potassium and magnesium asparahynat | Asparkam Renewal tablets 56 pcs.

Release form

Tablets

Packing

56 pcs.

Pharmacological action

The mechanism of action of Asparkam is associated with the effective participation of L-asparaginate in the transport of magnesium and potassium ions into the intracellular space. Magnesium activates sodium-potassium-ATPase, removing sodium ions from the cell and returning potassium ions, reduces the concentration of sodium and prevents its exchange for calcium in the smooth muscles of blood vessels, reducing their resistance. Potassium stimulates the synthesis of ATP, glycogen, proteins, acetylcholine, etc. Both ions support the polarization of cell membranes.

The drug regulates the conduction of impulses along nerve fibers, synaptic transmission, muscle contraction, and cardiac muscle function. Due to magnesium ions, it participates in the processes of energy input and expenditure, normalizes membrane permeability, neuromuscular conductivity, DNA synthesis, RNA, cell growth, cell division, oxygen uptake and phosphate synthesis.

Pharmacokinetics

Potassium and magnesium ions are rapidly absorbed and distributed throughout all body tissues. About 30% of magnesium in plasma forms complex compounds with proteins. The excretion of potassium and magnesium occurs mainly with urine, in small quantities with feces, sweat, tears, etc. With renal failure, the excretion of potassium and magnesium ions can slow down.

Indications

To eliminate potassium and magnesium deficiency

as an adjuvant in various manifestations of coronary heart disease, including acute myocardial infarction

chronic circulatory failure

cardiac arrhythmias (arrhythmias caused by overdose of cardiac glycoside).

Contraindications

Hypersensitivity to Asparkam,

hyperkalemia,

hypermagnesemia,

acute and chronic renal failure,activity and safety not established).

Specific guidelines

No studies have been conducted to evaluate the effect of the drug on the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Composition

1 tablet contains:

active substances:

magnesium asparaginate 175 mg,

potassium asparaginate 175 mg

Dosage and administration

Inside, usually for adults, 1-2 tablets 3 times a day after meals.

The course of treatment is 3-4 weeks.

If necessary, you can repeat it.

Side effects

Possible nausea, dizziness,

redness of the face,

thirst,

lowering blood pressure, hyporeflexia.

hyperkalemia (nausea, vomiting, diarrhea, paresthesia) and hypermagnesemia (facial skin hyperemia, thirst, bradycardia, lowering blood pressure, muscle weakness, fatigue, paresis, coma, respiratory depression, cramps)

Drug interaction

Potassium-sparing diuretics (triamteren, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs - the risk of developing hyperkalemia and asolitis.

Eliminates hypokalemia caused by glucocorticosteroids.

Reduces unwanted effects of cardiac glycosides.

Due to the content of magnesium ions it reduces the effect of neomycin, polymyxin B, tetracycline and streptomycin.

Anesthetics enhance the inhibitory effect of magnesium on the central nervous system.

May enhance neuromuscular blockade caused by depolarizing muscle relaxants (atracuria besylate, decametonium bromide, suxamethonium (chloride, bromide, iodide)).

Calcitriol increases the concentration of magnesium in blood plasma, calcium preparations - reduce the effect of magnesium.

Storage conditions

At a temperature of 0 to 25 РC.

Deystvuyuschee substances

potassium and magnesium asparahynat

Terms and conditions

without prescription

dosage form

tablets

Prescribing

Nursing prescribing yu Vrach Dlya vzrosl h in naznacheniyu wizard, Beremenn m in naznacheniyu Vracha

Indications

Prevention of acute myocardial infarction, Serdechnaya failure, Violations rhythm of the heart, arrhythmia, Acute ynfarkt myocardium, Yshemycheskaya disease heart

PFC update, Russia