cell division processes. Has a positive effect on the function of the lacrimal, sebaceous and sweat glands; increases resistance to diseases of the mucous membranes, respiratory tract and intestines; increases the body's resistance to infection. It enhances the division of skin epithelial cells, rejuvenates the cell population, inhibits keratinization processes, enhances the synthesis of glycosaminoglycans, activates the interaction of immunocompetent cells with each other and the cells of the epidermis.
Stimulates cell regeneration. Participates in the processes of photoreception (contributes to the adaptation of a person to the dark). Local action is due to the presence of specific retinol-binding receptors on the surface of epithelial cells.

Indications for use
Hypovitaminosis, vitamin deficiency A. In complex therapy:

• infectious and inflammatory diseases (measles, dysentery, influenza, tracheitis, bronchitis, etc.),

• lesions and diseases of the skin (cracks, ichthyosiform erythroderma, acne, hyperkeratosis, seborrheic dermatitis, psoriasis, neurodermatitis, some forms of eczema, skin tuberculosis),

• eye diseases (retinitis pigmentosa, hemeralopia, xerophthalmia, keratomalacia, eczematous eyelid lesions),

• gastrointestinal diseases (erosive gastroduodenitis, gastric ulcer and duodenal ulcer),

• cirrhosis of the liver.

Prescribed for the prevention of calculus formation in the biliary and urinary tract.

Contraindications
Hypersensitivity to the components of the drug, hypervitaminosis A, pregnancy, cholelithiasis, chronic pancreatitis, acute inflammatory skin diseases.

Use with caution in nephritis, heart failure II-III century, alcoholism, viral hepatitis, renal failure, old age, childhood.

Pregnancy and lactation
It is not recommended to take the drug during pregnancy and breastfeeding.

Method of administration and dosage
The use of the drug must be carried out under the supervision of a physician. The drug is taken orally after meals in the early morning or late evening.
Therapeutic doses for adults with mild and moderate vitamin deficiencies are up to 33,000 IU / day, for children - 1000 - 5000 IU / day, depending on age.
For eye diseases, adults are prescribed - 50,000-100,000 IU per day and at the same time 0.02 g of riboflavin.
In dermatology, in the treatment of acne and ichthyosiform erythroderma in adults at 100,000-300,000 IU / day, children at 5,000-10000 IU / kg per day. For skin diseases, adults are prescribed 50,000-100,000 IU of retinol palmitate per day.
In gastroenterology- 50,000 IU per day. Single doses of retinol palmitate should not exceed 50,000 IU for adults and 5,000 IU for children. The daily dose for adults is 100,000 IU and 20,000 IU for children. For the treatment of acne and ichthyosiform erythroderma in adults, 100,000-300,000 IU.

Side effects
In some patients, with prolonged use, dry skin and mucous membranes, increased sensitivity of the facial skin, and seizures are observed. These phenomena go away on their own when the dose is reduced or the drug is temporarily withdrawn.
When treating acne, after 7-10 days of admission, an exacerbation of the local inflammatory reaction is observed, which does not require additional treatment and subsequently stops. In some cases, drug intolerance is noted, which requires its withdrawal.

Overdose
Long-term daily intake of vitamin A (100,000 IU - children, 200,000 IU - adult) can cause intoxication, hypervitaminosis A. Symptoms of hypervitaminosis A in adults - headache, drowsiness, weakness, facial flushing, nausea, vomiting, pain in the bones of the lower extremities, violation of gait. In children can be observed: fever, drowsiness, sweating, vomiting, skin rashes. If symptoms of an overdose appear, the drug should be canceled. Excess retinol palmitate is excreted from the body by ingestion of alcohol. With pronounced symptoms of intoxication, glucocorticosteroids should be administered orally.

Interaction with other medicinal products
During long-term therapy with tetracyclines, it is not recommended to prescribe vitamin A (the risk of intracranial hypertension increases).
Salicylates and glucocorticosteroids reduce the risk of side effects.
Cholestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamin A (dose increases may be required).
Oral contraceptives increase the plasma concentration of vitamin A.
Isotretinoin increases the risk of toxic effects.
Vitamin E reduces toxicity, absorption, liver deposition and vitamin A utilization; high doses of vitamin E can reduce vitamin A stores in the body.
Weakens the effect of calcium preparations, increases the risk of developing hypercalcemia.

Special instructions
Do not take simultaneously multivitamin complexes containing vitamin A in order to avoid overdose.

Storage conditions List B. In the dark place at a temperature not exceeding 10 ? C. Keep out of the reach of children.

Shelf life is
2 years. Do not use after the expiration date.

Terms of dispensing from pharmacies
Dispense without a prescription