Proproten - 100 drops for oral administration, 25 ml

Shows anti-alcoholic effects, reducing craving for alcohol and reducing the likelihood of relapse

Monotherapy for mild to moderate alcohol withdrawal symptoms.

The drug relieves both psychopathological disorders (anxiety, mental stress, insomnia, irritability, anxiety, decreased mood, intense craving for alcohol) and somatovegetative disorders (weakness, sweating, headache, tremor, tachycardia, digestive disorders) of alcoholic hangover syndrome ...

At one time - 10 drops in a tablespoon of water (not during meals).

In a state of hangover, in the first 2 hours, the drug is taken 10 drops every 30 minutes; in the next 8-10 hours - 10 drops per hour.

In case of sleep onset, the reception is resumed after waking up.

In the future, when the condition improves, the drug is taken 10 drops every 2-3 hours (4-6 doses per day) for 2-3 days.

When the symptoms of alcohol withdrawal are aggravated, it is necessary to add drugs traditionally used in detoxification.

For the prevention of relapses, the drug is taken 10 drops 1-2 times a day for 2-3 months; after accidentally drinking alcohol, take an additional 10 drops of the drug 2 times - during the day and at night.

Active components: affinity purified antibodies to brain-specific protein S-100 - 1.0 g *.
Excipients: ethyl alcohol (ethanol) 95% (v / v), purified water.

* introduced in the form of a water-alcohol mixture of the active form of the active substance
1 1 The active form of the active substance is the active form with a content of no more than 10-1991 ng / g of the active substance

Increased individual sensitivity to the components of the drug, pregnancy and lactation.

Dosage form:

oral drops

Composition
Active ingredients: antibodies to brain-specific protein S-100 affinity purified - 1.0 g *.
Excipients: ethyl alcohol (ethanol) 95% (v / v), purified water.

* introduced in the form of a water-alcohol mixture of the active form of the active substance
1 1 The active form of the active substance is the active form with a content of no more than 10-1991 ng / g of the active substance

Description
Colorless transparent liquid with a characteristic alcoholic odor.

Pharmacotherapeutic group
Alcoholism means of treatment.

ATX code: N07BB

Pharmacological action
The drug modifies the functional activity of the S-100 protein, which carries out the conjugation of information and metabolic processes in the brain. Sensitizes the neuronal membrane, modulates the synaptic plasticity of neurons. It has a modifying effect on the functional state of brain structures involved in the formation of alcohol dependence: hypothalamus, hippocampus, etc.
With alcohol dependence, it has a normalizing effect on the system of positive emotional reinforcement, which leads to a decrease in the frequency of self-stimulation of the lateral hypothalamus. Reduces the bursting activity of hippocampal neurons; reduces the number of circulating immune complexes in the peripheral blood, which correlates with a decrease in ethanol consumption. It enhances the inhibitory effects of GABA in the central nervous system. It has been experimentally established that the drug restores the neurotransmitter balance and conditioned reflex activity. Increases the brain's resistance to hypoxia and toxic effects.

Indications for use
Shows an anti-alcohol effect, reducing the craving for alcohol and reducing the likelihood of relapses.
Monotherapy for mild to moderate alcohol withdrawal symptoms.
The drug relieves both psychopathological disorders (anxiety, mental stress, insomnia, irritability, anxiety, decreased mood, intense craving for alcohol) and somatovegetative disorders (weakness, sweating, headache, tremors, tachycardia, digestive disorders) of alcoholic hangover syndrome ...

Contraindications
Increased individual sensitivity to the components of the drug, pregnancy and lactation.

Method of administration and dosage
At one time - 10 drops in a tablespoon of water (not during meals).
In a state of hangover, in the first 2 hours, the drug is taken 10 drops every 30 minutes; in the next 8-10 hours - 10 drops per hour.
In case of sleep onset, the reception is resumed after waking up.
In the future, when the condition improves, the drug is taken 10 drops every 2-3 hours (4-6 doses per day) for 2-3 days.
When the symptoms of alcohol withdrawal are aggravated, it is necessary to add medications traditionally used in detoxification.
For the prevention of relapses, the drug is taken 10 drops 1-2 times a day for 2-3 months; after accidentally drinking alcohol, take an additional 10 drops of the drug 2 times - during the day and at night.

Side effect
Possible reactions of individual hypersensitivity to the components of the drug.

Overdose
So far, no cases of overdose have been observed.

Interaction with other medicinal products
No cases of incompatibility with other medicinal products have been identified to date.

Release form
Drops for oral administration. 25 ml in glass bottles of OS brand, sealed with dropper stoppers or blind stoppers (complete with dropper stoppers) and plastic caps with or without first opening control, or imported.
Each bottle, along with instructions for use, is placed in a cardboard box.

Storage conditions
In a dark place at a temperature not exceeding 25 ? C. Keep out of the reach of children.

Shelf life is
2 years.
Do not use after the expiration date.

Terms of dispensing from pharmacies
Without prescription.