Pyrazidol tablets 50mg, No. 50

• depression of various origins, mainly with psychomotor retardation and asthenic disorders, anxiety-depressive or anxious-delusional components;

• senile, involutional depression;

• alcohol withdrawal syndrome;

• Alzheimer's disease (as part of complex therapy).

The drug is prescribed at an initial dose of 50-75 mg / day, divided into 2 doses. Then the dose is gradually increased by 25-50 mg to 150-300 mg / day. The maximum daily dose is 400 mg. Frequency rate of admission - 2-3 times / day.

After reaching the therapeutic effect, the drug is continued to be used in an individually selected dose for 2-4 weeks. Then the dose is gradually reduced.

Active substance: pirlindol;

Excipients: milk sugar; potato starch; calcium stearate

• acute hepatitis;

• blood diseases;

• simultaneous administration of MAO inhibitors and a period up to 14 days after their cancellation;

• hypersensitivity to the components of the drug.

pharmachologic effect

Antidepressant. It combines a thymoleptic effect with a balanced effect on the central nervous system, while the activating effect on patients with apathetic, anergic depression is combined with a sedative effect in patients in an agitated state.

Selectively, transiently and reversibly inhibits MAO type A; to a high degree blocks the deamination of serotonin and norepinephrine, to a lesser extent - tyramine. Partially inhibits the reuptake of monoamines. Activates the processes of synaptic transmission of nervous excitement in the central nervous system.

Weakens the depressive effects of reserpine, potentiates the effects of the precursor of norepinephrine - dioxyphenylalanine (L-dopa), stimulates adrenergic structures; potentiates the effects of the serotonin precursor 5-hydroxytryptophan (stimulates serotonergic structures).

Has no anticholinergic effect. It has a nootropic effect, improves cognitive functions.

Pharmacokinetics

Data on the pharmacokinetics of the drug Pyrazidol are not provided.

Indications of the drug PyrazidolЃ

• depression of various origins, mainly with psychomotor retardation and asthenic disorders, anxiety-depressive or anxious-delusional components;

• senile, involutional depression;

• alcohol withdrawal syndrome;

• Alzheimer's disease (as part of complex therapy).

  Side effect

  From the digestive system: dry mouth, nausea.

  From the side of the central nervous system and peripheral nervous system: tremor, dizziness.

  Others: sweating, tachycardia, allergic reactions.

  Contraindications for use

  • acute hepatitis;

  • blood diseases;

  • simultaneous administration of MAO inhibitors and a period up to 14 days after their cancellation;

  • hypersensitivity to the components of the drug.

  Application during pregnancy and lactation

  There have been no adequate and strictly controlled studies on the safety and efficacy of the drug during pregnancy and lactation.

  Application for violations of liver function

  The drug is contraindicated in acute hepatitis.

  special instructions

  Pyrazidol is not prescribed simultaneously with antidepressants-MAO inhibitors, furazolidone, procarbazine, selegiline.

  It is possible to use Pyrazidol in patients with glaucoma and benign prostatic hyperplasia.

  Pyrazidol is compatible with antipsychotics, anxiolytics.

  Overdose

  Data on an overdose of the drug Pyrazidol were not provided.

  Drug interactions

  With simultaneous use, it increases the effectiveness of epinephrine (due to antimonoamine oxidase activity).