Piracetam solution 200mg / ml, 5ml No. 10

• Memory impairment, dizziness, decreased concentration, emotional lability, dementia due to cerebrovascular accident (ischemic stroke), brain injury,

• with Alzheimer's disease, in old age;

• coma of vascular, traumatic or toxic genesis;

• treatment of abstinence and psychoorganic syndrome in chronic alcoholism;

• learning disabilities in children, not associated with inadequate learning or the peculiarities of the family environment (as part of combination therapy);

• sickle cell anemia (as part of combination therapy).

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

For adults inside - 30-160 mg / kg / day in 2-4 doses. The duration of treatment is 6-8 weeks.

If necessary, apply intramuscularly or intravenously at an initial dose of 10 g / day. When administered intravenously to patients in serious condition, the daily dose may be 12 g. After clinical improvement, the dose is gradually reduced and switched to oral administration.

Children inside - 30-50 mg / kg / day in 2-3 doses. Treatment should be continued for at least 3 weeks.

The solution for intravenous and intramuscular administration is transparent, colorless or slightly colored.

1 ml piracetam 200 mg

Excipients : sodium acetate trihydrate - 1 mg, diluted acetic acid 30% - up to pH 5.0-7.0, water d / i - up to 1 ml.

5 ml - ampoules (5) - cardboard packs.
5 ml - ampoules (10) - cardboard packs.
10 ml - ampoules (5) - cardboard packs.
10 ml - ampoules (10) - cardboard packs.

Hemorrhagic stroke, severe renal failure (with CC <20 ml / min), hypersensitivity to piracetam.

Release form, packaging and composition of the drug Piracetam

The solution for intravenous and intramuscular administration is transparent, colorless or slightly colored.

1 ml piracetam 200 mg

Excipients : sodium acetate trihydrate - 1 mg, diluted acetic acid 30% - up to pH 5.0-7.0, water d / i - up to 1 ml.

5 ml - ampoules (5) - cardboard packs.
5 ml - ampoules (10) - cardboard packs.
10 ml - ampoules (5) - cardboard packs.
10 ml - ampoules (10) - cardboard packs.

Clinical and pharmacological group: Nootropic drug

Pharmaco-therapeutic group: Nootropic agent

pharmachologic effect

Nootropic agent. It has a positive effect on metabolic processes and blood circulation in the brain. Increases glucose utilization, improves metabolic processes, improves microcirculation in ischemic zones, inhibits the aggregation of activated platelets. It has a protective effect against brain damage caused by hypoxia, intoxication, and electroshock. Improves integrative brain activity. It does not have a sedative and psychostimulating effect.

Pharmacokinetics

When taken orally, it is rapidly and almost completely absorbed from the gastrointestinal tract. Cmax in plasma is reached after about 30 minutes, in cerebrospinal fluid - after 2-8 hours. Apparent Vd is 0.6 l / kg. Does not bind to blood plasma proteins.

It is distributed in all organs and tissues, penetrates the BBB and the placental barrier. Selectively accumulates in the tissues of the cerebral cortex, mainly in the frontal, parietal and occipital lobes, in the cerebellum and basal ganglia.

T1 / 2 from plasma is 4-5 hours, from cerebrospinal fluid - 6-8 hours. It is excreted by the kidneys unchanged. In renal failure, T1 / 2 increases.

Indications of the active substances of the drug Piracetam

Memory impairment, dizziness, decreased concentration, emotional lability, dementia due to cerebrovascular accident (ischemic stroke), brain trauma, Alzheimer's disease, in old age; coma of vascular, traumatic or toxic genesis; treatment of abstinence and psychoorganic syndrome in chronic alcoholism; learning disabilities in children, not associated with inadequate learning or the peculiarities of the family environment (as part of combination therapy); sickle cell anemia (as part of combination therapy).

Dosage regimen

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

For adults inside - 30-160 mg / kg / day in 2-4 doses. The duration of treatment is 6-8 weeks.

If necessary, apply intramuscularly or intravenously at an initial dose of 10 g / day. When administered intravenously to patients in serious condition, the daily dose may be 12 g. After clinical improvement, the dose is gradually reduced and switched to oral administration.

Children inside - 30-50 mg / kg / day in 2-3 doses. Treatment should be continued for at least 3 weeks.

Side effect

From the digestive system: rarely - dyspeptic symptoms, abdominal pain.

From the side of the central nervous system: rarely - nervousness, agitation, irritability, anxiety, sleep disorders, dizziness, headache, tremor; in some cases - weakness, drowsiness.

Others: increased sexual activity.

Contraindications for use

Hemorrhagic stroke, severe renal failure (with CC <20 ml / min), hypersensitivity to piracetam.

Application during pregnancy and lactation

There have been no adequate and well-controlled studies on the safety of piracetam during pregnancy. Application is possible only in cases where the intended benefit to the mother outweighs the possible risk to the fetus.

Piracetam appears to pass into breast milk. If necessary, use during lactation should decide on the termination of breastfeeding.

In experimental studies on animals, there was no negative effect of piracetam on the fetus.

Application for impaired renal function

Contraindicated in severe renal failure (with CC <20 ml / min).

Use with caution in patients with renal insufficiency. Continuous monitoring of indicators of renal function is recommended.

special instructions

Use with caution in patients with severe hemostasis disorder, major surgical operations and severe bleeding; with renal failure.

Continuous monitoring of indicators of renal function is recommended.

In case of sleep disturbances, it is recommended to cancel the evening intake of piracetam, adding this dose to the daily intake.

Drug interactions

A case of interaction of piracetam with simultaneous use with an extract of a thyroid gland containing triiodothyronine and tetraiodothyronine is described, when anxiety, irritability and sleep disorders were noted in the patient.

With simultaneous use with thyroid hormone preparations, the development of central effects is possible - tremor, anxiety, irritability, sleep disturbances, confusion.

With the simultaneous use of stimulants of the central nervous system, it is possible to enhance the psychostimulating effect.

With simultaneous use with antipsychotics, an increase in extrapyramidal disorders is observed.