Reamberin solution for infusion 1.5%, 500ml No. 5
Expiration Date: 05/2027
Russian Pharmacy name:
Реамберин раствор для инфузий 1.5%, 500мл №5
Adults: injected intravenously at a rate of 1-4.5 ml / min (up to 90 drops / min). The average daily dose is 10 ml / kg. The course of therapy is up to 11 days.
Children from 1 year old: injected intravenously at the rate of 6-10 ml / kg / day at a rate of 3-4 ml / min. The course of therapy is 11 days.
Studies in elderly patients have not been conducted. In this regard, the use of the drug should be started at a slower rate of administration: 20-40 drops / min (1-2 ml / min).
Studies in patients with renal impairment have not been conducted.
In this regard, it is recommended to be careful when using the drug in such patients.
If decompensated alkalosis is detected, the use of the drug should be discontinued until the acid-base state of the blood is normalized.
The solution for infusion is transparent, colorless.
1 l
meglumine sodium succinate 15 g
Excipients: sodium chloride - 6 g, potassium chloride - 0.3 g, magnesium chloride hexahydrate (in terms of anhydrous) - 0.12 g, sodium hydroxide - 1.788 g, succinic acid - up to pH 6.0 to 7.0, water d / i - up to 1 l.
Condition after traumatic brain injury, accompanied by cerebral edema;
acute renal failure;
chronic kidney disease (stage 5, GFR less than 15 ml / min);
pregnancy;
breastfeeding period;
individual intolerance.
The drug should be used with caution in alkalosis, renal failure.
pharmachologic effect
It has antihypoxic and antioxidant effects, having a positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring the energy potential of cells. The drug activates the enzymatic processes of the Krebs cycle and promotes the utilization of fatty acids and glucose by cells, normalizes the acid-base balance and blood gas composition. It has a moderate diuretic effect.
Pharmacokinetics
When administered intravenously, the drug is quickly utilized and does not accumulate in the body.
Side effect
From the side of the immune system: very rarely - allergic reactions, angioedema, anaphylactic shock. Skin and subcutaneous tissue disorders: very rarely - allergic rash, urticaria, itching. From the respiratory system: very rarely - shortness of breath, dry cough. From the side of the cardiovascular system: very rarely - tachycardia, palpitations, shortness of breath, pain in the region of the heart, chest pain, arterial hypotension / hypertension, short-term reactions in the form of a burning sensation and redness of the upper body. From the digestive system: very rarely - nausea, vomiting, metallic taste in the mouth, abdominal pain, diarrhea. From the nervous system: very rarely - dizziness, headache, convulsions, tremors, paresthesias, agitation, anxiety. General disorders and disorders at the injection site: very rarely - hyperthermia, chills,sweating, weakness, soreness at the injection site, edema, hyperemia, phlebitis. To avoid the occurrence of undesirable effects, it is recommended to observe the dosage regimen and the rate of administration of the drug. In the event of adverse reactions, it is recommended to reduce the rate of administration of the drug. If any of the undesirable effects indicated in the instructions are aggravated or any other undesirable effects not indicated in the instructions are noted, the patient should inform the doctor about it.If any of the undesirable effects indicated in the instructions are aggravated or any other undesirable effects not indicated in the instructions are noted, the patient should inform the doctor about this.If any of the undesirable effects indicated in the instructions are aggravated or any other undesirable effects not indicated in the instructions are noted, the patient should inform the doctor about it.
Application during pregnancy and lactation
The drug is contraindicated for use during pregnancy and during breastfeeding due to the lack of clinical studies in these groups of patients.
Application for impaired renal function
Contraindicated in acute renal failure, chronic kidney disease (stage 5, GFR less than 15 ml / min). It is recommended to be careful when using the drug in patients with renal impairment. Use in children The drug is prescribed for children over the age of 1 year.
Use in elderly patients
In elderly patients, the use of the drug should be started at a slower rate of administration.
special instructions
Due to the activation of aerobic processes in the body by the drug, a decrease in the concentration of glucose in the blood, the appearance of an alkaline urine reaction is possible. Patients with diabetes mellitus or patients with impaired glucose tolerance require periodic monitoring of the concentration of glucose in the blood. If the color of the solution changes or there is a sediment, the use of the drug is unacceptable. Influence on the ability to drive vehicles and use mechanisms It is not recommended to drive vehicles and work with mechanisms during the course of treatment with ReamberinЃ.
Drug interactions
The drug goes well with antibiotics, water-soluble vitamins, glucose solution. It is not recommended to mix the medicine in a bottle or container with other medicines. It is unacceptable for intravenous administration of the drug ReamberinЃ simultaneously with calcium preparations due to the possible precipitation of calcium succinate.