potassium and magnesium asparahynat | Panangin Forte tablets 316 mg + 280 mg 60 pcs.
Special Price
$19.40
Regular Price
$28.00
In stock
SKU
BID480759
Release form
Tablets.
Tablets.
Release form
Tablets.
Packing
60 pcs.
Pharmacological action of
Pharmacodynamics of
The most important intracellular cations of potassium (K +) and magnesium (Mg ++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium, and magnesium ions affects myocardial contractility.
Endogenous asparaginate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium asparaginate and potassium asparaginate improve myocardial metabolism. A lack of magnesium / potassium predisposes to the development of arterial hypertension, coronary artery atherosclerosis, arrhythmias and metabolic changes in the myocardium.
Each tablet of the Panangin Forte preparation contains 280 mg of magnesium asparaginate and 316 mg of potassium asparaginate, which is 2 times the content of active substances in the preparation Panangin®, film-coated tablets.
Daily dose of Panangin® Forte: 1 tablet 3 times a day, corresponds to a daily dose of Panangin®: 2 tablets 3 times a day. Taking a single dose of Panangin Forte in a single tablet makes the treatment more convenient for the patient.
Pharmacokinetics
Potassium and magnesium asparaginates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys.
Indications
To eliminate potassium and magnesium deficiency in combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction) of chronic heart failure, cardiac arrhythmias (including arrhythmias caused by overdose of cardiac glycosides).
Contraindications
Hypersensitivity to any of the components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm) , metabolic acid disturbance, severe myasthenia gravis, hemolysis, acute metabolic acidosis, state of dehydration, age up to 18 years (effectiveness and safety have not been established).
Use during pregnancy and lactation
Use is possible if the potential benefit to the mother outweighs the potential risk to the fetus.
Potassium and magnesium asparaginate pass into breast milk.
If you need to take the drug during lactation, breastfeeding must be stopped.
Special instructions
Particular attention is required for patients with diseases accompanied by hyperkalemia: regular monitoring of potassium in the blood plasma is necessary.
Effects on ability to drive vehicles and mechanisms
No studies were conducted. It is not expected to affect the ability to drive vehicles and work with mechanisms that require an increased concentration of attention and speed of psychomotor reactions.
Composition of
Per tablet:
Core of the tablet
Active ingredients:
potassium asparaginate 316.00 mg (potassium asparaginate hemihydrate 332.60 mg),
magnesium asparaginate 280.00 mg (magnesium tetragidate 350 mg) mg)
Excipients:
corn starch 172.20 mg,
talcum 20.00 mg,
magnesium stearate 8.00 mg,
potato starch 6.60 mg,
povidone KZO 6.60 mg,
4 silicon dioxide , 00 mg
Tablet shell:
talcum 7.30 mg,
butyl methacrylate copolymer 6.00 mg,
titanium dioxide (color index with: CI 77891, E171) 5.30 mg,
macrogol 6000 1.40 mg.
Dosage and administration
Before use, consult your doctor.
Inside, without chewing and drinking plenty of water.
Panangin Forte should be taken after meals, as the acidic environment of the stomach reduces its effectiveness.
Recommended daily dose: 1 tablet 3 times a day.
Maximum daily dose: 1 tablet 3 times a day.
Side effects
Possible nausea, vomiting, diarrhea, unpleasant sensations or burning in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increase in the number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (facial flushing, feeling of thirst, decrease in arterial pressure, decrease in arterial pressure) hyporeflexia, respiratory depression, convulsions).
If any of the following adverse reactions become serious, or you notice the occurrence of adverse reactions not listed in this manual, you should consult a doctor.
Drug interactions
Pharmacodynamic interactions
When used together with potassium-sparing diuretics (triamteren, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme inhibitors and developmental hypertrophic hypertrophy and anti-inflammatory syndromes and hypertrophic hypertrophy, anemia, and hypertrophic hypertrophy.
The simultaneous use of potassium preparations with glucocorticosteroids eliminates the hypokalemia caused by the latter. Potassium reduces the unwanted effects of cardiac glycosides. Panangin® Forte enhances the negative dromo- and batmotropic effects of antiarrhythmic drugs.
Magnesium reduces the effects of neomycin, polymyxin B, tetracycline, and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system while the use of atracuronium, decametonium, succinyl chloride and suxamethonium may increase neuromuscular blockade. Calcitriol increases the content of magnesium in blood plasma, calcium preparations reduce the effects of magnesium preparations.
Pharmacokinetic interaction
Drugs possessing an astringent and enveloping effect, reduce the absorption of magnesium asparaginate and potassium asparaginate in the gastrointestinal tract, therefore, it is necessary to observe the three-hour interval between ingestion of Panangin® Forte with the above drugs.
Overdose
Increases the risk of symptoms of hyperkalemia and hypermagnesemia.
Symptoms of hyperkalemia: increased fatigue, myasthenia paralysis, paresthesia, confusion, cardiac arrhythmias (bradycardia, atrioventricular blockade, arrhythmias, cardiac arrest).
Symptoms of hypermagnesemia: decrease in neuromuscular excitability, nausea, vomiting, lethargy, decrease in blood pressure.
With a sharp increase in the content of magnesium ions in the blood: suppression of deep tendon reflexes, paralysis of breathing, coma.
Treatment: symptomatic therapy - intravenous administration of calcium chloride at a dose of 100 mg / min, if necessary - hemodialysis.
Storage Conditions
At a temperature not exceeding 30 РC.
Keep out of the reach and sight of children!
Shelf life
2 years.
Deystvuyushtee substance
Kalia and magnesium asparaginate
Terms and conditions
without prescription
Dosage form
tablets
Possible product names
Panangin Forte tablets 60 pcs.
Gideon Richter, Vengriya
Tablets.
Packing
60 pcs.
Pharmacological action of
Pharmacodynamics of
The most important intracellular cations of potassium (K +) and magnesium (Mg ++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium, and magnesium ions affects myocardial contractility.
Endogenous asparaginate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium asparaginate and potassium asparaginate improve myocardial metabolism. A lack of magnesium / potassium predisposes to the development of arterial hypertension, coronary artery atherosclerosis, arrhythmias and metabolic changes in the myocardium.
Each tablet of the Panangin Forte preparation contains 280 mg of magnesium asparaginate and 316 mg of potassium asparaginate, which is 2 times the content of active substances in the preparation Panangin®, film-coated tablets.
Daily dose of Panangin® Forte: 1 tablet 3 times a day, corresponds to a daily dose of Panangin®: 2 tablets 3 times a day. Taking a single dose of Panangin Forte in a single tablet makes the treatment more convenient for the patient.
Pharmacokinetics
Potassium and magnesium asparaginates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys.
Indications
To eliminate potassium and magnesium deficiency in combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction) of chronic heart failure, cardiac arrhythmias (including arrhythmias caused by overdose of cardiac glycosides).
Contraindications
Hypersensitivity to any of the components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm) , metabolic acid disturbance, severe myasthenia gravis, hemolysis, acute metabolic acidosis, state of dehydration, age up to 18 years (effectiveness and safety have not been established).
Use during pregnancy and lactation
Use is possible if the potential benefit to the mother outweighs the potential risk to the fetus.
Potassium and magnesium asparaginate pass into breast milk.
If you need to take the drug during lactation, breastfeeding must be stopped.
Special instructions
Particular attention is required for patients with diseases accompanied by hyperkalemia: regular monitoring of potassium in the blood plasma is necessary.
Effects on ability to drive vehicles and mechanisms
No studies were conducted. It is not expected to affect the ability to drive vehicles and work with mechanisms that require an increased concentration of attention and speed of psychomotor reactions.
Composition of
Per tablet:
Core of the tablet
Active ingredients:
potassium asparaginate 316.00 mg (potassium asparaginate hemihydrate 332.60 mg),
magnesium asparaginate 280.00 mg (magnesium tetragidate 350 mg) mg)
Excipients:
corn starch 172.20 mg,
talcum 20.00 mg,
magnesium stearate 8.00 mg,
potato starch 6.60 mg,
povidone KZO 6.60 mg,
4 silicon dioxide , 00 mg
Tablet shell:
talcum 7.30 mg,
butyl methacrylate copolymer 6.00 mg,
titanium dioxide (color index with: CI 77891, E171) 5.30 mg,
macrogol 6000 1.40 mg.
Dosage and administration
Before use, consult your doctor.
Inside, without chewing and drinking plenty of water.
Panangin Forte should be taken after meals, as the acidic environment of the stomach reduces its effectiveness.
Recommended daily dose: 1 tablet 3 times a day.
Maximum daily dose: 1 tablet 3 times a day.
Side effects
Possible nausea, vomiting, diarrhea, unpleasant sensations or burning in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increase in the number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (facial flushing, feeling of thirst, decrease in arterial pressure, decrease in arterial pressure) hyporeflexia, respiratory depression, convulsions).
If any of the following adverse reactions become serious, or you notice the occurrence of adverse reactions not listed in this manual, you should consult a doctor.
Drug interactions
Pharmacodynamic interactions
When used together with potassium-sparing diuretics (triamteren, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme inhibitors and developmental hypertrophic hypertrophy and anti-inflammatory syndromes and hypertrophic hypertrophy, anemia, and hypertrophic hypertrophy.
The simultaneous use of potassium preparations with glucocorticosteroids eliminates the hypokalemia caused by the latter. Potassium reduces the unwanted effects of cardiac glycosides. Panangin® Forte enhances the negative dromo- and batmotropic effects of antiarrhythmic drugs.
Magnesium reduces the effects of neomycin, polymyxin B, tetracycline, and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system while the use of atracuronium, decametonium, succinyl chloride and suxamethonium may increase neuromuscular blockade. Calcitriol increases the content of magnesium in blood plasma, calcium preparations reduce the effects of magnesium preparations.
Pharmacokinetic interaction
Drugs possessing an astringent and enveloping effect, reduce the absorption of magnesium asparaginate and potassium asparaginate in the gastrointestinal tract, therefore, it is necessary to observe the three-hour interval between ingestion of Panangin® Forte with the above drugs.
Overdose
Increases the risk of symptoms of hyperkalemia and hypermagnesemia.
Symptoms of hyperkalemia: increased fatigue, myasthenia paralysis, paresthesia, confusion, cardiac arrhythmias (bradycardia, atrioventricular blockade, arrhythmias, cardiac arrest).
Symptoms of hypermagnesemia: decrease in neuromuscular excitability, nausea, vomiting, lethargy, decrease in blood pressure.
With a sharp increase in the content of magnesium ions in the blood: suppression of deep tendon reflexes, paralysis of breathing, coma.
Treatment: symptomatic therapy - intravenous administration of calcium chloride at a dose of 100 mg / min, if necessary - hemodialysis.
Storage Conditions
At a temperature not exceeding 30 РC.
Keep out of the reach and sight of children!
Shelf life
2 years.
Deystvuyushtee substance
Kalia and magnesium asparaginate
Terms and conditions
without prescription
Dosage form
tablets
Possible product names
Panangin Forte tablets 60 pcs.
Gideon Richter, Vengriya
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