Progesterone 2.5% 10ml

DESCRIPTION

Progesterone 2.5% - for the prevention of abortion, barrenness, functional weakness of the genitals, toxicosis of pregnancy in animals. Dosage form: oil solution for injection. In appearance, Progesterone 2.5% is a clear oily liquid of light yellow or golden yellow color.

COMPOSITION

Progesterone 2.5% in 1 ml contains progesterone - 0.025 g as an active ingredient, and benzyl benzoate and olive oil as auxiliary substances.

PHARMACOLOGICAL PROPERTIES

Progesterone 2.5% belongs to the pharmacotherapeutic group of sex hormones and their synthetic analogues.

Progesterone 2.5% refers to progestogen drugs, is a hormone of the corpus luteum. Promotes the transition of the mucous membrane of the uterus from the proliferative phase caused by the follicular hormone to the secretory phase. After fertilization, the egg stimulates its transition to the state necessary for its development.

The drug reduces the excitability and contractility of the fallopian tubes and the muscles of the uterus, has a stimulating effect on the development of the terminal elements of the mammary glands. Progesterone does not possess androgenic activity. It has a weak effect on protein metabolism, promotes the deposition of fats in lipocytes, the accumulation of glucose in the liver and a decrease in sodium reabsorption in the renal tubules. Progesterone blocks the secretion of hypothalamic release factors of FSH and LH, has a depressing effect on the formation of gonadotropic hormones in the pituitary gland, and inhibits ovulation. After intramuscular administration, the drug is almost completely absorbed at a high rate. Progesterone is metabolized in the liver, most of its metabolites form conjugates with sulfuric and glucuronic acids.

Progesterone is excreted in feces (more than 10%) and urine (50-60%). The amount of metabolites excreted in the urine varies depending on the phase in which the corpus luteum is located.

According to the degree of effect on the body, Progesterone 2.5% according to GOST 12.1.007-76 belongs to low-hazard substances (hazard class 4), does not have a local irritant and sensitizing effect.

Progesterone reduces the effectiveness of drugs that act to stimulate the smooth muscles of the uterus, gonadotropic hormones produced by the anterior pituitary gland, and anabolic steroids. Helps to reduce the lactogenic effect of oxytocin. Strengthens the effect of immunosuppressants, antihypertensive drugs and diuretics. There is a decrease in the action of progesterone when used simultaneously with barbiturates.

INDICATIONS

Progesterone 2.5% is used to prevent abortion, barrenness, functional weakness of the genitals, toxicosis of pregnancy.

APPLICATION

Progesterone 2.5% warmed up to a temperature of 37 В° -40 В° C, is administered to animals intramuscularly or subcutaneously once a day for 4-7 days in a row at the rate of 0.025-0.1 g of the active substance.

Doses of the drug (ml per 1 kg of live weight):

Kind of animal Intramuscularly / subcutaneously

Horses 0.01

Cattle 0.01

Small cattle 0.01

Pigs 0.015

Dogs 0.002

In the absence of ovulation and unproductive insemination, Progesterone 2.5% is administered to cows subcutaneously in a dose of 0.5 ml twice with an interval of one day at the beginning of the hunt and in the initial phase of the formation of the corpus luteum.

Avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic effectiveness. If one or more doses are missed, the use of the drug is resumed as soon as possible in the same dosage and according to the same scheme.

SPECIAL INSTRUCTIONS

The use of progesterone during pregnancy is allowed in extreme cases, with diagnosed deficiency in the body of corpus luteum hormones.

Products of animal origin obtained from animals after the use of Progesterone 2.5% are used without restrictions.

CONTRAINDICATIONS

Contraindications for use: increased individual sensitivity to the components of the drug, impaired renal and liver function, diseases of the cardiovascular system.

OVERDOSE

In case of an overdose of the drug, the animal may experience edema, impaired liver function, jaundice. In these cases, the drug is canceled and the animal is prescribed specific and symptomatic therapy.

SIDE EFFECTS

There were no side effects and complications when using Progesterone 2.5% in accordance with this instruction.

PRECAUTIONS

When working with Progesterone 2.5%, you should follow the general rules of personal hygiene and safety measures provided for when working with drugs. People with hypersensitivity to the drug components should avoid direct contact with Progesterone 2.5%. It is forbidden to use empty vials from the medicinal product for household purposes; they must be disposed of with household waste.

FIRST AID MEASURES

In case of accidental contact of the drug with the skin or mucous membranes of the eyes, immediately rinse them with plenty of water.

In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for use of the drug and a label with you).

SHELF LIFE AND STORAGE

Store the medicinal product in the manufacturer's sealed packaging, in a dry place protected from direct sunlight, separately from food and feed, at a temperature from + 5 В° C to + 20 В° C. The shelf life of the medicinal product, subject to storage conditions, is 5 years from the date of manufacture. It is prohibited to use Progesterone 2.5% after the expiration date.

PACKAGING

The drug is packaged in 10 ml glass bottles.

Specifications

KolVUP

50

Manufacturer

BioFarmGarant

Temperature regime

from +5 to +20

Teaser

used to prevent abortion, with barrenness, functional weakness of the genitals, toxicosis of pregnancy