Procto-glivenol supp. rekt. No. 10
Category
Hemorrhoids
Scope of the drug
Gastrointestinal tract
Release form
Suppositories
Manufacturer country
France
Package quantity, pcs
ten
Release form, composition and packaging
?
Rectal suppositories are solid, torpedo-shaped, without cracks, slightly greasy to the touch, yellowish-white in color, with a weak specific odor.
1 supp.
tribenoside 400 mg
lidocaine 40 mg
witepsol E85 (suppository n ° 1) - 305 mg, witepsol W35 (suppository n ° 2) - 1255 mg.
5 pieces.
- strips made of combined material (2) - cardboard packs.
pharmachologic effect
Combined anti-hemorrhoidal drug.
Tribenoside reduces capillary permeability and improves vascular tone, antagonistically affects some endogenous substances that act as mediators in the development of inflammation and pain.
Lidocaine has a local anesthetic effect.
The drug causes a rapid relief of symptoms caused by hemorrhoids (pain, itching and skin tightness).
Pharmacokinetics
Absorption The systemic bioavailability of tribenoside from the suppository reaches 30% of the amount absorbed when the drug is taken orally.
After rectal administration of 1 suppository (400 mg), Cmax of tribenoside in blood plasma is achieved after 2 hours and is 1 μg / ml (tribenoside + metabolites).
Metabolism Tribenoside is extensively metabolized in the liver.
Excretion 20-27% of the dose is excreted in the urine as metabolites.
Indications for use
- external and internal hemorrhoids.
Contraindications for use
- hypersensitivity to drug components
- liver failure
- I trimester of pregnancy.
Dosage regimen
Rectally.
With severe clinical symptoms, 1 suppository is administered in the morning and in the evening.
With regression of acute symptoms - 1 suppository 1 time / day.
Overdose
Cases of drug overdose have not been registered.
In case of accidental ingestion, gastrointestinal lavage is recommended, as well as symptomatic supportive therapy.
Side effect
From the immune system: very rarely (< 1/10 000) - anaphylactic reactions, including angioedema, facial edema, bronchospasm and cardiovascular disorders.
Skin and subcutaneous tissue disorders: rarely (> 1/10 000, < 1/1 000) - skin reactions at the site of application (burning, rash, itching and urticaria).
These symptoms can spread beyond the site of application.
Drug interactions
No interactions have been reported.
Application during pregnancy and lactation
Use in the first trimester of pregnancy is contraindicated. When using the drug in the II and III trimesters of pregnancy, the possible risk to the fetus must be taken into account. If it is necessary to use the drug during breastfeeding, the expected benefits of therapy for the mother and the potential risk for the child should be weighed.
If the existing symptoms of the disease do not diminish in the course of treatment or if new unusual sensations appear, consult a doctor.
When using Procto-Glivenol®, it is necessary to monitor the hygiene of the anal area, avoid excessive stress, and take measures to maintain a soft stool consistency.
Influence on the ability to drive vehicles and mechanisms When used in doses not exceeding the recommended ones, the drug has no effect on the ability to perform work associated with the need for concentration of attention, quick mental and motor reactions.
Name ENG
PROCTO-GLYVENOL
Clinical and pharmacological group
A drug with venotonic, anti-inflammatory and local anesthetic action for local use in proctology
ATX code
Other drugs and their combinations
Dosage
40mg + 400mg
Structure
Active ingredients: tribenoside 400 mg
lidocaine 40 mg
Storage conditions and periods
At a temperature not higher than 30 degrees.
Expiration date: 5 years
INN / Active ingredient
lidocaine, tribenoside
Specifications
Category
Hemorrhoids
Scope of the drug
Gastrointestinal tract
Release form
Suppositories
Manufacturer country
France
Package quantity, pcs
ten
Way of introduction
Rectally
Vacation conditions
Without recipe
Brand name
Recordati Industria Chimica & Farmaceutica
The amount of the dosage form in the primary package
5 pieces.
Primary packaging type
Cell-free contoured packaging (strip)
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Hemorrhoid remedy
Dosage form
Rectal suppositories
Expiration date in days
1825
Dosage (volume) of the substance in the preparation
tribenoside - 400 mg
lidocaine - 40 mg.
The target audience
Children
Package weight, g
fifty
Mode of application
:
Rectally.
Until acute symptoms disappear - 1 suppository or 1 dose of cream 2 times a day (morning and evening)
then the dose can be reduced and the drug should be administered once a day.
30 g of cream is enough for about 20-30 applications.
Anatomical and therapeutic characteristics
:
C05AX03 Preparations for the treatment of hemorrhoids and anal fissures in combination