potassium and magnesium asparahynat | Panangin ampoules, 10 ml, 5 pcs.

release form solution for intravenous administration.

Packaging

In a clear glass ampoule, 10 ml of solution. In a package of 5 ampoules.

Indications

- As part of the complex treatment of heart failure, myocardial infarction, cardiac arrhythmias (mainly ventricular arrhythmias).

- To improve cardiac glycoside tolerance.

Contraindications

- Acute and chronic renal failure.

- Oliguria, anuria.

- Addison's Disease.

- AV blockade II and III degree.

- Cardiogenic shock (blood pressure <90 mmHg).

- Hyperkalemia.

- Hypermagnesemia.

- Hypersensitivity to the drug.

Use during pregnancy and lactation

There are no data on the negative effects of the drug in the form of a solution for iv administration during pregnancy and lactation (breastfeeding).

Composition of

1 ml iv solution contains:

potassium asparaginate 45.2 mg,

magnesium asparaginate 40 mg.

Excipients:

water d / i.

Dosage and administration of

The drug is administered in / drip, in the form of a slow infusion.

Single dose - 1-2 ampoules, if necessary, re-administration after 4-6 hours is possible.

To prepare a solution for iv infusion, the contents are 1-2 amp. dissolved in 50-100 ml of 5% glucose solution.

Side effects of

With rapid on / in the introduction may develop symptoms of hyperkalemia and / or hypermagnesemia.

Drug Interaction

When used with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporin, heparin, ACE inhibitors and NSAIDs, the risk of developing a hyperplasia increases. The use of potassium in conjunction with ACS eliminates their hypokalemia. Under the influence of potassium, a decrease in the undesirable effects of cardiac glycosides is observed.

The drug enhances the negative dromo and bathmotropic effect of antiarrhythmic drugs.

Due to the presence of potassium ions in the preparation of Panangin with ACE inhibitors, beta-blockers, cyclosporine, potassium-sparing diuretics, heparin, NSAIDs may develop hyperkalemia (control of the level of potassium in the blood plasma) with anticholinergic agents - a more pronounced decrease in intestinal peristalsis with cardiac glycosides - reducing their action.

Magnesium drugs reduce the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin.

Anesthetics increase the depressant effect of magnesium on the CNS. With the use of Panangin with atracurium, dexamethonium, saxamethonium, it is possible to increase the neuromuscular blockade with calcitriol - an increase in the level of magnesium in the blood plasma with calcium preparations is observed decrease in the action of magnesium ions.

When used with Panangin with potassium-sparing diuretics and ACE inhibitors, the risk of developing hyperkalemia increases (plasma potassium levels should be monitored).

Overdose

Symptoms: with / in the introduction - hyperkalemia, hypermagnesemia.

Treatment: withdrawal of the drug, carrying out symptomatic therapy (in / in the introduction of 100 mg / min calcium chloride solution), hemodialysis and peritoneal dialysis, if necessary.

Storage conditions

The drug should be stored at a temperature of 15 to 30 РC.

Expiration

3 years.

Deystvuyuschee substances

potassium and magnesium asparahynat



pharmacy terms and conditions prescription

Dosage form

Dosage form

infusion solution