Pimafucin tablets p / o 100mg, No. 20

Fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug, including:

• acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;

• otomycosis, otitis externa, either primarily caused by fungi, or complicated by candidiasis;

• candidiasis of the skin and nails;

• intestinal candidiasis;

• vaginitis, vulvitis, vulvovaginitis, balanoposthitis, caused mainly by Candida fungi ;

• dermatomycosis.

With intestinal candidiasis, adults are prescribed 1 tab. 4 times / day on average within 1 week. Children are prescribed 1 tab. 2 times / day
For dermatomycosis (including candidiasis of the skin and nails, diaper rash in children), the cream is applied to the affected surface of the skin and nails 1 or several times a day.
With otomycosis, the affected surface is lubricated with cream 1 or several times a day. Before using the drug, the ear is cleaned. After applying the drug, a turunda made of natural material (cotton, wool) is placed in the ear canal.

For vaginitis, vulvitis, vulvovaginitis , 1 vaginal suppository is prescribed for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, 1 time / day. at night. With a persistent course of vaginitis caused by Candida albicans, tablets are additionally prescribed inside (1 tab. 4 times / day for 10-20 days) to sanitize the focus of candidal infection in the intestine. For the treatment of candidal lesions of the partner's genitals, PimafucinЃ is used in the form of a cream.

With balanoposthitis, the cream is applied to the affected areas of the skin one or more times a day. The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several more days.

1 tablet contains: natamycin 100 mg.

Hypersensitivity to the components of the drug.

Dosage form:

Enteric-coated tablets;

Composition:

1 tablet contains: natamycin 100 mg.

Description:
Enteric-coated tablets: white round film-coated tablets.

Pharmacological properties

Pharmacotherapeutic group.

Antimicrobial, antiparasitic and antihelminthic agents, insecticides, including repellents, antifungal agents.

Pharmacodynamics.

Antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms. Most pathogenic yeasts, especially Candida albicans , are sensitive to natamycin . Dermatophytes are less sensitive to natamycin. Resistance to natamycin does not occur in clinical practice. Natamycin in tablets, due to the enteric coating, acts only in the intestine.
Pharmacokinetics.

Natamycin is not absorbed from the gastrointestinal tract, through intact skin and mucous membranes.

Indications for use
Fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug, including:

• acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;

• otomycosis, otitis externa, either primarily caused by fungi, or complicated by candidiasis;

• candidiasis of the skin and nails;

• intestinal candidiasis;

• vaginitis, vulvitis, vulvovaginitis, balanoposthitis, caused mainly by Candida fungi ;

• dermatomycosis.

Contraindications
Hypersensitivity to the components of the drug.

Method of administration and dosage.
With intestinal candidiasis, adults are prescribed 1 tab. 4 times / day on average within 1 week. Children are prescribed 1 tab. 2 times / day

Interaction with other drugs
Drug interaction of the drug Pimafucin is not described.

PimafucinЃ can be administered to newborns.

Pregnancy and lactation.

It is possible to use Pimafucin during pregnancy and lactation.

Side effect.
From the gastrointestinal tract: nausea and diarrhea are possible (occurring in the first days of taking the pills and passing on their own during treatment). Local reactions: possible slight irritation, burning sensation (when applying cream, vaginal suppositories).

Overdose of the drug.

Currently, no cases of overdose of PimafucinЃ have been reported.

Storage conditions.

The drug should be stored at a temperature of 15 to 25 ? C out of the reach of children.

Shelf life is 4 years.

Do not use after the expiration date.