Pimafucort cream, 15 g

Dermatoses amenable to glucocorticosteroid therapy, complicated by a secondary bacterial and / or fungal infection (especially caused by fungi of the genus Candida).

For adults and children, the drug is applied to the affected skin 2-4 times a day. The duration of treatment is determined individually, taking into account the nature of the disease, the course of treatment usually does not exceed 14 days.
In children, the drug should be applied to limited areas of the skin, do not use occlusive dressings. If there is no improvement in the condition in children and adults after 14 days, you should consult a doctor.
In the form of a cream, the drug is recommended for the treatment of acute and subacute dermatoses, incl. accompanied by oozing. The ointment is intended for the treatment of subacute and chronic dermatoses, especially in the presence of severe dry skin, lichenification, seborrhea, or in cases where the occlusive properties of the ointment are required.

1 g of cream contains:
Active substances:
Natamycin 10 mg
neomycin (in the form of neomycin sulfate) 3500 IU
micronized hydrocortisone 10 mg
Excipients:
Sodium citrate 14.0 mg, emulsifier F 115.0 mg, sorbitan stearate 30.0 mg, cetyl ether wax 60.0 mg, cetiol V 150.0, macrogol stearate 100 20.0 mg, methyl parahydroxybenzoate 2.0 mg, propyl parahydroxybenzoate 0.50 mg, purified water to 1000.0 mg.

- hypersensitivity to the components of the drug;
- tuberculosis of the skin, skin manifestations of syphilis, viral skin infections, skin post-vaccination reactions, open wounds, ulcers;
- acne, rosacea, ichthyosis;
- anogenital itching, skin tumors.

With caution
Use with caution in tuberculosis (systemic damage)
- in children under the age of 1 year;
- in patients with a history of indications of the defeat of the IX pair of craniocerebral neoplasms against the background of the use of aminoglycosides.

In the presence of perforation of the tympanic membrane and direct exposure of the middle ear to neomycin, there is a risk of ototoxicity.

Trade name: PimafukortЃ

Dosage form:
- cream for external use
- ointment for external use

Description:
Cream: cream from white to white with a yellowish sheen.
Ointment: White to yellow ointment.

Composition:
Cream:
1 g of cream contains:
Active substances:
Natamycin 10 mg
neomycin (in the form of neomycin sulfate) 3500 IU
micronized hydrocortisone 10 mg
Excipients:
Sodium citrate 14.0 mg, emulsifier F 115.0 mg, sorbitan stearate 30.0 mg, cetyl ether wax 60.0 mg, cetiol V 150.0, macrogol stearate 100 20.0 mg, methyl parahydroxybenzoate 2.0 mg, propyl parahydroxybenzoate 0.50 mg, purified water to 1000.0 mg.

Ointment:
1 g of ointment contains:
Active substances:
Natamycin 10 mg
neomycin (in the form of neomycin sulfate) 3500 IU
micronized hydrocortisone 10 mg
Excipients:
Polyethylene ointment base (95% liquid paraffin, 5% polyethylene) 976.5 mg.

Pharmacotherapeutic group:
glucocorticoids + antibiotic aminoglycoside + antifungal agent

Pharmacological action
Combined drug with antibacterial, antifungal, local anti-inflammatory effect.
Neomycin is a broad-spectrum antibiotic from the aminoglycoside group, active against a number of gram-positive (Staphylococcus spp., Enterococcus spp.) And gram-negative (Klebsiella spp., Proteus spp., Escherichiacoli , etc.) bacteria.

Natamycin refers to antifungal drugs of the polyene series, has a fungicidal effect against yeast and yeast-like fungi, especially Candida spp. Dermatomycetes are less sensitive to natamycin.
Hydrocortisone has anti-inflammatory and vasoconstrictor effects.
Eliminates inflammation and itching that accompany various types of dermatoses.

Pharmacokinetics
Natamycin and neomycin are practically not absorbed through intact skin and mucous membranes. Absorption of neomycin through damaged skin is possible, if the drug gets on wounds, ulcers. Through intact skin, 1 to 3% of hydrocortisone is absorbed; with dermatitis, the amount of absorbed hydrocortisone doubles, with infectious skin lesions, it can increase up to 5 times. In children, the absorption of hydrocortisone through intact skin is higher than in adults, the degree of absorption of the drug into the systemic circulation decreases with age.

Indications for use
Dermatoses, amenable to glucocorticosteroid therapy, complicated by secondary bacterial and / or fungal infection (especially caused by fungi of the genus Candida).

Contraindications
- hypersensitivity to the components of the drug;
- tuberculosis of the skin, skin manifestations of syphilis, viral skin infections, skin post-vaccination reactions, open wounds, ulcers;
- acne, rosacea, ichthyosis;
- anogenital itching, skin tumors.

With caution
Use with caution in tuberculosis (systemic damage)
- in children under the age of 1 year;
- in patients with a history of indications of the defeat of the IX pair of craniocerebral neoplasms against the background of the use of aminoglycosides.

In the presence of perforation of the tympanic membrane and direct exposure of the middle ear to neomycin, there is a risk of ototoxicity.

Pregnancy and lactation
When prescribing the drug during pregnancy, it is necessary to take into account the theoretical risk of the ototoxic effect of neomycin, and therefore it is impossible to use the drug for a long time and apply it under occlusive dressings.

Dosage and administration For
adults and children, the drug is applied to the affected skin 2-4 times a day. The duration of treatment is determined individually, taking into account the nature of the disease, the course of treatment usually does not exceed 14 days.
In children, the drug should be applied to limited areas of the skin, do not use occlusive dressings. If there is no improvement in the condition in children and adults after 14 days, you should consult a doctor.
In the form of a cream, the drug is recommended for the treatment of acute and subacute dermatoses, incl. accompanied by oozing. The ointment is intended for the treatment of subacute and chronic dermatoses, especially in the presence of severe dry skin, lichenification, seborrhea, or in cases where the occlusive properties of the ointment are required.

Side effects
Side effects with external use of Pimafucort, as with the use of other glucocorticosteroids, are rare and reversible. Rarely, a hypersensitivity reaction (itching, burning, redness, or dryness of the skin) may develop.
Extremely rare - atrophy and thinning of the skin, telangiectasia, striae, purpura, rosacea-like and perioral dermatitis, delayed wound healing, depigmentation, hypertrichosis, withdrawal syndrome after stopping treatment.
When using external glucocorticosteroids for a long time, on large areas of the skin, or when using occlusive dressings, especially in children, side effects characteristic of systemic glucocorticosteroids, such as suppression of the function of the adrenal cortex, may develop.
Contact dermatitis to neomycin.

Overdose
There is no data on drug overdose. There is a theoretical possibility of the ototoxic effect of neomycin in the case of application of the drug to the area of ??the external auditory canal in the presence of perforation of the tympanic membrane and the direct effect of neomycin on the middle ear.

Drug Interactions
Drug interactions have not been described.
There may be cross-hypersensitivity between neomycin and drugs of similar chemical structure, such as kanamycin, paromomycin, gentamicin, and cross-resistance between neomycin and other antibiotics of the aminoglycoside group.

Special instructions
When applying Pimafucort to the eyelids and periorbital area, there is a risk of increased intraocular pressure and the development of cataracts.
When using the drug on large surfaces in children or under bandages, it is necessary to keep in mind the possibility of suppressing the function of the hypothalamic-pituitary-adrenal system.
In the case of prolonged treatment, in the presence of wounds and ulcers, there is a theoretical risk of ototoxic and nephrotoxic effects of neomycin.
If superinfection or overgrowth of fungi occurs, the drug should be discontinued and appropriate measures should be taken.

Release form
Ointment and cream for external use:
15 g each in aluminum or plastic tubes, treated with epoxy varnish, closed with an aluminum membrane and a screw-on polyethylene cap with a device for piercing the membrane.
1 tube with instructions for use in a cardboard box.

Terms and conditions of storage
At a temperature not exceeding 25 ? —. Keep out of the reach of children.

The shelf life of the
cream is 3 years, the ointment is 5 years.
Do not use after the expiration date.

Terms of dispensing from pharmacies
Without a doctor's prescription.