Quentiax tablets 100mg, No. 60
Expiration Date: 05/2027
Russian Pharmacy name:
Квентиакс таблетки 100мг, №60
treatment of acute and chronic psychoses, including schizophrenia;
treatment of manic episodes in bipolar disorder.
Inside, 2 times a day, regardless of food intake.
Treatment of acute and chronic psychoses, including schizophrenia. The daily dose in the first 4 days is: 1st day - 50 mg; 2nd day - 200 mg; 3rd day - 200 mg and 4th day - 300 mg. Starting from the fourth day, the daily dose is 300 mg. Depending on the clinical effect and tolerability of the drug, its dose can individually vary from 150 to 750 mg / day. The maximum daily dose for the treatment of schizophrenia is 750 mg.
Treatment of manic episodes in bipolar disorder. Quetiapine is recommended as monotherapy or as adjuvant therapy to stabilize mood. The daily dose in the first 4 days is: 1st day - 100 mg; 2nd day - 200 mg; 3rd day - 300 mg and 4th day - 400 mg. An increase in the daily dose in the future is possible at 200 mg / day, and by the 6th day of therapy it is 800 mg. Depending on the clinical effect and tolerability of the drug, its dose can individually vary from 200 to 800 mg / day. Typically, the effective dose is 400 to 800 mg / day. The maximum daily dose for this indication is 800 mg.
Elderly age. Because plasma clearance of quetiapine in the elderly is reduced by 30-50%, the drug should be prescribed with caution, especially at the beginning of therapy. The starting dose is 25 mg / day, followed by an increase of 25-50 mg until the effective dose is reached.
Renal and hepatic impairment. In patients with renal and hepatic insufficiency, it is recommended to start therapy with 25 mg / day. In the future, it is recommended to increase the dose daily by 25-50 mg until the effective dose is reached.
| Film-coated tablets | 1 tab. |
| core | |
| active substance: | |
| quetiapine fumarate (quetiapine hemifumarate) | 28.78 mg |
| 115.13 mg | |
| 172.69 mg | |
| 230.26 mg | |
| 345.39 mg | |
| (equivalent to 25, 100, 150, 200 and 300 mg quetiapine, respectively) | |
| excipients: lactose monohydrate - 4.5 / 18/27/36/54 mg; calcium hydrogen phosphate dihydrate - 2.5 / 10/15/20/30 mg; MCC - 18.97 / 75.87 / 113.81 / 151.74 / 227.61 mg; povidone - 1.25 / 5 / 7.5 / 10/15 mg; sodium carboxymethyl starch (type A) - 5/20/30/40/60 mg; magnesium stearate - 1.5 / 6/9/12/18 mg | |
| film shell: hypromellose - 1.25 / 5 / 7.5 / 10/15 mg; titanium dioxide (E171) - 0.425 / 1.85 / 3/4/6 mg; macrogol 4000 - 0.2 / 1 / 1.5 / 2/3 mg; iron dye yellow oxide (E172) - 0.075 / 0.15 / - / - / - mg; iron dye oxide red (E172) - 0.05 / - / - / - / - mg |
hypersensitivity to quetiapine or other components of the drug;
breastfeeding period;
children and adolescents under 18 years of age (efficacy and safety have not been established).
With caution: patients with cardiovascular and cerebrovascular diseases or other conditions predisposing to arterial hypotension, congenital increase in the QT interval on the electrocardiogram (ECG), or in the presence of conditions that potentially cause an increase in the QT interval (concomitant administration of drugs that prolong the QT interval, congestive heart failure , hypokalemia, hypomagnesemia), old age, liver failure, epilepsy, a history of seizures, pregnancy.