Retinol acetate (Vitamin A) capsules 33000ME, No. 30

• Ichthyosis

• hyperkeratosis,

• seborrheic dermatitis,

• psoriasis,

• pyoderma,

• atopic dermatitis,

• neurodermatitis,

• eczema,

• frostbite,

• burns,

• erosion,

• ulcers

• cracks,

• skin atrophy after prolonged use of GCS.

Retinol acetate is taken orally. Therapeutic doses for mild and moderate avitaminosis: for adults - up to 33,000 IU per day, for hemeralopia, xerophthalmia, retinitis pigmentosa - 50,000-100,000 IU per day. Children - 1000-5000 IU per day, depending on age. For skin diseases: adults - 50,000-100,000 IU per day, children - 5,000-10000-20,000 IU per day.

1 capsule contains retinol acetate 33 thousand IU

• Hypervitaminosis A,

• I trimester of pregnancy,

• acute inflammatory skin diseases,

• hypersensitivity to the components of the drug.

pharmachologic effect

Dermatoprotective agent. Retinol acetate stimulates skin regeneration, enhances the division of skin epithelial cells, inhibits keratinization processes, and prevents the development of hyperkeratosis. Local action is due to the presence of specific retinol-binding receptors on the surface of epithelial cells.

Indications

• Ichthyosis

• hyperkeratosis,

• seborrheic dermatitis,

• psoriasis,

• pyoderma,

• atopic dermatitis,

• neurodermatitis,

• eczema,

• frostbite,

• burns,

• erosion,

• ulcers

• cracks,

• skin atrophy after prolonged use of GCS.

Contraindications

• Hypervitaminosis A,

• I trimester of pregnancy,

• acute inflammatory skin diseases,

• hypersensitivity to the components of the drug.

Application during pregnancy and lactation

Retinol acetate is contraindicated for use in the first trimester of pregnancy. During lactation (breastfeeding) it is not recommended to apply to the skin of the mammary glands.

Special instructions The teratogenic effect of increased doses of retinol persists even after the termination of its intake, therefore, it is recommended to plan pregnancy when using the drug only after 6-12 months.

Composition

1 capsule contains retinol acetate 33 thousand IU

Method of administration and dosage

Retinol acetate is taken orally. Therapeutic doses for mild and moderate avitaminosis: for adults - up to 33,000 IU per day, for hemeralopia, xerophthalmia, retinitis pigmentosa - 50,000-100,000 IU per day. Children - 1000-5000 IU per day, depending on age. For skin diseases: adults - 50,000-100,000 IU per day, children - 5,000-10000-20,000 IU per day.

Side effects

Local reactions: increased itching, hyperemia. Possibly: allergic reactions. The occurrence of these side effects requires the abolition of Retinol acetate.

Drug interactions

Estrogens and oral contraceptives containing them enhance the absorption of retinol, which can lead to the development of A-hypervitaminosis. During long-term therapy with tetracyclines, it is not recommended to prescribe vitamin A (the risk of developing intracranial hypertension increases). Retinol should be taken 1 hour before or 4-6 hours after taking colestyramine. Retinol absorption is disturbed by nitrites.

Overdose

In acute hypervitaminosis, severe headache, dizziness are observed; drowsiness, confusion, visual disturbances, convulsions, indomitable vomiting, profuse diarrhea, severe dehydration; on the second day, a widespread rash appears, followed by large lamellar peeling, starting from the face; palpation of long tubular bones is sharply painful due to subperiosteal hemorrhages, changes in bone, soft tissues. In children, acute hypervitaminosis is characterized by anxiety, excitement, insomnia during the first day, sometimes there is drowsiness, fever up to 39 ? C, vomiting, protrusion of the large fontanelle, signs of suffocation.

Treatment: symptomatic; as an antagonist, thyroxine is prescribed, as well as ascorbic acid.

Storage conditions

In a dry, dark place at a temperature not exceeding 25 ? C.

Shelf life is 2 years.