Pimafucin vaginal suppositories 100mg, No. 3

Fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug, including:

• acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;

• otomycosis, otitis externa, either primarily caused by fungi, or complicated by candidiasis;

• candidiasis of the skin and nails;

• intestinal candidiasis;

• vaginitis, vulvitis, vulvovaginitis, balanoposthitis, caused mainly by Candida fungi ;

• dermatomycosis.

For vaginitis, vulvitis, vulvovaginitis , 1 vaginal suppository is prescribed for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, 1 time / day. at night. With a persistent course of vaginitis caused by Candida albicans, tablets are additionally prescribed inside (1 tab. 4 times / day for 10-20 days) to sanitize the focus of candidal infection in the intestine. For the treatment of candidal lesions of the partner's genitals, PimafucinЃ is used in the form of a cream.

Vaginal suppositories.

1 suppository contains: natamycin 100 mg.

Hypersensitivity to the components of the drug.

Dosage form:

Vaginal suppositories

Composition:

Vaginal suppositories.

1 suppository contains: natamycin 100 mg.

Description:
Vaginal suppositories: torpedo-shaped, color from white to pale yellow;
Enteric-coated tablets: White round film-coated tablets.
Cream: homogeneous cream of light shade.

Pharmacological properties

Pharmacotherapeutic group.

Antimicrobial, antiparasitic and antihelminthic agents, insecticides, including repellents, antifungal agents.

Pharmacodynamics.

Antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms. Most pathogenic yeasts, especially Candida albicans , are sensitive to natamycin . Dermatophytes are less sensitive to natamycin. Resistance to natamycin does not occur in clinical practice. Natamycin in tablets, due to the enteric coating, acts only in the intestine.
Pharmacokinetics.

Natamycin is not absorbed from the gastrointestinal tract, through intact skin and mucous membranes.

Indications for use
Fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug, including:

• acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;

• otomycosis, otitis externa, either primarily caused by fungi, or complicated by candidiasis;

• candidiasis of the skin and nails;

• intestinal candidiasis;

• vaginitis, vulvitis, vulvovaginitis, balanoposthitis, caused mainly by Candida fungi ;

• dermatomycosis.

Contraindications
Hypersensitivity to the components of the drug.

Method of administration and dosage.
For vaginitis, vulvitis, vulvovaginitis , 1 vaginal suppository is prescribed for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, 1 time / day. at night. With a persistent course of vaginitis caused by Candida albicans, tablets are additionally prescribed inside (1 tab. 4 times / day for 10-20 days) to sanitize the focus of candidal infection in the intestine. For the treatment of candidal lesions of the partner's genitals, PimafucinЃ is used in the form of a cream.

Interaction with other drugs
Drug interaction of the drug Pimafucin is not described.

Special instructions.

Vaginal suppositories under the influence of body temperature quickly dissolve, forming a foamy mass, which contributes to the uniform distribution of the active substance. In the case of a chronic or recurrent infection, topical treatment can be supplemented with pills and a cream. Ethanol, which is part of vaginal suppositories, can cause hypersensitivity reactions. During menstruation, suppository therapy is interrupted. During the period of treatment with suppositories, there is no need to exclude sexual intercourse. However, it is recommended to conduct an examination of the sexual partners and, if a candidal lesion is detected, to conduct a course of treatment with Pimafucin. You should also provide for the use of barrier contraceptives during the treatment period.

PimafucinЃ can be administered to newborns.

Pregnancy and lactation. It is possible to use Pimafucin during pregnancy and lactation.

Side effect.
Local reactions: possible slight irritation, burning sensation (when applying cream, vaginal suppositories).

Overdose of the drug.

Currently, no cases of overdose of PimafucinЃ have been reported.

Storage conditions.

The drug should be stored at a temperature of 15 to 25 ? C out of the reach of children.

Shelf life.

Shelf life of vaginal suppositories is 2 years. Do not use after the expiration date.