Protargol powder for solution preparation 200mg, 10ml

• symptomatic therapy of acute nasopharyngitis, sinusitis;

• acute rhinitis

Topically in the form of a 2% solution.

Method of preparation of 2% solution:

1. Place one Protargol tablet in a dark glass bottle.

2. Pour into the bottle 10 ml (up to the level of the 'shoulders' - the bottleneck) of boiled water (pre-cooled to room temperature) or water for injection.

3. Close the bottle with a pipette cap, shake vigorously for 5 minutes, then leave for 10 minutes and then shake vigorously again for 5 minutes. The tablet should dissolve completely.

Store the prepared solution for no more than 30 days in a dark place at a temperature not exceeding 25 ? C.

Before using Protargol, it is recommended to rinse and cleanse the nasal passages.

Adults and children over 6 years old, 2-3 drops in each nasal passage 3 times a day

Children from 3 to 6 years old: 1-2 drops in each nasal passage 3 times a day for 5-7 days.

The main effect of the drug will appear only 2-3 days after the first use.

If symptoms persist or worsen for more than 5-7 days, it is recommended to consult a doctor. Use the drug only according to the method of administration and in those doses indicated in the instructions for use.

If necessary, please consult your doctor before using this medication.

Tablets for the preparation of a solution for topical application from brown to dark brown or almost black in color with a bluish tinge, heterogeneity of staining is allowed, round, flat-cylindrical, with a chamfer and risk.

1 tab. silver proteinate (protargol) 200 mg

Excipients: hydroxypropyl methylcellulose - 10 mg.

• hypersensitivity to the agent;

• pregnancy, breastfeeding period;

• atrophic rhinitis;

• children up to age 3 years.

pharmachologic effect

Silver based product (silver proteinate contains 7.5-8.5% silver). It has an astringent, antiseptic and anti-inflammatory effect. Dissociates to form silver ions, which bind to bacterial DNA and prevent them from multiplying on mucous membranes under conditions of topical application. The mechanism of action of silver proteinate is based on the fact that silver ions precipitate proteins and form a protective film on the damaged mucous membrane, which helps to reduce the sensitivity of nerve endings and narrowing of blood vessels (this leads to a decrease in edema), which in turn causes inhibition of inflammatory reactions. Silver ions also inhibit the growth of various bacteria. Active against gram-positive and gram-negative microorganisms: B. cereus, C. albicans, E. coli, P. aeruginosa, S. aureus, A. niger,S. Abony et al.

Side effect

Possibly: slight irritation of the mucous membrane, burning, itching, allergic reactions (urticaria, atopic dermatitis, Quincke's edema, anaphylactic shock)

Application during pregnancy and lactation

Use during pregnancy and breastfeeding is contraindicated.

Application in children

Use in children under 3 years of age is contraindicated.

special instructions

It is possible to stain the discharge from the nose in gray or blue.

Drug interactions

Salts of zinc, copper, lead, silver, mercury, iron, aluminum form insoluble precipitates with silver proteinate in the form of a solution.

Silver proteinate is inactivated by alkaloid salts, epinephrine.