Ratch tablets 50mg, no. 40

Relief of symptoms of functional non-ulcer dyspepsia (chronic gastritis), including:

- bloating;

- a feeling of quick satiety;

- pain or discomfort in the upper abdomen;

- anorexia;

- heartburn;

- nausea;

- vomiting.

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Is taken orally 50 mg 3 times / day. The recommended daily dose is 150 mg. The indicated dose may be reduced according to the patient's age.

Active ingredient: itoprid hydrochloride - 50 mg

Excipients : lactose monohydrate - 65.56 mg, pregelatinized starch - 1.2 mg, croscarmellose sodium - 1.2 mg, colloidal anhydrous silicon dioxide - 0.84 mg, magnesium stearate - 1.2 mg.

Gastrointestinal bleeding, mechanical obstruction or perforation of the gastrointestinal tract;

pregnancy;

lactation period (breastfeeding);

children under the age of 16;

hypersensitivity to itopride.

Description:

Film-coated tablets of white or almost white color, round, biconvex, with a score on one side.

Composition:

Active ingredient: itoprid hydrochloride - 50 mg

Excipients : lactose monohydrate - 65.56 mg, pregelatinized starch - 1.2 mg, croscarmellose sodium - 1.2 mg, colloidal anhydrous silicon dioxide - 0.84 mg, magnesium stearate - 1.2 mg.

Clinical and pharmacological group: A drug that increases the tone and motility of the gastrointestinal tract. Acetylcholine release stimulant

Pharmaco-therapeutic group: Gastrointestinal motility stimulant, acetylcholine release stimulant

pharmachologic effect

An agent that stimulates gastrointestinal motility. Itopride enhances the propulsive motility of the gastrointestinal tract due to antagonism against dopamine D2 receptors and dose-dependent inhibition of acetylcholinesterase activity. Itopride activates the release of acetylcholine and inhibits its destruction.

Itoprid has a specific effect on the upper gastrointestinal tract, accelerates gastric transit and improves gastric emptying.

It also has an antiemetic effect due to interaction with D2 receptors located in the trigger zone. Itopride caused dose-dependent suppression of apomorphine-induced vomiting.

Does not affect serum gastrin levels.

Indications

Relief of symptoms of functional non-ulcer dyspepsia (chronic gastritis), including:

- bloating;

- a feeling of quick satiety;

- pain or discomfort in the upper abdomen;

- anorexia;

- heartburn;

- nausea;

- vomiting.

Dosage regimen

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

Is taken orally 50 mg 3 times / day. The recommended daily dose is 150 mg. The indicated dose can be reduced according to the patient's age.

Side effect

From the hematopoietic system: leukopenia, thrombocytopenia.

From the endocrine system: increased prolactin levels, gynecomastia.

From the side of the central nervous system: dizziness, headache, tremor.

From the digestive system: diarrhea, constipation, abdominal pain, increased salivation, nausea, jaundice.

Allergic reactions: flushing of the skin, pruritus, rash, anaphylaxis.

Changes in laboratory parameters: increased activity of AST and ALT, GGT, alkaline phosphatase and bilirubin level.

Contraindications for use

Gastrointestinal bleeding, mechanical obstruction or perforation of the gastrointestinal tract; pregnancy; lactation period (breastfeeding); children under the age of 16; hypersensitivity to itopride.

Application during pregnancy and lactation

Use during pregnancy and lactation (breastfeeding) is contraindicated.

special instructions

Itopride should be used with caution in patients for whom the appearance of cholinergic side reactions (associated with an increase in the action of acetylcholine under the influence of itopride) may aggravate the course of the underlying disease.

Drug interactions

Itopride enhances gastric motility, so it can affect the absorption of other drugs used simultaneously inside.

Use with extreme caution simultaneously with drugs with a low therapeutic index, as well as in dosage forms with a slow release of the active substance or drugs with an enteric coating.

Anticholinergics can weaken the effect of itopride.

Terms and conditions of storage:

Store in original packaging at temperatures up to 25 ? C.

Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies:

Dispensed by prescription.