Pyobacteriophage complex solution, 100ml

Treatment and prevention of pyoinflammatory and intestinal diseases caused by staphylococci, enterococci, streptococci, Pseudomonas aeruginosa, Klebsiella, pathogenic E. coli of various serogroups, Proteus for internal, rectal and external use: diseases of the ear, throat, nose, respiratory tract and lungs:

• inflammation of the sinuses of the nose, middle ear, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;

• surgical infections: wound suppuration, burns, abscess, phlegmon, boils, carbuncles, hydroadenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis;

• urogenital infections: urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingo-oophoritis; post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcers and iridocyclitis;

• enteric infections: gastroenterocolitis, cholecystitis, dysbiosis;

• generalized septic diseases; purulent-inflammatory diseases of newborns: omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.;

• other diseases caused by bacteria staphylococci, streptococci, enterococci, proteus, Klebsiella pneumonia and oxytoca, Pseudomonas aeruginosa and Escherichia coli.

• For prophylactic purposes, the drug is used for the treatment of operating and freshly infected wounds, as well as for the prevention of nosocomial infections for epidemic indications. An important condition for effective phage therapy is a preliminary determination of the phage sensitivity of the pathogen.

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by mouth, for 7-20 days (according to clinical indications).

Depending on the nature of the focus of infection, the bacteriophage is used:

1. Topically in the form of irrigation, lotions and packing with liquid phage in an amount of up to 200 ml, depending on the size of the affected area. In case of abscesses, a bacteriophage is injected into the cavity of the focus after removal of pus by puncture. The amount of injected drug should be slightly less than the volume of removed pus. In osteomyelitis, after appropriate surgical treatment, a bacteriophage is poured into the wound, 10-20 ml each.

2. Introduction into cavities - pleural, articular and other limited cavities up to 100 ml of bacteriophage, after which a capillary drainage is left, through which the bacteriophage is reintroduced within several days.

3. For cystitis, pyelonephritis, urethritis, the drug is taken orally. If the cavity of the bladder or renal pelvis is drained, the bacteriophage is injected through the cystostomy or nephrostomy 1-2 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis.

4. In case of purulent-inflammatory gynecological diseases, the drug is injected into the cavity of the vagina and uterus in a dose of 5-10 ml once daily.

5. For purulent-inflammatory diseases of the ear, throat, nose, the drug is administered in a dose of 2-10 ml 1-3 times a day. The bacteriophage is used for rinsing, washing, instilling, introducing moistened turundas (leaving them for 1 hour).

6. For conjunctivitis and keratoconjunctivitis, the drug is instilled 2-3 drops 4-5 times / day, for purulent corneal ulcers - 4-5 drops, for purulent iridocyclitis, the drug is used 6-8 drops every 3 hours in combination with oral administration.

7. In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of rinsing the mouth 3-4 times a day at a dose of 10-20 ml, as well as injecting turunda impregnated with pyobacteriophage into the periodontal pockets for 5-10 minutes.

8. In case of intestinal forms of the disease, diseases of internal organs, dysbiosis, bacteriophage is used by mouth and in an enema. Through the mouth, the bacteriophage is given 3 times / day on an empty stomach 1 hour before meals. In the form of enemas, it is prescribed 1 time / day instead of one dose through the mouth.

The use of bacteriophages does not exclude the use of other antibacterial drugs. If chemical antiseptics were used to treat wounds prior to using the bacteriophage, the wound should be thoroughly washed with a sterile 0.9% sodium chloride solution.

The use of a bacteriophage in children (up to 6 months). With sepsis, enterocolitis of newborns, including premature babies, bacteriophage is used in the form of high enemas (through a gas tube or catheter) 2-3 times a day (see table). In the absence of vomiting and regurgitation, the drug may be administered by mouth. In this case, it is mixed with breast milk. A combination of rectal (in enemas) and oral (through the mouth) administration of the drug is possible. The course of treatment is 5-15 days. With a recurrent course of the disease, repeated courses of treatment are possible. In order to prevent sepsis and enterocolitis in case of intrauterine infection or the risk of nosocomial infection in newborns, bacteriophage is used in the form of enemas 2 times a day for 5-7 days.

In the treatment of omphalitis, pyoderma, infected wounds, the drug is used as applications twice daily (a gauze napkin is moistened with a bacteriophage and applied to the umbilical wound or to the affected area of ??the skin).

Oral and topical solution

1 fl. a mixture of sterile filtrates of phagolysates of staphylococci, streptococci, enterococci, Proteus, Klebsiella (pneumonia and oxytoca), Pseudomonas aeruginosa and Escherichia coli 100 ml

Preservative: quinosole 0.0001 g / ml

Individual intolerance

pharmachologic effect

Complex liquid pyobacteriophage has the ability to specifically lyse bacteria of staphylococci, streptococci, enterococci, Proteus, Klebsiella pneumonia and oxytoca, Pseudomonas aeruginosa and Escherichia coli.

Side effect

Not installed.

Application during pregnancy and lactation

It is possible to use the drug during pregnancy and during breastfeeding if indicated.

Application in children

Application is possible according to the dosage regimen.

Use in elderly patients

Application is possible according to the dosage regimen.

special instructions

Shake the bottle with liquid bacteriophage before use. If cloudy, do not use! Influence on the ability to drive vehicles and control mechanisms There is no information on the possible effect of the drug on the ability to drive vehicles and mechanisms.

Overdose

Measures to manage overdose have not been established.

Drug interactions

The use of the drug is possible in combination with other drugs, incl. with antibiotics.