Phlebodia 600 tab. p / o captivity. 600mg # 15

Release form, composition and packaging

Pink film-coated tablets, round, biconvex.

1 tab.

diosmin on a dry matter basis 600 mg

talc - 10.24 mg, colloidal silicon dioxide - 3.5 mg, stearic acid - 50.05 mg, microcrystalline cellulose - up to 910 mg.

The composition of the film shell: Sepifilm002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg)

Sepispers AP 5523 pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, iron oxide black (E 172) - 0.13 mg, iron oxide red (E 172) - 0.02 mg)

Opaglos6000 (carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.15 mg, ethanol 95 g. - traces).

15 pcs.

- PVC / aluminum blisters (1) - cardboard packs.

15 pcs.

- PVC / aluminum blisters (2) - cardboard packs.

15 pcs.

- PVC / aluminum blisters (3) - cardboard packs.

pharmachologic effect

The drug has a phlebotonizing effect (reduces the elasticity of veins, increases the tone of the veins (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, has an anti-inflammatory effect.

Strengthens the vasoconstrictor effect of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

It is rapidly absorbed from the gastrointestinal tract, is found in plasma 2 hours after ingestion.

Cmax in blood plasma is reached 5 hours after administration.

It is evenly distributed and accumulates in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent in the kidneys, liver and lungs and other tissues.

Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum by 9 hours after administration and lasts for 96 hours. Excreted by the kidneys - 79%, intestines - 11%, with bile - 2.4%.

Indications for use

As part of complex therapy:

- to eliminate the symptoms of lymphovenous insufficiency of the lower extremities: a feeling of heaviness or fatigue in the legs, pain

- additional treatment for microcirculation disorders

- symptomatic therapy of acute hemorrhoids.

Contraindications for use

- hypersensitivity to drug components

- the period of breastfeeding

- children up to age 18

- pregnancy (I trimester) (experience of use is limited).

Dosage regimen

Before using the drug, you should consult your doctor.

The drug is intended for oral administration.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), 1 tablet is prescribed / day.

in the morning on an empty stomach.

The duration of therapy is usually 2 months.

With an exacerbation of hemorrhoids, the drug is prescribed for 2-3 tablets / day.

with meals for 7 days.

If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.

Overdose

Overdose symptoms are not described.

Side effect

In rare cases, hypersensitivity to the components of the drug, requiring a break in treatment: from the gastrointestinal tract - dyspeptic disorders (heartburn, nausea, abdominal pain), from the central nervous system - headache.

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions

Name ENG

PHLEBODIA 600

Clinical and pharmacological group

Venotonic drug

ATX code

Diosmin

Dosage

600mg

Structure

1 film-coated tablet contains: active ingredient: diosmin (calculated on dry matter) 600 mg.

excipients: talc - 10.24 mg

colloidal silicon dioxide - 3.5 mg

stearic acid - 50.05 mg

MCC - up to 910 mg.

film shell: Sepifilm 002 (hypromellose (E464) - 9.832 mg, MCC - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg)

Sepispers AR 5523 pink (propylene glycol - traces, hypromellose (E464) - 0.458 mg, titanium dioxide (E171) - 4.026 mg, crimson dye [Ponso 4R] (E124) - 0.401 mg, black iron oxide (E172) - 0.13 mg , iron oxide red (E172) - 0.02 mg)

Opaglos 6000 (carnauba wax (E903) - 0.075 mg, beeswax (E901) - 0.075 mg, shellac (E904) - 0.15 mg, ethanol 95 ° - traces),

Indications

As part of complex therapy:

elimination of symptoms of lymphovenous insufficiency of the lower extremities: a feeling of heaviness or fatigue in the legs, pain

additional treatment for microcirculation disorders

acute hemorrhoids (symptomatic therapy).

Storage conditions and periods

At a temperature not higher than 30 degrees.

Expiration date: 3 years

Contraindications

hypersensitivity to the components of the drug Phlebodia 600

period of breastfeeding

pregnancy (I trimester of use is limited)

children's age (under 18 years old).

INN / Active ingredient

Diosmin

Specifications

Scope of the drug

Heart, vessels, blood

Release form

Tablet

Manufacturer country

France

Package quantity, pcs

15

Minimum age from

18 years

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Innothera

The amount of the dosage form in the primary package

15 pcs.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Angioprotective agent

Anatomical and therapeutic characteristics

C05CA03 Diosmin

Dosage form

Film-coated tablets

Expiration date in days

1095

Dosage (volume) of the substance in the preparation

diosmin - 600 mg

Package weight, g

25

Category

:

Improving blood circulation

,

Angioprotectors and microcirculation correctors

,

Lipid-lowering drugs

,

Hematopoietic stimulants

Mode of application

:

Before using the drug, you should consult a doctor. < br> The drug is intended for oral administration. < br> With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), 1 tablet is prescribed per day in the morning on an empty stomach.

The duration of therapy is usually 2 months.

With an exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets per day with meals for 7 days.

If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.

Information on technical characteristics, delivery set, country of manufacture