Resflor 100ml
DESCRIPTION
Resflor (Resflor) is a drug in the form of a solution for injection, intended for the treatment of diseases of bacterial etiology and relief of inflammatory processes in cattle.
Resflor in appearance is a clear oily liquid of light yellow color.
COMPOSITION
Resflor as active ingredient in 1 cm? contains 27.4 mg of flunixin meglumine (which corresponds to 16.5 mg of flunixin) and 300 mg of florfenicol, and as auxiliary substances - N-methyl-2-pyrrolidone, propylene glycol, citric acid anhydride and polyethylene glycol.
SPECIAL INSTRUCTIONS
Vials without labels, with an expired expiration date, with a violation of the integrity of the closure, subjected to freezing, with a changed color and / or consistency of the contents, containing impurities, and also not used within 28 days after opening, are prohibited to use.
STORAGE
Store the medicinal product in the manufacturer's closed packaging, in a dry place protected from direct sunlight, separately from food and feed, at a temperature from 2 В° C to 25 В° C. The shelf life of the medicinal product, subject to storage conditions, is 2 years from the date of manufacture. After the first opening of the bottle, the drug is stored for 28 days.
PHARMACOLOGICAL PROPERTIES
Flunixin, which is part of the drug, is a non-steroidal anti-inflammatory drug with a pronounced analgesic and antipyretic effect; is a non-selective inhibitor of cyclooxygenases (COX1 and COX2), which reduces the production of prostaglandins E2. A decrease in the production of inflammatory mediators determines the analgesic, antipyretic and anti-inflammatory effect of flunixin.
Florfenicol, which is part of the drug, is a thiamphenicol derivative, in the molecule of which the hydroxyl group is replaced by a fluorine atom. The mechanism of action of the antibiotic consists in binding to the 50S ribosomal subunit in the protoplasm of a bacterial cell and blocking the enzyme peptidyl transferase, which leads to inhibition of protein synthesis in bacteria at the ribosome level.
Florfenicol is active against bacteria that produce acetyl transferase and are resistant to chloramphenicol.
Florfenicol has a wide spectrum of antibacterial action against aerobic and anaerobic, gram-positive and gram-negative bacteria, including Pasteurella multocida, Pasteurella (Mannheimia) haemolytica, Histophilus somni, Fusobacterium necrophorum, Bacteroidesraxanogenic melinella.
When administered parenterally, flunixin is rapidly absorbed and penetrates into all organs and tissues. The maximum concentration in the blood is reached after 1.3 hours, and the therapeutic concentration in the organs and tissues of animals is maintained for 48 hours. Flunixin is 99% bound to proteins and excreted from the body mainly with feces (57%) and, to a lesser extent, with urine (34%).
When administered parenterally, florfenicol is also rapidly absorbed, penetrating into all organs and tissues. The maximum concentration of the antibiotic in the blood is reached after 3.3 hours, and the therapeutic concentration in the organs and tissues of animals is maintained for 48 hours.
According to the degree of impact on the body, Resflor refers to moderately hazardous substances (hazard class 3 according to GOST 12.1.007).
INDICATIONS
Resflor is used for the treatment of respiratory diseases in cattle, such as rhinotracheitis, bronchitis, bronchopneumonia, pleurisy caused by Pasteurella (Mannheimia) haemolytica, Pasteurella multocida, Histophilus somni, as well as other infectious diseases of bacterial etiology caused by microorganisms, sensitive secondary bacterial infections manifested against the background of viral respiratory pathology.
APPLICATION
Resflor is injected subcutaneously into the neck area once, at a dose of 40 mg florfenicol and 2.2 mg flunixin per 1 kg of animal weight (which corresponds to 2 ml of Resflor per 15 kg of animal weight). If necessary and in case of a chronic course of the disease, the repeated administration of Resflora is allowed after 48 hours.
The use of underestimated dosages is not allowed due to a decrease in therapeutic efficacy.
Due to a possible painful reaction, more than 10 ml of the drug should not be injected into one place in cattle, as well as mixed with other drugs in the same syringe.
CONTRAINDICATIONS
Resflor must not be used in animals with hypersensitivity to the components of the medicinal product, with pathologies of the heart, liver, kidneys, in cases of hypovolemia, with the risk of gastrointestinal bleeding.
The medicinal product should not be used for pregnant and lactating cows, calves under 6 weeks of age, as well as sire bulls.
It is prohibited to use Resflora simultaneously with other non-steroidal anti-inflammatory drugs and corticosteroid drugs due to the increased risk of ulceration in the gastrointestinal tract of animals.
SIDE EFFECTS
Slaughter of cattle for meat is allowed no earlier than 64 days after the last administration of Resflor. The meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding fur-bearing animals.
PRECAUTIONS
When working with Resflor, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines.
It is forbidden to use empty vials of the medicinal product for household purposes.
PACKING
Resflor is packaged in 100 cm? in glass bottles of appropriate capacity, hermetically sealed with rubber stoppers, reinforced with aluminum caps with clips for first opening control.
Specifications
KolVUP
40
Manufacturer
Intervet
Temperature regime
from +2 to +25
Teaser
antibacterial drug based on florfenicol, and flunixin (non-steroidal anti-inflammatory drug) for the treatment of diseases of bacterial etiology and relief of inflammatory processes in cattle