Rakstan-Sanovel tablets 100mg, No. 30

• Rheumatoid arthritis, deforming osteoarthritis, ankylosing spondylitis, acute bursitis and tendovaginitis, soft tissue injuries;

• pain syndrome (weak and moderate intensity): arthralgia, myalgia, neuralgia, migraine, toothache and headache, algomenorrhea, pain in trauma, burns;

• febrile syndrome with colds and infectious diseases.

Inside, 50-100 mg 2-3 times / day.

Film-coated tablets

1 tab.

flurbiprofen 100 mg

• Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase,

• 'aspirin triad' (bronchial asthma, vasomotor rhinitis, acetylsalicylic acid intolerance),

• pregnancy,

• lactation period,

• hypersensitivity to NSAIDs,

• heart failure,

• swelling

• arterial hypertension,

• hemophilia,

• hypocoagulation,

• liver failure,

• Chronic renal failure,

• hearing loss

• pathology of the vestibular apparatus,

• deficiency of glucose-6-phosphate dehydrogenase,

• oppression of bone marrow hematopoiesis,

• early childhood.

pharmachologic effect

NSAIDs. It has a pronounced analgesic, anti-inflammatory and antipyretic activity. The mechanism of action is associated with inhibition of COX and inhibition of prostaglandin synthesis. Inhibits platelet aggregation.

Pharmacokinetics

After oral administration, it is well and completely absorbed from the gastrointestinal tract. Cmax is reached after 1.5 hours. The connection with plasma proteins is more than 90%. It is metabolized in the liver. T1 / 2 about 6 hours. Excreted by the kidneys: 20% - unchanged, the rest - in the form of metabolites.

Side effect

From the digestive system: dyspepsia (nausea, vomiting, heartburn, diarrhea), NSAID-gastropathy, abdominal pain, abnormal liver function; with prolonged use in large doses - ulceration of the gastrointestinal tract mucosa, bleeding (gastrointestinal, hemorrhoidal, from the gums). From the side of the cardiovascular system: increased blood pressure, tachycardia, heart failure. From the hematopoietic system: rarely - anemia (iron deficiency, hemolytic, aplastic), agranulocytosis, leukopenia, thrombocytopenia. From the side of the central nervous system and peripheral nervous system: headache, dizziness, drowsiness or insomnia, asthenia, depression, amnesia, tremor, agitation, rarely - ataxia, paresthesia, impaired consciousness. From the urinary system: tubulointerstitial nephritis, edema syndrome, impaired renal function.Allergic reactions: skin rash, itching, urticaria, bronchospasm, photosensitivity, Quincke's edema, anaphylactic shock.

Others: hearing loss, tinnitus, increased sweating.

Application during pregnancy and lactation

Flurbiprofen is contraindicated during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Contraindicated in liver failure.

Application for impaired renal function

Contraindicated in chronic renal failure.

Application in children

Contraindicated in early childhood.

special instructions

Use with caution in congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes). Flurbiprofen can increase bleeding time, which increases the risk of gastrointestinal bleeding, especially with prolonged use. The greatest therapeutic effect is achieved when flurbiprofen is taken in the morning and evening hours. While taking flurbiprofen, periodic monitoring of the peripheral blood picture and bleeding time is necessary. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.When using the drug, cases of delayed scarring of wounds are possible, as well as cross-sensitivity to acetylsalicylic acid and other NSAIDs.

Influence on the ability to drive vehicles and use mechanisms

During treatment, one should refrain from engaging in potentially hazardous activities that require increased attention and speed of mental and motor reactions.

Drug interactions

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites. With the simultaneous use of flurbiprofen reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants (increases the risk of bleeding), antiplatelet agents, fibrinolytics, side effects of mineralocorticoids, corticosteroids, estrogens; reduces the effectiveness of antihypertensive and diuretics; enhances the hypoglycemic effect of sulfonylurea derivatives. Acetylsalicylic acid increases the concentration of the drug in plasma, ranitidine - reduces. Antacids and cholestyramine reduce the absorption of flurbiprofen. With the simultaneous use of flurbiprofen increases the concentration in the blood of lithium preparations, methotrexate.