Proproten - 100 lozenges, No. 40

Shows anti-alcoholic effects, reducing craving for alcohol and reducing the likelihood of relapses.
Monotherapy for mild to moderate alcohol withdrawal symptoms. The drug relieves both psychopathological disorders (anxiety, mental stress, insomnia, irritability, anxiety, decreased mood, intense craving for alcohol) and somatovegetative disorders (weakness, sweating, headache, tremors, tachycardia, digestive disorders) of alcoholic hangover syndrome ...

At one time - keep 1 tablet in your mouth until it is completely dissolved - (not during a meal).
In a state of a hangover, for the first 2 hours, the drug is taken 1 tablet every 30 minutes; the next 8 - 10 hours - 1 tablet per hour. In case of sleep onset, the reception is resumed after waking up.
In the future, when the condition improves, the drug is taken 1 tablet every 2-3 hours (4-6 tablets per day) for 2-3 days.
When the symptoms of alcohol withdrawal are aggravated, it is necessary to add drugs traditionally used in detoxification.
For the prevention of relapses, the drug is taken 1-2 tablets per day for 2-3 months; after accidentally drinking alcohol, take an additional 2 tablets of the drug 2 times - during the day and at night.

Active ingredients:

affinity purified antibodies to brain-specific protein S-100 - 0.003 g *.

Excipients: lactose, microcrystalline cellulose, magnesium stearate.

* are introduced in the form of a water-alcohol mixture of the active form of the active substance1
1 The active form of the active substance is the active form with a content of no more than 10-1991 ng / g of the active substance.

Increased individual sensitivity to the components of the drug, pregnancy and lactation.

Dosage form:

lozenges

Composition
Active ingredients:

affinity purified antibodies to brain-specific protein S-100 - 0.003 g *.

Excipients: lactose, microcrystalline cellulose, magnesium stearate.

* are introduced in the form of a water-alcohol mixture of the active form of the active substance1
1 The active form of the active substance is the active form with a content of no more than 10-1991 ng / g of the active substance.

Description
Tablets of a flat-cylindrical shape, with a score and a chamfer, from white to almost white. The flat, scribbled side has the inscription MATERIA MEDICA, the other flat side has the inscription PROPROTEN 100.

Pharmacotherapeutic group
Alcoholism means of treatment.

Pharmacological action
The drug modifies the functional activity of the S-100 protein, which carries out the conjugation of information and metabolic processes in the brain. Sensitizes the neuronal membrane, modulates the synaptic plasticity of neurons. It has a modifying effect on the functional state of brain structures involved in the formation of alcohol dependence: hypothalamus, hippocampus, etc.
With alcohol dependence, it has a normalizing effect on the system of positive emotional reinforcement, which leads to a decrease in the frequency of self-stimulation of the lateral hypothalamus. Reduces the bursting activity of hippocampal neurons; reduces the number of circulating immune complexes in the peripheral blood, which correlates with a decrease in ethanol consumption. It enhances the inhibitory effects of GABA in the central nervous system. It has been experimentally established that the drug restores the neurotransmitter balance and conditioned reflex activity. Increases the brain's resistance to hypoxia and toxic effects.

Indications for use
Shows an anti-alcohol effect, reducing the craving for alcohol and reducing the likelihood of relapses.
Monotherapy for mild to moderate alcohol withdrawal symptoms. The drug relieves both psychopathological disorders (anxiety, mental stress, insomnia, irritability, anxiety, decreased mood, intense craving for alcohol) and somatovegetative disorders (weakness, sweating, headache, tremors, tachycardia, digestive disorders) of alcoholic hangover syndrome ...

Contraindications
Increased individual sensitivity to the components of the drug, pregnancy and lactation.

Method of administration and dosage
At one time - keep 1 tablet in the mouth until it is completely dissolved - (not during a meal).
In a state of hangover, the first 2 hours, the drug is taken 1 tablet every 30 minutes; the next 8 - 10 hours - 1 tablet per hour. In case of sleep onset, the reception is resumed after waking up.
In the future, when the condition improves, the drug is taken 1 tablet every 2-3 hours (4-6 tablets per day) for 2-3 days.
When the symptoms of alcohol withdrawal are aggravated, it is necessary to add medications traditionally used in detoxification.
For the prevention of relapses, the drug is taken 1-2 tablets per day for 2-3 months; after accidental consumption of alcohol, take an additional 2 tablets of the drug 2 times - during the day and at night.

Side effect
Possible reactions of increased individual sensitivity to the components of the drug.

Overdose
In case of an accidental overdose, dyspeptic symptoms are possible due to the fillers included in the preparation.

Interaction with other medicinal products
No cases of incompatibility with other medicinal products have been identified to date.

Special instructions
The composition of the drug includes lactose, and therefore it is not recommended to prescribe it to patients with congenital galactosemia, glucose malabsorption syndrome, or with congenital lactase deficiency.

Release form
Tablets for resorption. 20 tablets in a blister strip made of polyvinyl chloride film and aluminum foil. 20 or 50 tablets in a polymer jar with a screw neck and a screw-on lid for vitamins and medicines or a polymer jar with a shock absorber and a tightened lid with a first opening control for vitamins and medicines. A label made of label paper is glued to each jar.
1, 2 or 5 blister packs or each can, together with instructions for use, are placed in a cardboard box.

Storage conditions
In a dry, dark place, at C ?. temperature not higher than 25
Keep out of reach of children.

Shelf life is
3 years.
Do not use after the expiration date.

Terms of dispensing from pharmacies
Without prescription.