Picamilon solution for oral administration 20mg / 5ml, 100ml

• Cerebrovascular insufficiency, asthenia, depressive disorders in old age.

• Conditions accompanied by anxiety, fear, increased irritability, emotional lability.

• Asthenic conditions due to various neuropsychiatric diseases.

• As part of complex treatment - for relief of acute alcohol intoxication; in chronic alcoholism - to reduce asthenic, asthenoneurotic, postpsychotic, pre-relapse states, as well as alcoholic encephalopathy.

• As part of complex therapy - migraine (prevention), TBI, neuroinfection.

• Improving the tolerance of physical and mental stress (for persons who are in stressful and extreme conditions of activity; to restore the physical performance of athletes, to increase resistance to physical and mental stress).

• Open-angle glaucoma (to stabilize visual function).

• In urological practice (in children over 3 years old and in adults with urination disorders) to improve the adaptive function of the bladder (decrease detrusor hypoxia).

It is taken orally, regardless of the meal. For cerebrovascular diseases, a single dose is 20-50 mg 2-3 times / day, a daily dose is 60-150 mg. The course of treatment is 1-2 months. A second course - in 5-6 months.

Depressive states of late age: 40-200 mg / day for 2-3 doses, the optimal dose range is 60-120 mg / day for 1.5-3 months.

As an antiasthenic and anxiolytic agent - 40-80 mg / day, if necessary - up to 200-300 mg / day, for 1-1.5 months.

With alcoholism during the period of abstinence, it is prescribed at a dose of 100-150 mg / day, in a short course of 6-7 days; for more persistent disorders outside abstinence - 40-60 mg / day for 4-5 weeks.

To restore working capacity and with increased loads - 60-80 mg / day for 1-1.5 months, for athletes in the same dose for 2 weeks. training period.

Parenterally administered intravenously drip or jet (slowly), intramuscularly.

For chronic disorders of cerebral circulation - i / v or i / m, 100-200 mg, 1-2 times / day, daily dose - 20-40 mg. Depending on the patient's condition, it is used in the morning intravenous drip, in the evening - intramuscularly; or within 10 days i / v, then i / m. The course of treatment is 15-30 days.

For relief of acute uncomplicated intoxication with ethanol as part of complex therapy, it is administered in a saturating dose of 5 mg / kg and a maintenance dose of 1.56 mg / kg / h in a volume of 2.5 l of infusion solution, for 4 hours, in the morning and in the evening. In asthenic conditions, depending on the severity of the disease, in addition to oral administration, intramuscular injection is administered in a daily dose of 20-40 mg for 1 month

Oral solution in the form of a colorless, odorless, transparent liquid.

1 ml

N-nicotinoyl-gamma-aminobutyric acid sodium salt 4 mg

Excipients: sodium citrate - 10.59 mg, methyl parahydroxybenzoate - 1.8 mg, strawberry flavor - 1 mg, sucralose - 0.47 mg, propyl parahydroxybenzoate - 0.2 mg, citric acid monohydrate - 0.05 mg, purified water - up to 1 ml.

• Chronic renal failure

• pregnancy,

• lactation period,

• hypersensitivity to nicotinoyl gamma-aminobutyric acid.

Pharmacological properties:

Pharmacodynamics:

Nootropic agent, dilates the blood vessels of the brain. It has a tranquilizing and mild psychostimulating effect, antiplatelet and antioxidant effect. Improves the functional state of the brain due to the normalization of tissue metabolism and influence on cerebral circulation (increases the volumetric and linear velocity of cerebral blood flow, has a vasodilating, antiplatelet, antioxidant effect, improves microcirculation). With a course admission, it increases physical and mental performance, reduces headache, improves memory, normalizes sleep; helps to reduce or disappear feelings of anxiety, tension, fear, emotional incontinence. Promotes the restoration of central motor and speech disorders of vascular or traumatic genesis.Improves blood circulation in the vessels of the retina and optic nerve.

Pharmacokinetics:

Absorption is fast and complete with any route of administration. Penetrates through the blood-brain barrier, is retained for a long time in the tissues of the body. Bioavailability is 50-88%. It is excreted mainly by the kidneys unchanged. The half-life is 0.51 hours.

Side effect

From the side of the central nervous system: irritability, agitation, anxiety, dizziness, headache. Allergic reactions: skin rash, itching. Others: nausea.

Application during pregnancy and lactation

Contraindicated for use during pregnancy, lactation (breastfeeding).

Application for impaired renal function

Contraindicated in chronic renal failure.

Drug interactions

Reduces the duration of action of barbiturates. Enhances the action of narcotic analgesics.